Volume 35, Issue 3 (June 2024)
Studies in Medical Sciences 2024, 35(3): 182-191 |
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Armin K, Fariba F, Zarei M, Komaki A, Ramezani-Aliakbari F. EFFECT OF OLIVE OIL ON NRF2 GENE EXPRESSION IN THE HEART OF AGED RATS INDUCED BY D-GALACTOSE. Studies in Medical Sciences 2024; 35 (3) :182-191
URL: http://umj.umsu.ac.ir/article-1-6247-en.html
URL: http://umj.umsu.ac.ir/article-1-6247-en.html
Assistant Professor of Physiology, Department of Physiology, School of medicine, Hamadan University of Medical Sciences, Hamadan, Iran (Corresponding Author) , f.ramezani@umsha.ac.ir
Abstract: (874 Views)
Background & Aims: The structure and function of mitochondria are impaired in the aged heart. However, it remains a challenge to find a potent compound to improve cardiac function abnormalities in the elderly. Olive oil (OLO), as an oil rich in unsaturated fatty acids, has various protective effects on the cardiovascular system, including anti-inflammatory and anti-diabetic effects, and reduces blood pressure. In the present study, the protective effects of OLO on heart dysfunction caused by aging were investigated.
Materials & Methods: Male Wistar rats were randomly divided into three groups: control, aged rats induced by D-galactose (D-GAL), and aged rats treated with OLO (D-GAL + OLO). Senescence was induced in rats by intraperitoneal injection of D-GAL at a dose of 150 mg/kg for eight weeks, and the D-Gal+OLO group was treated with oral OLO for eight weeks. The ratio of heart weight to body weight was considered as an index of cardiac hypertrophy. Heart tissues were removed to measure molecular parameters.
Results: Aged rats showed cardiac hypertrophy (## p < 0.01) and a decrease in nuclear factor E2 related factor 2 (Nrf2) gene expression (### p < 0.001) compared to the control group. Treatment with OLO improved cardiac hypertrophy (** p < 0.01) and Nrf2 gene expression (*** p < 0.001).
Conclusion: In general, OLO may have a protective role in aging and cardiac hypertrophy, and its beneficial effects may be related to the improvement of antioxidant status. It is suggested to include OLO in the diet of elderly people and cardiac patients.
Materials & Methods: Male Wistar rats were randomly divided into three groups: control, aged rats induced by D-galactose (D-GAL), and aged rats treated with OLO (D-GAL + OLO). Senescence was induced in rats by intraperitoneal injection of D-GAL at a dose of 150 mg/kg for eight weeks, and the D-Gal+OLO group was treated with oral OLO for eight weeks. The ratio of heart weight to body weight was considered as an index of cardiac hypertrophy. Heart tissues were removed to measure molecular parameters.
Results: Aged rats showed cardiac hypertrophy (## p < 0.01) and a decrease in nuclear factor E2 related factor 2 (Nrf2) gene expression (### p < 0.001) compared to the control group. Treatment with OLO improved cardiac hypertrophy (** p < 0.01) and Nrf2 gene expression (*** p < 0.001).
Conclusion: In general, OLO may have a protective role in aging and cardiac hypertrophy, and its beneficial effects may be related to the improvement of antioxidant status. It is suggested to include OLO in the diet of elderly people and cardiac patients.
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