Volume 28, Issue 10 (Monthly_Jan 2018)
Studies in Medical Sciences 2018, 28(10): 589-600 |
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Karami Z, Hassanpour-Ezatti M. EFFECT OF ADMINISTRATION OF NANO-ZINC OXIDE ON THERMAL HYPERALGESIA INDUCED BY ACUTE AND CHRONIC TREATMENT OF PACLITAXEL IN MICE. Studies in Medical Sciences 2018; 28 (10) :589-600
URL: http://umj.umsu.ac.ir/article-1-3931-en.html
URL: http://umj.umsu.ac.ir/article-1-3931-en.html
Shahed University , tanhasetareyeshab@gmail.com
Abstract: (5149 Views)
Background & Aims: Multiple evidences available about zinc oxide nanoparticles (nano-ZnO) ameliorative effects on neuroinflammation that worked in contrast to mechanisms activate with paclitaxel. In this study, effect of local and intraperitoneal application of nano-ZnO on paclitaxel-induced acute and chronic thermal hyperalgesia in mice was evaluated.
Materials & Methods: Adult male mice (35-40 g) were divided into acute and chronic studies categories. Acute groups received paclitaxel (20 mg/kg, single dose, i.p.) and nano-ZnO (100 and 500 µg, intraplantar) with paclitaxel and Chronic groups received nano-ZnO (0.1, 1, 10, mg/kg, i.p.) and (4.5 mg/kg, i.p.) for 4 days. The control group received paclitaxel (4.5 mg/kg, i.p.) for 4 days. Paw withdrawal latency from hot (46ºC) and cold (2-3ºC) water was evaluated after each treatment.
Results: Paclitaxel caused hot and cold thermal hyperalgesia in chronic regimen but only induced hot thermal hyperalgesia in acute treatment regimen. In mice, treatment with nano-ZnO significantly and dose-dependently suppressed cold and hot hyperalgesia induced by chronic paclitaxel treatment and also reduced hot thermal hyperalgesia in acute paclitaxel treated.
Conclusion: The results indicate that nano-ZnO can reduce hot thermal neuropathic hyperalgesia induced by acute and chronic models of paclitaxel hyperalgesia. The efficacy of nano-ZnO treatment on acute and chronic models of paclitaxel-induced painful thermal hyperalgesia can provide useful evidence for further exploring in clinical researches on it.
Materials & Methods: Adult male mice (35-40 g) were divided into acute and chronic studies categories. Acute groups received paclitaxel (20 mg/kg, single dose, i.p.) and nano-ZnO (100 and 500 µg, intraplantar) with paclitaxel and Chronic groups received nano-ZnO (0.1, 1, 10, mg/kg, i.p.) and (4.5 mg/kg, i.p.) for 4 days. The control group received paclitaxel (4.5 mg/kg, i.p.) for 4 days. Paw withdrawal latency from hot (46ºC) and cold (2-3ºC) water was evaluated after each treatment.
Results: Paclitaxel caused hot and cold thermal hyperalgesia in chronic regimen but only induced hot thermal hyperalgesia in acute treatment regimen. In mice, treatment with nano-ZnO significantly and dose-dependently suppressed cold and hot hyperalgesia induced by chronic paclitaxel treatment and also reduced hot thermal hyperalgesia in acute paclitaxel treated.
Conclusion: The results indicate that nano-ZnO can reduce hot thermal neuropathic hyperalgesia induced by acute and chronic models of paclitaxel hyperalgesia. The efficacy of nano-ZnO treatment on acute and chronic models of paclitaxel-induced painful thermal hyperalgesia can provide useful evidence for further exploring in clinical researches on it.
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