Volume 34, Issue 6 (September 2023)
Studies in Medical Sciences 2023, 34(6): 330-337 |
Back to browse issues page
Research code: 11277
Ethics code: IR.UMSU.REC.1401.176
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Gaibi S, Mohammad Amini H, Feizollah Zadeh S. INVESTIGATING THE PREVALENCE OF AUTOIMMUNE THYROID DISEASES IN CHILDREN WITH CELIAC DISEASE IN URMIA CITY, IRAN. Studies in Medical Sciences 2023; 34 (6) :330-337
URL: http://umj.umsu.ac.ir/article-1-6036-en.html
URL: http://umj.umsu.ac.ir/article-1-6036-en.html
Assistant Professor of Immunology, Department of Immunology and Genetics, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran (Corresponding Author) , Feizollahzadeh.s@umsu.ac.ir
Abstract: (2142 Views)
Background & Aim: Celiac disease is an autoimmune disorder involving the small intestine caused by gluten consumption. In addition to the complications caused by the involvement of the digestive system, many autoimmune complications, especially autoimmune thyroid diseases, are also common in these patients. The aim of this study was to investigate the prevalence of autoimmune thyroid diseases in celiac children of Urmia for the optimal management of their treatment.
Materials & Methods: In this cross-sectional study, venous blood samples were taken from children living in Urmia whose celiac disease was previously confirmed. Anti-transglutaminase test (anti-tTG-) to confirm the diagnosis, Antithyroid Peroxidase antibody (anti-TPO) and Antithyroglobulin Antibody (anti-TG) tests to screen for autoimmune thyroid disease, and Thyroid stimulating hormone (TSH) test was performed to check thyroid function, all by ELISA method. Data were analyzed using descriptive statistics and chi-square test.
Results: Seventy-seven patients with an average age of 11.84 participated in the study; 30 of them were male and 47 were female. Anti-TPO test was positive in 3.9% and Anti-TG test was positive in 11.7% of the patients, all of whom were female. The difference in both genders regarding Anti-TG was statistically significant (p=0.023). In most of the patients who had positive Anti-TPO, the Anti-TG test was also positive, and a significant positive correlation was seen between these two tests (R=0.82). In 26% of the patients, hypothyroidism and in 1.3% of them, hyperthyroidism was seen. Hypothyroidism was seen in celiac patients in whom Anti-TPO was positive, 66.7% and in those who Anti-TG was positive, hypothyroidism was seen in 45.5%, which were not statistically significant (p=0.12).
Conclusion: The results of this study showed that thyroid autoimmune diseases are high in celiac children, especially in females. Therefore, regular examination of thyroid function and monitoring autoantibodies in celiac patients seems necessary for optimal management of both conditions.
Materials & Methods: In this cross-sectional study, venous blood samples were taken from children living in Urmia whose celiac disease was previously confirmed. Anti-transglutaminase test (anti-tTG-) to confirm the diagnosis, Antithyroid Peroxidase antibody (anti-TPO) and Antithyroglobulin Antibody (anti-TG) tests to screen for autoimmune thyroid disease, and Thyroid stimulating hormone (TSH) test was performed to check thyroid function, all by ELISA method. Data were analyzed using descriptive statistics and chi-square test.
Results: Seventy-seven patients with an average age of 11.84 participated in the study; 30 of them were male and 47 were female. Anti-TPO test was positive in 3.9% and Anti-TG test was positive in 11.7% of the patients, all of whom were female. The difference in both genders regarding Anti-TG was statistically significant (p=0.023). In most of the patients who had positive Anti-TPO, the Anti-TG test was also positive, and a significant positive correlation was seen between these two tests (R=0.82). In 26% of the patients, hypothyroidism and in 1.3% of them, hyperthyroidism was seen. Hypothyroidism was seen in celiac patients in whom Anti-TPO was positive, 66.7% and in those who Anti-TG was positive, hypothyroidism was seen in 45.5%, which were not statistically significant (p=0.12).
Conclusion: The results of this study showed that thyroid autoimmune diseases are high in celiac children, especially in females. Therefore, regular examination of thyroid function and monitoring autoantibodies in celiac patients seems necessary for optimal management of both conditions.
