Volume 35, Issue 10 (12-2024)
Studies in Medical Sciences 2024, 35(10): 795-804 |
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Tamjid M, Abdolmaleki A. PROTECTIVE AND RESTORATIVE EFFECTS OF NATURAL COMPOUNDS ON STROKE-INDUCED BRAIN DAMAGE: A NARRATIVE REVIEW. Studies in Medical Sciences 2024; 35 (10) :795-804
URL: http://umj.umsu.ac.ir/article-1-6340-en.html
URL: http://umj.umsu.ac.ir/article-1-6340-en.html
PhD Student, Shahid Beheshti University of Tehran, Department of Animal Sciences and Biotechnology, Faculty of Biological Sciences and Technology, Shahid Beheshti University, Tehran, Iran (Corresponding Author) , mehdi.tm@yahoo.com
Abstract: (467 Views)
Background & Aims: Stroke is the leading cause of death and long-term disability in adults, and ranks among the top causes of death worldwide, after cancer and heart attack. Following a stroke and a decrease in oxygen supply to brain tissue, changes occur in energy production mechanisms, leading to an increase in the production of free radicals. When the production of free radicals increases, the body's defense mechanisms become insufficient, making it possible for the body's biomolecules to be destroyed and cell function to be disrupted, which will ultimately cause a disruption in motor functions.
Materials & Methods: In this review, 70 articles indexed in scientific databases, including ISI, PubMed, and Scopus, were reviewed from 2018 to 2024. Eighty percent of these studies were conducted on animal models, and 20% were clinical studies. Given the importance of the topic, this review focuses on the protective effects of natural compounds on stroke-related damage.
Results: Natural compounds, which have fewer side effects than other stroke-related drugs, may have significant protective effects in the treatment of stroke and improve the damage caused by it by affecting the complex processes that occur during a stroke.
Conclusion: By exhibiting anti-inflammatory effects, preventing edema, and reducing the volume of tissue damage, natural compounds can have protective effects on stroke and warrant further study as an ideal option.
Materials & Methods: In this review, 70 articles indexed in scientific databases, including ISI, PubMed, and Scopus, were reviewed from 2018 to 2024. Eighty percent of these studies were conducted on animal models, and 20% were clinical studies. Given the importance of the topic, this review focuses on the protective effects of natural compounds on stroke-related damage.
Results: Natural compounds, which have fewer side effects than other stroke-related drugs, may have significant protective effects in the treatment of stroke and improve the damage caused by it by affecting the complex processes that occur during a stroke.
Conclusion: By exhibiting anti-inflammatory effects, preventing edema, and reducing the volume of tissue damage, natural compounds can have protective effects on stroke and warrant further study as an ideal option.
Type of Study: Review article |
Subject:
Neuroscience
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