Background & Aims: Endothelial dysfunction is found in early steps of atherosclerosis and is related with diseases such as hypertension, dyslipidemia, and insulin resistance. Insulin resistance is related to metabolic abnormalities .We aimed to examine influence of impaired fasting glucose on endothelial function biomarkers and biochemistry biomarkers in metabolic syndrome patients.

Materials & Methods: This study was conducted on 80 patients with metabolic syndrome (MS) diagnosed based on the NCEP Adult Treatment Panel III. Subjects were divided into two groups 36 MS patients with Fasting Blood Sugar (FBS) ≥ 100 mg/dl and 44 patients with FBS <100 mg/dl. In order to evaluate endothelial function, plasma Endothelin-1 , intercellular adhesion molecule (ICAM-1), E-selectin, (NO₂^▬) and Nitrate ) NO₃^▬) concentrations were measured.

Results: The mean age in patients with FBS ≥ 100 mg/dl and <100 mg/dl were 51.58 ± 8.82 and 46.77 ± 10.46 years, respectively. ( P= 0.031) In cholesterol, LDL-c, HDL-c, levels were similar in two groups. E-selectin plasma level was significantly higher in patients with FBS ≥100 mg/dl (11.67±4.81 ) compared with patients with FBS <100 mg/dl (9.61 ± 4.41 p= 0.049) and in patients with FBS ≥100 mg/dl NO₂^-, NO₃^- were 15. 85 ± 4.67, 16.96 ± 6.3 uM, respectively and in patients with FBS <100 mg/dl were 19.65 ± 7.41, 21.25 ± 10.81 respectively, in NO₂^- p= 0.010, in NO₃ p= 0.039 that were significantly lower compared with patients with FBS <100 mg/dl. Endothelin-1 and ICAM-1 were similar in two groups.

Conclusions: MS patients with impaired fasting glucose had higher level of E-selectin and this factor may induce endothelial dysfunction. Insulin resistance may increase NO₂^- and NO₃^- in MS patients with high FBS. 

SOURCE: URMIA MED J 2012: 23(4): 459 ISSN: 1027-3727