Volume 32, Issue 7 (October 2021)
Studies in Medical Sciences 2021, 32(7): 490-499 |
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Moghadami F, Kalantari M. INVESTIGATION OF ANTIBACTERIAL ACTIVITY OF IRON OXIDE NANOPARTICLES IN COMBINATION WITH LAVENDER (LAVANDULA ANGUSTIFOLIA) LEAF EXTRACT BY RESPONSE SURFACE METHODOLOGY. Studies in Medical Sciences 2021; 32 (7) :490-499
URL: http://umj.umsu.ac.ir/article-1-5351-en.html
URL: http://umj.umsu.ac.ir/article-1-5351-en.html
Assistant Professor of Microbiology, Department of Biology, Payame Noor University, Tehran, Iran (Corresponding Author) , fouziehm@yahoo.com
Abstract: (2941 Views)
Background & Aims: Bacterial resistance to antibiotic treatment is a dilemma that has led researchers to search for suitable alternatives. The use of herbs and nanotechnology can be a solution. This study aimed to investigate the antimicrobial activity of iron oxide nanoparticles in combination with lavender leaf extract using response surface methodology.
Materials & Methods: The response surface methodology and a central composite design were employed to evaluate the iron oxide nanoparticle and lavender extract's antibacterial activity at different temperatures against E.coli and S.aureus. The agar well diffusion method was used to determine the antibacterial activity.
Results: The results showed that the antimicrobial effect of iron oxide nanoparticles was greater than lavender extract. The response of the two tested bacteria to the combination of iron oxide nanoparticles and lavender extract was not the same at different temperatures. The antimicrobial effect of iron oxide nanoparticles in combination with lavender extract on the growth of S.aureus was greater than their effect on E.coli. On the other hand, increasing the temperature increased the antimicrobial properties of the combination of iron oxide nanoparticles and lavender extract against E.coli, but did not affect S.aureus.
Conclusion: According to the results, it can be concluded that iron oxide nanoparticles in combination with lavender extract can be a suitable option as an antimicrobial agent in topical or oral applications. However, more comprehensive studies and clinical trials are needed.
Materials & Methods: The response surface methodology and a central composite design were employed to evaluate the iron oxide nanoparticle and lavender extract's antibacterial activity at different temperatures against E.coli and S.aureus. The agar well diffusion method was used to determine the antibacterial activity.
Results: The results showed that the antimicrobial effect of iron oxide nanoparticles was greater than lavender extract. The response of the two tested bacteria to the combination of iron oxide nanoparticles and lavender extract was not the same at different temperatures. The antimicrobial effect of iron oxide nanoparticles in combination with lavender extract on the growth of S.aureus was greater than their effect on E.coli. On the other hand, increasing the temperature increased the antimicrobial properties of the combination of iron oxide nanoparticles and lavender extract against E.coli, but did not affect S.aureus.
Conclusion: According to the results, it can be concluded that iron oxide nanoparticles in combination with lavender extract can be a suitable option as an antimicrobial agent in topical or oral applications. However, more comprehensive studies and clinical trials are needed.
Type of Study: Research |
Subject:
میکروبیولوژی
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