Volume 30, Issue 5 (August 2019)                   J Urmia Univ Med Sci 2019, 30(5): 355-363 | Back to browse issues page

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Ilkhanizadeh B, Mazloomi E, kheradmand F, Rezapour-Firouzi S, Delirezh N, Shahabi S. Evaluation of the Effects of Nicotine on Mammalian Target of Rapamycin Complex 2 and Signal Transducer and Activator of Transcription 3 Genes Expression in a Mouse Model of Allergic Asthma: An experimental study. J Urmia Univ Med Sci. 2019; 30 (5) :355-363
URL: http://umj.umsu.ac.ir/article-1-4664-en.html
Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran , Ebrahim.mazloomi@gmail.com
Abstract:   (297 Views)
Background & Aims: Allergic diseases have increased in the last decade worldwide and researchers have been trying to introduce new strategies and drugs to treat these types of diseases. Nicotine shows anti-inflammatory properties and the studies have revealed that it can reduce the inflammation and the allergic responses. The mammalian target of rapamycin (mTOR) is a multifunctional protein kinase that forms two complexes in the signaling pathway. It has been shown that mTOR Complex 2 (mTORC2) tends to promote the immune response toward Th2. Also, the studies have indicated that the signal transducer and activator of transcription 3 (STAT3) is an essential transcription factor in anti-inflammatory responses and nicotine exert its anti-inflammatory effects using the STAT3 signaling pathway
Materials & Methods: In this experimental Study, we investigated the effects of nicotine on the expression RICTOR-mTORC2 and STAT3 genes in a mouse model of allergic asthma. The mice were sensitized using ovalbumin and alum and 2 weeks later treated tree times with nicotine in the concentration of 10 mg/kg every other day. The mice were challenged with ovalbumin aerosols on days 35, 38 and 41 and sacrificed the next day
Results: Our results showed that nicotine treatment resulted in down-regulation of RICTOR-mTORC2 expression. Also, the results indicated that nicotine could up-regulate the expression of STAT3
Conclusion: Such data proposed that nicotine administration may decrease allergic responses and the inflammation in the airways of the allergic mice by down-regulating the expression of RICTOR-mTORC2 and up-regulating the expression of STAT3 genes.
Keywords: Allergy, Nicotine, mTORC2, STAT3
Full-Text [PDF 460 kb]   (163 Downloads)    
Type of Study: Research | Subject: ایمونولوژی

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