Volume 29, Issue 12 (March 2019)
Studies in Medical Sciences 2019, 29(12): 913-919 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
mosallanezhad Z, hemmatinafar M, sotoodeh A, erfanian S. The Effect of High-Intensity Interval Training on telomere length, telomerase, and telomere related factors of Leukocytes in Sedentary Young Women. Studies in Medical Sciences 2019; 29 (12) :913-919
URL: http://umj.umsu.ac.ir/article-1-4552-en.html
URL: http://umj.umsu.ac.ir/article-1-4552-en.html
1. Arsenis NC, You T, Ogawa EF, Tinsley GM, Zuo L. Physical activity and telomere length: Impact of aging and potential mechanisms of action. Oncotarget 2017;8(27):45008–19. 2. Laye MJ, Solomon TPJ, Karstoft K, Pedersen KK, Nielsen SD, Pedersen BK.Increased shelterin mRNA expression in peripheral blood mononuclear cells and skeletal muscle Following an ultra-long-distance running event. J Apple Physiol. 2012; 112(5):773-81. 3. Ludlow AT, Roth SM. Physical activity and telomere biology: exploring the link with aging-related disease prevention. J Aging Res 2011;790378. 4. Werner C, Furster T, Widmann T, Poss J, Roggia C, Hanhoun M, et al. Physical exercise prevents cellular senescence in circulating leukocytes and in the vessel wall. Circulation 2009; 120: 2438-47. 5. Choi ES, Chang YK, Lee DH, Ko J-H, Lim I, Bang H, et al. Gender-specific associations between quality of life and leukocyte telomere length. Maturitas 2018;107:68–70. 6. Hemmatinafar M, Kordi M, Choopani S, Choobineh S, Gharari Arefi R. The Effect of High Intensity Interval Training (HIIT) on Plasma Adiponectin Levels, Insulin Sensitivity and Resistance in Sedentary Young Men. ZUMS 2013; 21 (84):1-12. 7. Smith M.J. Sprint Interval Training - “It’s a HIIT!”. 1st Ed. 2008. 8. Noori Mofrad SR, Ebrahim Kh. The effect of high intensity interval training on telomere length and telomerase activity in non-athlete young men. J Bas Res Med Sci 2018; 5(2):1-7. 9. Glaister M, Hauck H, Abraham CS, Merry KL, Beaver D, Woods B. Familiarization, reliability, and comparability of a 40-m maximal shuttle run test. J Spor ts Sci 2009; 8: 77-82. 10. Holt SE, Norton JC, Wright WE, Shay JW. Comparison of the telomeric repeat amplification protocol (TRAP) to the new TRAP-eze telomerase detection kit. Methods Cell Sci 1996; 18:237-48. 11. Silva LCR, de Araújo AL, Fernandes JR, Matias M de ST, Silva PR, Duarte AJS, et al. Moderate and intense exercise lifestyles attenuate the effects of aging on telomere length and the survival and composition of T cell subpopulations. Age (Dordr) 2016;38(1):24. 12. Tucker L.A. Physical activity and telomere length in U.S. Men and women: An NHANES investigation. Prev Med 2017, 100, 145–51. 13. Rehkopf DH, Needham BL, Lin J, Blackburn EH, Zota AR, Wojcicki JM, et al. Leukocyte Telomere Length in Relation to 17 Biomarkers of Cardiovascular Disease Risk:A Cross-Sectional Study of US Adults. PLoS Med 2016; 13: e1002188. 14. Denham J, Nelson CP, O’Brien BJ, Nankervis SA, Denniff M, Harvey JT, et al. Longer leukocyte telomeres are associated with ultra-endurance exercise independent of cardiovascular risk Factors. PLoS One 2013; 8: e69377. 15. Zietzer A, Buschmann E.E, Janke D, Li L, Brix M, Meyborg H, et al. Acute physical exercise and long-term individual shear rate therapy increase telomerase activity in human peripheral blood mononuclear cells. Acta Phys. 2016, 220, 251–62. 16. Ludlow AT, Zimmerman JB, Witkowski S, Hearn JW, Hatfield BD, Roth SM. Relationship between physical activity level, telomere length, and telomerase activity. Med Sci Sports Exerc 2008; 40: 1764-71. 17. Buchan DS, Ollis S, Young JD, Thomas NE, Cooper S-M, Tong TK, et al. The effects of time and intensity of exercise on novel and established markers of CVD in adolescent youth. Am J Hum Biol 2011;23(4):517–26. 18. Ludlow AT, Roth SM. Physical activity and telomere biology: exploring the link with aging-related disease prevention. J Aging Res 2011;2011:790378. 19. Laye MJ, Solomon TPJ, Karstoft K, Pedersen KK, Nielsen SD, Pedersen BK. Increased shelterin mRNA expression in peripheral blood mononuclear cells and skeletal muscle following an ultra-long-distance running event. J Appl Physiol 2012; 112(5):773-81. 20. Andrew T, Witkowski S, Mallory R. Jenny Wang M, Laila CJ. Lisa M. et al. Chronic Exercise Modifi es Age-Related Telomere Dynamics in a Tissue-Specifi c Fashion. J Gerontol A Biol Sci Med Sci 2012;67(9):911–26. 