Volume 34, Issue 4 (July 2023)
Studies in Medical Sciences 2023, 34(4): 196-205 |
Back to browse issues page
Research code: A-10-5364-1
Ethics code: IR.PNU.REC.1401.484
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Parandin R, Abbasi F. ANTIDEPRESSANT EFFECTS OF ROYAL JELLY USING MICE MODEL OF DEPRESSION INDUCED BY RESERPINE. Studies in Medical Sciences 2023; 34 (4) :196-205
URL: http://umj.umsu.ac.ir/article-1-5960-en.html
URL: http://umj.umsu.ac.ir/article-1-5960-en.html
Department of Biology, Payame Noor University, Tehran, Iran (Corresponding Author) , rahmatparandin@pnu.ac.ir
Abstract: (1402 Views)
Background & Aims: The studies have shown that some natural components have antidepressant effects. The aim of this study was to investigate the effects of administration of royal jelly as a secretion nutrient derived from the salivary glands of worker bees on some depressive behaviors, total antioxidant capacity (TAC) and malondialdehyde (MDA) level in mice in which depression was induced by Reserpine.
Materials & Methods: In this experimental study, 42 male mice were divided into 6 groups of 7, including control (normal saline), reserpine (negative control), fluoxetine (positive control), and three reserpine groups treated with 100, 200, and 400 mg/kg of royal jelly via the intraperitoneal route. In order to investigate depression, forced swimming and tail suspension tests which are forms of behavioral despair were used. Brain TAC and MDA levels were also determined. The data were analyzed by SPSS statistical software and OneWay ANOVA test at a significance level of p<0.05.
Results: Reserpine treatment significantly increased the time of immobility in the forced swimming and tail suspension tests. Royal jelly significantly reduced the immobility time in both behavioral tests at 200 and 400 mg/kg doses. Reserpine treatment significantly decreased brain TAC and increased MDA levels in the brain. Royal jelly at 200 and 400 mg/kg significantly increased brain TAC and reduced the MDA level.
Conclusion: It seems that the royal jelly has a significant potential in reducing symptoms of depression and brain oxidative stress, which may be due to its ingredients.
Materials & Methods: In this experimental study, 42 male mice were divided into 6 groups of 7, including control (normal saline), reserpine (negative control), fluoxetine (positive control), and three reserpine groups treated with 100, 200, and 400 mg/kg of royal jelly via the intraperitoneal route. In order to investigate depression, forced swimming and tail suspension tests which are forms of behavioral despair were used. Brain TAC and MDA levels were also determined. The data were analyzed by SPSS statistical software and OneWay ANOVA test at a significance level of p<0.05.
Results: Reserpine treatment significantly increased the time of immobility in the forced swimming and tail suspension tests. Royal jelly significantly reduced the immobility time in both behavioral tests at 200 and 400 mg/kg doses. Reserpine treatment significantly decreased brain TAC and increased MDA levels in the brain. Royal jelly at 200 and 400 mg/kg significantly increased brain TAC and reduced the MDA level.
Conclusion: It seems that the royal jelly has a significant potential in reducing symptoms of depression and brain oxidative stress, which may be due to its ingredients.
References
1. Kukuia KKE, Mante PK, Woode E, Ameyaw EO, Adongo DW. Antidepressant effects of mallotus oppositifolius in acute murine models. Int Sch Res Not 2014;2014. [DOI:10.1155/2014/324063] [PMID] [PMCID]
2. Wilson E, Lader M. A review of the management of antidepressant discontinuation symptoms. Ther Adv Psychopharmacol 2015;5(6):357-68. [DOI:10.1177/2045125315612334] [PMID] [PMCID]
3. Montazeri A, Mousavi SJ, Omidvari S, Tavousi M, Hashemi A, Rostami T. Depression in Iran: a systematic review of the literature (2000-2010). Payesh 2013;12(6):567-94. [Google Scholar]
