Volume 34, Issue 12 (12-2023)
Studies in Medical Sciences 2023, 34(12): 826-834 |
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Moghaddam-manesh M, Shahraki R, Hosseinzadegan S, Shahraki Salar Z. INVESTIGATING ANTIBACTERIAL EFFECT OF NEW MAGNETIC NANOPARTICLE AND [1,3]-DITHIINE DERIVATIVES AGAINST LACTOCOCCUS GARVIEAE. Studies in Medical Sciences 2023; 34 (12) :826-834
URL: http://umj.umsu.ac.ir/article-1-5203-en.html
URL: http://umj.umsu.ac.ir/article-1-5203-en.html
PhD of Organic Chemistry, Petrochemical and Polymer Research Group, Chemical and Petrochemical Research Institute, Standard Research Institute, Karaj, Iran (Corresponding Author) , mrm.manesh@gmail.com
Abstract: (1592 Views)
Background & Aims: Loctococcus garvieae is a common bacterium between humans and animals, and it causes various diseases such as lactococcosis in aquatic animals. The [1,3]-Dithiine with two sulfur atoms in its structure is found in natural compounds such as garlic. Due to the antimicrobial activity of the [1,3]-Dithiine derivatives, and magnetic nanoparticles, in this study, antibacterial effects of the derivatives of this compound against Loctococcus garvieae were evaluated.
Materials & Methods: Six derivatives of [1,3]-Dithiine and a magnetic nanoparticles containing [1,3]-Dithiine were synthesized and antibacterial activity against Loctococcus garvieae were evaluated. Antimicrobial property was assessed using the CLSI (Clinical & Laboratory Standards Institut) standard and compared with gentamicin as a commercial drug.
Results: Synthetic derivatives of [1,3]-Dithiine and magnetic nanoparticles showed acceptable antibacterial effects based on IZD (inhibition zone diameter), MIC (minimum inhibitory concentration), and MBC (minimum bactericidal concentration) with a range of 32-2048 μg/ml.
Conclusion: In the study of antibacterial activity, a direct and significant relationship between the structure of compounds and antibacterial activity was observed.
Materials & Methods: Six derivatives of [1,3]-Dithiine and a magnetic nanoparticles containing [1,3]-Dithiine were synthesized and antibacterial activity against Loctococcus garvieae were evaluated. Antimicrobial property was assessed using the CLSI (Clinical & Laboratory Standards Institut) standard and compared with gentamicin as a commercial drug.
Results: Synthetic derivatives of [1,3]-Dithiine and magnetic nanoparticles showed acceptable antibacterial effects based on IZD (inhibition zone diameter), MIC (minimum inhibitory concentration), and MBC (minimum bactericidal concentration) with a range of 32-2048 μg/ml.
Conclusion: In the study of antibacterial activity, a direct and significant relationship between the structure of compounds and antibacterial activity was observed.
Keywords: [1, 3]-Dithiine, Antibacterial Activity, Loctococcus Garvieae, Magnetic Nanoparticles, New Heterocyclic Compounds
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