Volume 35, Issue 8 (November 2024)
Studies in Medical Sciences 2024, 35(8): 621-635 |
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Research code: IR.UMA.REC.1403.021
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Siahkohian M, Fasihi L, Ebrahimi-Torkmani B. COMPARISON OF THE EFFECT OF AEROBIC, RESISTANCE, AND COMBINED EXERCISES ON HOMOCYSTEINE SERUM LEVELS, ATHEROGENIC INDEX OF PLASMA, AND CARDIOVASCULAR RISK FACTORS IN PATIENTS WITH TYPE 2 DIABETES. Studies in Medical Sciences 2024; 35 (8) :621-635
URL: http://umj.umsu.ac.ir/article-1-6313-en.html
URL: http://umj.umsu.ac.ir/article-1-6313-en.html
Department of Exercise Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran (Corresponding Author) , ebrahimi.ba96@yahoo.com
Abstract: (244 Views)
Background & Aims: Type 2 diabetes is a chronic non-communicable disease that has emerged as a significant public health issue in many countries and is associated with increased cardiovascular risk factors. Physical activity is a proven intervention for the prevention, management, and treatment of type 2 diabetes. However, differences remain regarding the most effective type and intensity of exercise. The purpose of this study was to compare the effects of aerobic, resistance, and combined exercises on plasma homocysteine levels and selected cardiovascular risk factors in patients with type 2 diabetes.
Materials & Methods: Forty-four individuals with type 2 diabetes, aged 30 to 55 years, participated in this study. Participants were randomly assigned to one of four groups: aerobic, resistance, combined, or control (11 participants in each group). Each training program was performed over 12 weeks, with three sessions per week. Blood samples were collected from all participants one day before and 48 hours after the final training session to measure dependent variables. Data were analyzed using paired t-tests and one-way ANOVA, with a significance level set at p<0.05.
Results: After 12 weeks of exercise intervention, significant reductions were observed in total cholesterol (p=0.001), low-density lipoprotein (p=0.001), and homocysteine (p=0.01) levels in the combined exercise group, while high-density lipoprotein levels increased significantly (p=0.036) in this group. Additionally, homocysteine levels in the aerobic training group (p=0.038) and total cholesterol levels in the resistance training group (p=0.028) decreased significantly. No significant changes were observed in other examined parameters.
Conclusion: The results of this study suggest that combined exercises, through their significant impact on homocysteine reduction, lipid profile improvement, and atherogenic index optimization, can be recommended as an effective intervention for reducing cardiovascular risk factors in patients with type 2 diabetes.
Materials & Methods: Forty-four individuals with type 2 diabetes, aged 30 to 55 years, participated in this study. Participants were randomly assigned to one of four groups: aerobic, resistance, combined, or control (11 participants in each group). Each training program was performed over 12 weeks, with three sessions per week. Blood samples were collected from all participants one day before and 48 hours after the final training session to measure dependent variables. Data were analyzed using paired t-tests and one-way ANOVA, with a significance level set at p<0.05.
Results: After 12 weeks of exercise intervention, significant reductions were observed in total cholesterol (p=0.001), low-density lipoprotein (p=0.001), and homocysteine (p=0.01) levels in the combined exercise group, while high-density lipoprotein levels increased significantly (p=0.036) in this group. Additionally, homocysteine levels in the aerobic training group (p=0.038) and total cholesterol levels in the resistance training group (p=0.028) decreased significantly. No significant changes were observed in other examined parameters.
Conclusion: The results of this study suggest that combined exercises, through their significant impact on homocysteine reduction, lipid profile improvement, and atherogenic index optimization, can be recommended as an effective intervention for reducing cardiovascular risk factors in patients with type 2 diabetes.
Keywords: Exercise, Combined Exercise, Type 2 Diabetes, Lipid Profile, Homocysteine, Atherogenic Index of Plasma
Type of Study: Research |
Subject:
Exercise physiology
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