4. Spence R, Roberts A, Ariti C, Bardsley M. Focus on: antidepressant prescribing. Heal Found Nuff Trust 2014 [URL]
5. Onasanwo SA, Chatterjee M, Palit G. Antidepressant and anxiolytic potentials of dichloromethane fraction from Hedranthera barteri. Afr J Biomed Res 2010;13(1):76-81. [Google Scholar]
6. de Oliveira MR, Chenet AL, Duarte AR, Scaini G, Quevedo J. Molecular mechanisms underlying the anti-depressant effects of resveratrol: a review. Mol Neurobiol 2018;55:4543-59. [DOI:10.1007/s12035-017-0680-6] [PMID]
7. Nakajima Y, Tsuruma K, Shimazawa M, Mishima S, Hara H. Comparison of bee products based on assays of antioxidant capacities. BMC Complement Altern Med 2009;9(1):1-9. [DOI:10.1186/1472-6882-9-4] [PMID] [PMCID]
8. Hashimoto M, Kanda M, Ikeno K, Hayashi Y, Nakamura T, Ogawa Y, et al. Oral administration of royal jelly facilitates mRNA expression of glial cell line-derived neurotrophic factor and neurofilament H in the hippocampus of the adult mouse brain. Biosci Biotechnol Biochem 2005;69(4):800-5. [DOI:10.1271/bbb.69.800] [PMID]
9. Sofiabadi M, Esmaeili M, Haghdoost-Yazdi H, Aali M. The effect of royal jelly on the learning and memory of streptozotocin-diabetic male rats. J Ardabil Univ Med Sci 2017;17(3):324-33. [Google Scholar]
10. Jie H, Li PM, Zhao GJ, Feng XL, Zeng DJ, Zhang CL, et al. Amino acid composition of royal jelly harvested at different times after larval transfer. Genet Mol Res 2016;15(3). [DOI:10.4238/gmr.15038306] [PMID]
11. Mohamed AA-R, Galal AAA, Elewa YHA. Comparative protective effects of royal jelly and cod liver oil against neurotoxic impact of tartrazine on male rat pups brain. Acta Histochem 2015;117(7):649-58. [DOI:10.1016/j.acthis.2015.07.002] [PMID]
12. Rabiei Z, Movahedi E, Rafieian Kopaei M, Lorigooini Z. Antidepressant effects of Trifolium pratense hydroalcholic extract in mice. Iran J Physiol Pharmacol 2018;2(1):24-33. [Google Scholar]
13. Rabiei Z, Mokhtari S, Babaei F, Rafieian-Kopaei M. Effect of kombucha tea on depression and motor activity in mice. J Med Plants 2017;16(61):156-66. [Google Scholar]
14. Samani BH, Khoshtaghaza MH, Lorigooini Z, Minaei S, Zareiforoush H. Analysis of the combinative effect of ultrasound and microwave power on Saccharomyces cerevisiae in orange juice processing. Innov Food Sci Emerg Technol 2015;32:110-5. [DOI:10.1016/j.ifset.2015.09.015]
15. Lori-Gooini Z, Rabiei Z, Farhadi B, Bijad E, Azomon E, Rafieian-Kopaei M. Investigation of chemical compounds and effects of Achilea wilhelmsii L essential oil on antioxidant and malondialdehyde levels of serum and brains of reserpined mice. Iran J Physiol Pharmacol 2018;2(3):166-76. [Google Scholar]
16. Hashemi SF, Namjou A, Ghasemi PA, Lorigooini Z, Rafieian KM, Gholami AM. Antidepressant-like effect of Lavandula angustifolia Mill and Citrus aurantium Duh essential oils with forced swimming test in reserpinized mice balb/c. 2017 [URL]
17. Emamghoreishi M, Talebianpour MS. Antidepressant effect of Melissa officinalis in the forced swimming test. DARU J Pharm Sci 2015;17(1):42-7. [Google Scholar]
18. Ikram H, Haleem DJ. Repeated treatment with reserpine as a progressive animal model of depression. Pak J Pharm Sci 2017;30(3). [Google Scholar]
19. Hillhouse TM, Porter JH. A brief history of the development of antidepressant drugs: from monoamines to glutamate. Exp Clin Psychopharmacol 2015;23(1):1. [DOI:10.1037/a0038550] [PMID] [PMCID]
20. Dwivedi G, Tomar V. Protective effect of Ipomoea aquatica against reserpine induced oxidative stress in brain using mice. Int J Basic Clin Pharmacol 2016;5(5):2123-9. [DOI:10.18203/2319-2003.ijbcp20163248]
21. Sarandol A, Sarandol E, Eker SS, Erdinc S, Vatansever E, Kirli S. Major depressive disorder is accompanied with oxidative stress: short‐term antidepressant treatment does not alter oxidative-antioxidative systems. Hum Psychopharmacol Clin Exp 2007;22(2):67-73. [DOI:10.1002/hup.829] [PMID]