Keywords: Autoimmunity, Anti-Thyroglobulin Antibody, Anti-Thyroid Peroxidase Antibody, Celiac Disease, Thyroid, Tissue Transglutaminase
Type of Study: Research |
Subject:
گوارش کودکان
References
1. Gujral N, Freeman HJ, Thomson AB. Celiac disease: prevalence, diagnosis, pathogenesis and treatment. World J Gastroenterol 2012;18(42):6036-59. [DOI:10.3748/wjg.v18.i42.6036] [PMID] [PMCID]
2. Elmdaah AKA. Coeliac disease etiology and pathogenesis. Libyan J Med Sci 2021;5.1: 2-5.
https://doi.org/10.4103/LJMS.LJMS_87_20 [DOI:10.4103/ljms.ljms_87_20]
3. Green PH, Jabri B. Coeliac disease. Lancet 2003;362(9381):383-91.
https://doi.org/10.1016/S0140-6736(03)14027-5 [DOI:10.1016/s0140-6736(03)14027-5] [PMID]
4. Holmes G. Coeliac disease and type 1 diabetes mellitus-the case for screening. Diabet Med 2001;18(3):169-77. [DOI:10.1046/j.1464-5491.2001.00498.x] [PMID]
5. Malamut G, Cellier C. Complications of coeliac disease. Best Pract Res Clin Gastroenterol 2015;29(3):451-8. [DOI:10.1016/j.bpg.2015.05.005] [PMID]
6. Goddard C, Gillett H. Complications of coeliac disease: are all patients at risk? Postgrad Med J 2006;82(973):705-12. [DOI:10.1136/pgmj.2006.048876] [PMID] [PMCID]
7. Lundin KE, Wijmenga C. Coeliac disease and autoimmune disease-genetic overlap and screening. Nat Rev Gastroenterol Hepatol 2015;12(9):507-15. [DOI:10.1038/nrgastro.2015.136] [PMID]
8. Hakanen M, Luotola K, Salmi J, Laippala P, Kaukinen K, Collin P. Clinical and subclinical autoimmune thyroid disease in adult celiac disease. Dig Dis Sci 2001;46:2631-5.
https://doi.org/10.1023/A:1012754824553 [DOI:10.1023/a:1012754824553] [PMID]
9. Counsell C, Taha A, Ruddell W. Coeliac disease and autoimmune thyroid disease. Gut 1994;35(6):844-6. [DOI:10.1136/gut.35.6.844] [PMID] [PMCID]
10. Ansaldi N, Palmas T, Corrias A, Barbato M, D'Altiglia MR, Campanozzi A, et al. Autoimmune thyroid disease and celiac disease in children. J Pediatr Gastroenterol Nutr 2003;37(1):63-6. [DOI:10.1097/00005176-200307000-00010] [PMID]
11. Hadithi M, de Boer H, Meijer JW, Willekens F, Kerckhaert JA, Heijmans R, et al. Coeliac disease in Dutch patients with Hashimoto's thyroiditis and vice versa. World J Gastroenterol 2007;13(11): 1715-22. [DOI:10.3748/wjg.v13.i11.1715] [PMID] [PMCID]
12. Saleem A, Connor HO, Regan PO. Adult coeliac disease in Ireland: a case series. Ir J Med Sci 2012;181:225-9. [DOI:10.1007/s11845-011-0788-z] [PMID]
13. Midhagen G, Järnerot G, Kraaz W. Adult coeliac disease within a defined geographic area in Sweden: a study of prevalence and associated diseases. Scand J Gastroenterol 1988;23(8):1000-4. [DOI:10.3109/00365528809090160] [PMID]
14. Tomer Y, Huber A. The etiology of autoimmune thyroid disease: a story of genes and environment. J Autoimmun 2009;32(3-4):231-9. [DOI:10.1016/j.jaut.2009.02.007] [PMID] [PMCID]
15. Mammen JS, Cappola AR. Autoimmune thyroid disease in women. Jama 2021;325(23):2392-3. [DOI:10.1001/jama.2020.22196] [PMID] [PMCID]
16. Ai J, Leonhardt JM, Heymann WR. Autoimmune thyroid diseases: etiology, pathogenesis, and dermatologic manifestations. J Am Acad Dermatol 2003;48(5):641-62. [DOI:10.1067/mjd.2003.257] [PMID]
17. Elfström P, Montgomery SM, Kämpe O, Ekbom A, Ludvigsson JF. Risk of thyroid disease in individuals with celiac disease. J Clin Endocrinol Metab 2008;93(10):3915-21. [DOI:10.1210/jc.2008-0798] [PMID]
18. Kumar V, Rajadhyaksha M, Wortsman J. Celiac disease-associated autoimmune endocrinopathies. Clin diagn lab immunol 2001;8(4):678-85.
