Volume 24, Issue 5 (Monthly August 2013)                   Studies in Medical Sciences 2013, 24(5): 309-317 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Entezariasl M, Isazadehfar K. COMPARISON OF PETHIDINE AND DEXAMETHASONE IN PREVENTING POSTOPERATIVE SHIVERING. Studies in Medical Sciences. 2013; 24 (5) :309-317
URL: http://umj.umsu.ac.ir/article-1-1768-en.html
EDC Center, Ardabil University of Medical Sciences, Ardabil, Iran , isazadehfar@yahoo.com
Abstract:   (10053 Views)

Received: 9 Apr , 2013 Accepted: 9 Jun , 2013




Background & Aims: Post-operative shivering is very common and it is usually followed by many problems such as an increase in oxygen consumption, blood pressure, intracranial and intraocular pressure, and post-operation pain. Therefore, it is very important to prevent shivering especially in the elderly and ischemic heart disease patients. The goal of this study was comparing the effect of Pethidine (Meperidine), Dexamethasone, and Placebo in prevention of shivering.


Materials & Methods: This double blind clinical trial study was carried out on 120 patients who were candidates for surgery under general anesthesia.The patients were randomly divided into three groups including those who received placebo (a) Dexamethasone (b) and Pethidine (c). Induction and maintenance of anesthesia for all patients were similar. Central and peripheral temperature of patients was measured every 5 minute interval. After induction saline normal, Dexamethasone and Pethidine were respectively injected to groups a, b, and c. In recovery, all patients were controlled for visible shivering: The data were statistically analyzed by SPSS software and ANOVA and chi square tests.


Results: There were no significant differences among three mentioned groups regarding of gender, age, duration of surgery, and recovery time.  Nineteen cases (47.5%) in group a had post-operative shivering. Whereas, in group b only 4 cases (10%) had shivering and the difference between 2 groups was significant (P value = 0.001). Also in group c, 15 cases (37.5%) had shivering that the difference with placebo group was significant (P value = 0.08).


Conclusion: The present study showed that pethidine and dexamethasone are effective drugs for preventing post-operative shivering in elective surgery. And the effect of dexamethasone in preventing the post-operative shivering is better than Pethidine. Dexamethasone can be administered after induction of anesthesia as an alternative to administration of Pethidine (as a common method of prevention and treatment of postoperative shivering) particularly in patients with hemodynamic instability.

Full-Text [PDF 166 kb]   (2763 Downloads)    
Type of Study: Research | Subject: آناتومی

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2022 CC BY-NC 4.0 | Studies in Medical Sciences

Designed & Developed by : Yektaweb