Volume 27, Issue 4 (Monthly_jul 2016)                   J Urmia Univ Med Sci 2016, 27(4): 257-265 | Back to browse issues page

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Mohammadi A, Mansoori B, ghakaboodi K C, Baradaran B. CYTOTOXIC EFFECTS OF ANACYCLUS PYRETHRUM PLANT EXTRACT IN ORAL CANCER CELL (KB CELL LINE). J Urmia Univ Med Sci. 2016; 27 (4) :257-265
URL: http://umj.umsu.ac.ir/article-1-3490-en.html
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran , Behzad_im@yahoo.com
Abstract:   (4649 Views)

Background & Aims: Cancer is one of the most causes of mortality worldwide. Products derived from natural plants that induce apoptosis are used for cancer treatment. Therefore investigation of different herbal components for new anti-cancer drug is one of the main research activities throughout the world. This study is the first to investigate the cytotoxic and apoptotic effect of Anacyclus pyrethrum plants extract in KB cancer cell lines.

Materials & Methods: Cytotoxic effects of Anacyclus pyrethrum plant extract was measured using MTT assays. To show induction of apoptosis by this plant TUNNEL assay and DNA Fragmentation were performed.

Results: In the present study, Anacyclus pyrethrum extract noticeably killed cancer cells. TUNNEL test and DNA Fragmentation assay showed apoptotic characteristic in Anacyclus pyrethrum extract treated cells.

Conclusion: Our studies revealed that ethanol extracts of Anacyclus pyrethrum is effective in apoptosis inducing in KB cancer cells which may be beneficial in cancer therapy.

 

SOURCE: URMIA MED J 2016: 27(4): 265 ISSN: 1027-3727

Full-Text [PDF 545 kb]   (1540 Downloads)    
Type of Study: Research | Subject: ایمونولوژی

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