Volume 34, Issue 7 (10-2023)
Studies in Medical Sciences 2023, 34(7): 408-416 |
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Ethics code: IR.MUI.MED.REC.1399.021
Clinical trials code: IRCT20200413047059N1
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Ali Kiaei B, Hashemi S T, Fatemi Y, Shatabi H. COMPARISON OF THE EFFECT OF CHLORHEXIDINE MOUTHWASH WITH DINEH HERBAL MOUTHWASH IN PREVENTING VENTILATOR-ASSOCIATED PNEUMONIA IN THE PATIENTS ADMITTED TO THE INTENSIVE CARE UNIT. Studies in Medical Sciences 2023; 34 (7) :408-416
URL: http://umj.umsu.ac.ir/article-1-5996-en.html
URL: http://umj.umsu.ac.ir/article-1-5996-en.html
Associate Professor, Department of Anesthesiology, Isfahan University of Medical Sciences, Isfahan, Iran (Corresponding Author) , hamidshetabi@med.mui.ac.ir
Abstract: (1993 Views)
Background & Aim: Consumption of mouthwashes is effective in reducing ventilator-associated pneumonia in the patients hospitalized in the Intensive Care Unit. Considering the importance of controlling and preventing the occurrence of ventilator-associated pneumonia, it was decided to compare the effect of chlorhexidine mouthwash with Dinah herbal mouthwash in preventing ventilator-associated pneumonia in patients hospitalized in the Intensive Care Unit.
Materials & Methods: In this clinical trial study, 80 patients hospitalized in the intensive care unit were included in the study in two groups of receiving chlorhexidine gluconate 0.2% and Dineh mouthwash. The frequency, time, and method of mouthwash in both groups were performed three times a day (every eight hours) for 5 days. The incidence of ventilator-associated pneumonia and mortality in the patients after taking drugs were investigated. Finally, the information was entered into SPSS 23 software and analyzed.
Results: There were 21 female patients (52.5%) and 19 male patients (47.5%) in the chlorhexidine group, and 18 female patients (45%) and 22 male patients (55%) in the Dina group (p=0.655). The average age in the chlorhexidine group was 60.85±7.92 years and in the Dineh group was 57.68±6.93 years (p=0.060). The incidence of ventilator-associated pneumonia was 10% in the chlorhexidine group and 12.5% in the Dinah group (P=0.999). The outcome of the patients in the chlorhexidine group was 62.5% complete recovery, 32.5% recovery with complications, and 0.5% death, and in the Dina group, 70% complete recovery, 20% recovery with complications, and 10% death (p=0 /363).
Conclusion: In the patients under mechanical ventilation, Dinah mouthwash was not superior to chlorhexidine mouthwash in preventing ventilator-associated pneumonia.
Materials & Methods: In this clinical trial study, 80 patients hospitalized in the intensive care unit were included in the study in two groups of receiving chlorhexidine gluconate 0.2% and Dineh mouthwash. The frequency, time, and method of mouthwash in both groups were performed three times a day (every eight hours) for 5 days. The incidence of ventilator-associated pneumonia and mortality in the patients after taking drugs were investigated. Finally, the information was entered into SPSS 23 software and analyzed.
Results: There were 21 female patients (52.5%) and 19 male patients (47.5%) in the chlorhexidine group, and 18 female patients (45%) and 22 male patients (55%) in the Dina group (p=0.655). The average age in the chlorhexidine group was 60.85±7.92 years and in the Dineh group was 57.68±6.93 years (p=0.060). The incidence of ventilator-associated pneumonia was 10% in the chlorhexidine group and 12.5% in the Dinah group (P=0.999). The outcome of the patients in the chlorhexidine group was 62.5% complete recovery, 32.5% recovery with complications, and 0.5% death, and in the Dina group, 70% complete recovery, 20% recovery with complications, and 10% death (p=0 /363).
Conclusion: In the patients under mechanical ventilation, Dinah mouthwash was not superior to chlorhexidine mouthwash in preventing ventilator-associated pneumonia.
Keywords: Ventilator-Associated Pneumonia, Chlorhexidine Mouthwash, Dinah Herbal Mouthwash, Intensive Care Unit
Type of Study: Clinical trials |
Subject:
Anesthesia
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