https://doi.org/10.1128/CDLI.8.4.678-685.2001 [DOI:10.1128/cdli.8.4.678-685.2001] [PMID] [PMCID]
19. Barone MV, Troncone R, Auricchio S. Gliadin peptides as triggers of the proliferative and stress/innate immune response of the celiac small intestinal mucosa. Int J Mol Sci 2014;15(11):20518-37. [DOI:10.3390/ijms151120518] [PMID] [PMCID]
20. Collin P, Kaukinen K, Välimäki M, Salmi J. Endocrinological disorders and celiac disease. Endocr Rev 2002;23(4):464-83. [DOI:10.1210/er.2001-0035] [PMID]
21. Kelly CP, Bai JC, Liu E, Leffler DA. Advances in diagnosis and management of celiac disease. Gastroenterology 2015;148(6):1175-86. [DOI:10.1053/j.gastro.2015.01.044] [PMID] [PMCID]
22. Canova C, Pitter G, Ludvigsson JF, Romor P, Zanier L, Zanotti R, et al. Celiac Disease and Risk of Autoimmune Disorders: A Population-Based Matched Birth Cohort Study. J Pediatr 2016;174:146-52 e1. [DOI:10.1016/j.jpeds.2016.02.058] [PMID]
23. Weihl C. The thyroid gland; a pediatric review. Ohio State Med J 1954;50(11):1044-7. [] [PMID]
24. Siriwardhane T, Krishna K, Ranganathan V, Jayaraman V, Wang T, Bei K, et al. Significance of anti-TPO as an early predictive marker in thyroid disease. Autoimmune Dis 2019;2019:1684074. [DOI:10.1155/2019/1684074] [PMID] [PMCID]
25. Kalyoncu D, Urganci N. Antithyroid antibodies and thyroid function in pediatric patients with celiac disease. Int J Endocrinol 2015; 2015:276575. [DOI:10.1155/2015/276575] [PMID] [PMCID]
26. Toscano V, Conti F, Anastasi E, Mariani P, Tiberti C, Poggi M, et al. Importance of gluten in the induction of endocrine autoantibodies and organ dysfunction in adolescent celiac patients. Am J Gastroenterol 2000;95(7):1742-8. [DOI:10.1111/j.1572-0241.2000.02187.x] [PMID]
27. Simmonds M, Gough S. The HLA region and autoimmune disease: associations and mechanisms of action. Curr Genomics 2007;8(7):453-65. [DOI:10.2174/138920207783591690] [PMID] [PMCID]
28. Lee HJ, Li CW, Hammerstad SS, Stefan M, Tomer Y. Immunogenetics of autoimmune thyroid diseases: a comprehensive review. J Autoimmun 2015;64:82-90. [DOI:10.1016/j.jaut.2015.07.009] [PMID] [PMCID]
29. Sun X, Lu L, Yang R, Li Y, Shan L, Wang Y. Increased incidence of thyroid disease in patients with celiac disease: a systematic review and meta-analysis. PloS one 2016;11(12):e0168708. [DOI:10.1371/journal.pone.0168708] [PMID] [PMCID]
30. Toumi D, Mankai A, Belhadj R, Ghedira-Besbes L, Jeddi M, Ghedira I. Thyroid-related autoantibodies in Tunisian patients with coeliac disease. Clin Chem Lab Med 2008;46(3):350-3.
https://doi.org/10.1515/CCLM.2008.075 [DOI:10.1515/cclm.2008.075] [PMID]
31. Van der Pals M, Ivarsson A, Norström F, Högberg L, Svensson J, Carlsson A. Prevalence of thyroid autoimmunity in children with celiac disease compared to healthy 12-year olds. Autoimmune Dis 2014;2014:417356. [DOI:10.1155/2014/417356] [PMID] [PMCID]
32. Meloni A, Mandas C, Jores RD, Congia M. Prevalence of autoimmune thyroiditis in children with celiac disease and effect of gluten withdrawal. J Pediatr 2009;155(1):51-5, 55.e1. [DOI:10.1016/j.jpeds.2009.01.013] [PMID]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