22. Sasaki K. Nutrition and dopamine: An intake of tyrosine in royal jelly can affect the brain levels of dopamine in male honeybees (Apis mellifera L.). J Insect Physiol 2016;87:45-52. [DOI:10.1016/j.jinsphys.2016.02.003] [PMID]
23. Pyrzanowska J, Piechal A, Blecharz-Klin K, Joniec-Maciejak I, Graikou K, Chinou I, et al. Long-term administration of Greek Royal Jelly improves spatial memory and influences the concentration of brain neurotransmitters in naturally aged Wistar male rats. J Ethnopharmacol 2014;155(1):343-51. [DOI:10.1016/j.jep.2014.05.032] [PMID]
24. Hattori N, Ohta S, Sakamoto T, Mishima S, Furukawa S. Royal jelly facilitates restoration of the cognitive ability in trimethyltin-intoxicated mice. Evidence-based Complement Altern Med 2011;2011. [DOI:10.1093/ecam/nep029] [PMID] [PMCID]
25. Hattori N, Nomoto H, Mishima S, Inagaki S, Goto M, Sako M, et al. Identification of AMP N1-oxide in royal jelly as a component neurotrophic toward cultured rat pheochromocytoma PC12 cells. Biosci Biotechnol Biochem 2006;70(4):897-906. [DOI:10.1271/bbb.70.897] [PMID]
26. Ito S, Nitta Y, Fukumitsu H, Soumiya H, Ikeno K, Nakamura T, et al. Antidepressant-like activity of 10-hydroxy-trans-2-decenoic acid, a unique unsaturated fatty acid of royal jelly, in stress-inducible depression-like mouse model. Evidence-Based Complement Altern Med 2012;2012. [DOI:10.1155/2012/139140] [PMID] [PMCID]
27. Ito H, Nakajima A, Nomoto H, Furukawa S. Neurotrophins facilitate neuronal differentiation of cultured neural stem cells via induction of mRNA expression of basic helix‐loop‐helix transcription factors Mash1 and Math1. J Neurosci Res 2003;71(5):648-58. [DOI:10.1002/jnr.10532] [PMID]
28. Gould E, Reeves AJ, Graziano MSA, Gross CG. Neurogenesis in the neocortex of adult primates. Science 1999;286(5439):548-52. [DOI:10.1126/science.286.5439.548] [PMID]
29. Sheline YI. 3D MRI studies of neuroanatomic changes in unipolar major depression: the role of stress and medical comorbidity. Biol Psychiatry 2000;48(8):791-800.
https://doi.org/10.1016/S0006-3223(00)00994-X [DOI:10.1016/s0006-3223(00)00994-x] [PMID]
30. Malberg JE, Eisch AJ, Nestler EJ, Duman RS. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 2000;20(24):9104-10.
https://doi.org/10.1523/JNEUROSCI.20-24-09104.2000 [DOI:10.1523/jneurosci.20-24-09104.2000] [PMID] [PMCID]
31. Duman RS, Heninger GR, Nestler EJ. A molecular and cellular theory of depression. Arch Gen Psychiatry 1997;54(7):597-606. [DOI:10.1001/archpsyc.1997.01830190015002] [PMID]
32. Siuciak JA, Lewis DR, Wiegand SJ, Lindsay RM. Antidepressant-like effect of brain-derived neurotrophic factor (BDNF). Pharmacol Biochem Behav 1997;56(1):131-7.
https://doi.org/10.1016/S0091-3057(96)00169-4 [DOI:10.1016/s0091-3057(96)00169-4] [PMID]
33. Makino A, Iinuma M, Fukumitsu H, Soumiya H, Furukawa Y, Furukawa S. 2-Decenoic acid ethyl ester possesses neurotrophin-like activities to facilitate intracellular signals and increase synapse-specific proteins in neurons cultured from embryonic rat brain. Biomed Res 2010;31(6):379-86. [DOI:10.2220/biomedres.31.379] [PMID]
34. Aslan A, Cemek M, Buyukokuroglu ME, Altunbas K, Bas O, Yurumez Y. Royal jelly can diminish secondary neuronal damage after experimental spinal cord injury in rabbits. Food Chem Toxicol 2012;50(7):2554-9. [DOI:10.1016/j.fct.2012.04.018] [PMID]
35. Mazloom Z, Ekramzadeh M, Hejazi N. Efficacy of supplementary vitamins C and E on anxiety, depression and stress in type 2 diabetic patients: a randomized, single-blind, placebo-controlled trial. Pak J Biol Sci 2013;16(22):1597-600. [DOI:10.3923/pjbs.2013.1597.1600] [PMID]
36. Cocchi P, Silenzi M, Calabri G, Salvi G. Antidepressant effect of vitamin C. Pediatrics 1980;65(4):862-3. [DOI:10.1542/peds.65.4.862] [PMID]
37.
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
