Volume 36, Issue 3 (9-2025)
Studies in Medical Sciences 2025, 36(3): 231-237 |
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Ethics code: IR.UMSU.REC.1401.139
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Javanmard F, Rahimi serajgah S. The Frequency of Hematologic Disorders in Children with Celiac Disease at Shahid Motahari Hospital in Urmia. Studies in Medical Sciences 2025; 36 (3) :231-237
URL: http://umj.umsu.ac.ir/article-1-6425-en.html
URL: http://umj.umsu.ac.ir/article-1-6425-en.html
Department of pathology,Faculty of medicine , Urmia university of medical science , Urmia,Iran , javanmard.f@umsu.ac.ir
Abstract: (59 Views)
Background and Objective: Celiac disease is an immune-mediated enteropathy characterized by gluten-induced intestinal mucosal damage that induces immune destruction in genetically susceptible individuals. Among its important and relatively common complications are hematologic disorders. This study statistically evaluated the frequency of hematologic abnormalities in children with celiac disease.
Materials and Methods: In this descriptive cross-sectional study, all children under 16 years of age hospitalized at Shahid Motahari Hospital in Urmia from 2019 to 2021 with biopsy-proven celiac disease according to the Marsh classification were included. The collected data included age, sex, WBC count, hemoglobin level, platelet count, prothrombin time, partial thromboplastin time, and international normalized ratio. All analyses were performed using SPSS version 27.
Results: Among the 67 patients enrolled in the study, 6% had leukocytosis, 11.9% had leukopenia, 10.5% had anemia, 9% had thrombocytosis, and 1.5% had thrombocytopenia. Prothrombin time abnormality was observed in 13.5% of patients, and partial thromboplastin time abnormality in 17.9%. Coagulation disorders were more frequent in girls with celiac disease (p < 0.05).
Conclusion: The most common hematologic abnormality in children with celiac disease was coagulation disorders. A significant association was found between sex and coagulation abnormalities, with girls showing a higher frequency of these disorders.
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