Volume 33, Issue 6 (September 2022)                   Studies in Medical Sciences 2022, 33(6): 458-465 | Back to browse issues page

Ethics code: IR.TBZMED.REC. 1397.642

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URL: http://umj.umsu.ac.ir/article-1-5894-en.html
Assistant professor of gynecology, Maragheh Faculty of Medical Sciences, Maragheh, Iran (Corresponding Author) , dr.shirinfarhoodi@gmail.com
Abstract:   (1233 Views)
Background & Aims: Interventional studies about platelet rich plasma efficacy in the patients with Repeated Implantation Failure (RIF) are not sufficient, while RIF is one of the major limiting factors in treating infertile patients. Therefore, the current study was designed to evaluate whether autologous intrauterine platelet rich plasma (PRP) instillation improves endometrial thickness (ET) in RIF patients during in vitro fertilization-embryo transfer (IVF-ET).
Materials & Methods: In this interventional study, a total of 20 women were enrolled whose embryo transfer cycles were canceled due to lack of proper growth of the endometrium or repeated implantation failure. In the study subjects, PRP was administered intrauterinely, and ultrasound was performed again 72 hours after the injection and the thickness of the endometrium was checked with Doppler ultrasound. Data were analyzed using SPSS 18 software.
Results: The mean ET was calculated 6.80 ± 1.46 mm on the 10th day of menstruation, but 72 hours after the first PRP infusion, the mean ET was 8.09 ± 2 mm. The mean differences of increasing ET was 1.28 ± 0.53 mm (P < 0.02). After 72 hour of infusion, endometrial vascularity was good in 9 patients (45%) and moderate in 11 patients (55%). Two weeks following IVF-ET, β-HCG test was positive in 9 patients (45%) and negative in 11 patients (55%).     
Conclusion: The use of autologous PRP significantly improved the ET and endometrial vascularity, and most importantly increased pregnancy rate and live birth rates in RIF patients.
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Type of Study: Research | Subject: زنان و زایمان

1. Hromadová L, Tokareva I, Veselá K, Trávník P, Veselý J. Endometrial Receptivity Analysis - a tool to increase an implantation rate in assisted reproduction. Ceska Gynekol 2019; 84(3):177-83. [Google Scholar]
2. Chang Y, Li J, Chen Y, Wei L, Yang X, Shi Y, Liang X. Autologous platelet-rich plasma promote endometrial growth and improves pregnancy outcome during in vitro fertilization. Int J Clin Exp Med 2015;8:1286-290. [PMCID]
3. Chin TH, Hsu YC, Soong YK, Lee CL, Wang HS, