D Maleki [1] , MD S Hejazy [2] , MD M Karamyar [3] , MD

 Received: 22 April, 2007 Accepted: 2 June, 2008

 Abstract

 Adult T-cell leukemia/lymphoma (ATLL) is a lymph proliferative neoplasm caused by human T-lymph tropic virus type 1 (HTLV-1), which is also the etiologic agent^�of HTLV-1-associated with myelopathy or tropical spastic para paresis.^�HTLV-1 is distributed worldwide, but is endemic only^�in certain parts of the world such as southwestern Japan, the^�Caribbean, Africa, parts of South America and Khorasan, the northeastern^�province of Iran.

 We describe two patients, one male and one female, respectively 45 and 53 years old and born in Urmia with clinical, laboratory, and morphologic finding characteristics of ATLL, and anti-HTLV-1 positive serums. Both diagnosed and treated as ATLL by chemotherapy and expired 9 months after the diagnosis.

 Our findings confirm the presence of HTLV-1 in West Azerbaijan . With respect to that, there is no defined treatment for HTLV-1 infection and its complications, so studies to determine the prevalence rates may be necessary in establishing prophylactic^�measures to reduce the rates of viral transmission.

  Keywords: Human T-lymph tropic virus type 1, Adult T-cell leukemia/lymphoma, Endemic

  Address : Imam Khomeini Hospital, Urmia, Iran Tel: 09144431632

 E-mail: davood.maleki@gmail.com

  Source: UMJ 2008: 19( 3 ): 288 ISSN: 1027-3727

  [1] Assistant Professor of Internal Disease, Urmia University of Medical Sciences (Corresponding Author)

  [2] Assistant Professor of Pediatric Disease, Urmia University of Medical Sciences

  [3] Assistant Professor of Pediatric Disease, Urmia University of Medical Sciences