21. Werner C, Hauser M, Meyer T, Boehm M, Laufs U. High-intensity interval training reduces P53 expression and increases telomerase activity in circulating mononuclear cells of untrained subjects. Circulation 2012;126:A18220. 22. Shadyab AH, LaMonte MJ, Kooperberg C, Reiner AP, Carty CL, Manini TM, et al. Leisure-time physical activity and leukocyte telomere length among older women. Exp Gerontol 2017;95:141–7. 23. Denham J. Lack of association between pbmc telomere length and endurance exercise. J Appl Biomed 2016;15: 9-13. 24. Laine MK, Eriksson JG, Kujala UM, Raj R, Kaprio J, Bäckmand HM, et al. Effect of intensive exercise in early adult life on telomere length in later life in men. J Sports Sci Med 2015;14(2):239–45. 25. Von Känel R, Bruwer EJ, Hamer M, de Ridder JH, Malan L. Association between objectively measured physical activity, chronic stress and leukocyte telomere length. J Sports Med Phys Fitness 2017;57(10):1349–58. 26. Puterman E, Weiss J, Lin J, Schilf S, Slusher AL, Johansen KL, et al. Aerobic exercise lengthens telomeres and reduces stress in family caregivers: A randomized controlled trial - Curt Richter Award Paper 2018. Psychoneuroendocrinology 2018;98:245–52. 27. Friedenreich CM, Wang Q, Ting NS, Brenner DR, Conroy SM, McIntyre JB, et al. Effect of a 12-month exercise intervention on leukocyte telomere length: Results from the ALPHA Trial. Cancer Epidemiol 2018;56:67–74. 28. Werner CM, Hecksteden A, Morsch A, Zundler J, Wegmann M, Kratzsch J, et al. Differential effects of endurance, interval, and resistance training on telomerase activity and telomere length in a randomized, controlled study. Eur Heart J 2019;40(1):34–46. , m.hemmatinafar@shirazu.ac.ir
Abstract: (3761 Views)
Background & Aims: The purpose of this study was to examine the effect of eight-week high-intensity interval training (HIIT) on telomere length and telomere factors of leukocytes in sedentary young women.
Materials & Methods: A total of 21 students voluntarily participated in this study. The participants were randomly divided into two groups: the experimental group (n=11, age=23.25±2.01 years, height=163.32±5.44 cm, and weight=62.2±7.56 kg) and the control group (n=10, age=24.42±1.32 years, height=165.00±4.88 cm, and weight=66.6±6.30 kg). The experimental group performed three sessions of HIIT a week for eight weeks. Every session included three-six runs with maximum speed in a 20-metre area with 30 seconds of rest between each run. The fasting blood samples were collected immediately before and after the exercise protocol. The telomere length was measured using Real Time PCR method. The data were analysed using independent and paired t-tests.
Results: The results showed that leukocyte telomere length (T/S ratio) (p=.04) and telomerase activity (p=.04) in the experimental group increased significantly. Moreover, the body fat percentage, BMI, and weight of the experimental group decreased significantly.
Conclusion: The results of this study showed that HIIT increases the leukocyte telomere length in sedentary young women, making it an efficient and appropriate method of exercise.
Materials & Methods: A total of 21 students voluntarily participated in this study. The participants were randomly divided into two groups: the experimental group (n=11, age=23.25±2.01 years, height=163.32±5.44 cm, and weight=62.2±7.56 kg) and the control group (n=10, age=24.42±1.32 years, height=165.00±4.88 cm, and weight=66.6±6.30 kg). The experimental group performed three sessions of HIIT a week for eight weeks. Every session included three-six runs with maximum speed in a 20-metre area with 30 seconds of rest between each run. The fasting blood samples were collected immediately before and after the exercise protocol. The telomere length was measured using Real Time PCR method. The data were analysed using independent and paired t-tests.
Results: The results showed that leukocyte telomere length (T/S ratio) (p=.04) and telomerase activity (p=.04) in the experimental group increased significantly. Moreover, the body fat percentage, BMI, and weight of the experimental group decreased significantly.
Conclusion: The results of this study showed that HIIT increases the leukocyte telomere length in sedentary young women, making it an efficient and appropriate method of exercise.
Type of Study: case report |
Subject:
Exercise physiology
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
