Volume 36, Issue 2 (6-2025)
Studies in Medical Sciences 2025, 36(2): 108-113 |
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Kashef Hesary A, Rezaie J. Protein Corona on Extracellular Vesicles: Formation and Biological Function. Studies in Medical Sciences 2025; 36 (2) :108-113
URL: http://umj.umsu.ac.ir/article-1-6474-en.html
URL: http://umj.umsu.ac.ir/article-1-6474-en.html
Solid Tumor Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran , rezaie.j@umsu.ac.ir
Abstract: (217 Views)
Extracellular Vesicles (EVs) secreted by cells have become important agents of communication between cells. EVs promote tissue repair by transferring their molecular contents to target cells, influencing signaling pathways, metabolic functions, and gene expression. Recent studies indicate that numerous extracellular proteins interact with the surface of EVs dynamically, forming a layer referred to as the protein corona. The protein corona interacts with cell-surface receptors and enhances the specific absorption of EVs, thus affecting their therapeutic efficacy. The wide range of biomolecules can interact with the EVs’ surface, and the thickness of these coronal proteins is significantly different within biological fluids, impacting EVs’ kinetics, docking, uptake, biodistribution, and finally cell signaling. The elimination of the coronavirus protein from EVs remains a primary challenge and requires further study. Understanding the properties of the corona protein and eliminating it will be vital for optimizing cell-free therapies, opening new opportunities for progressing regenerative medicine. This review discusses the biogenesis of EVs and the formation of the protein corona. In addition, this review sheds light on the protein corona of EVs as a key factor influencing the function of EVs.
Type of Study: Review article |
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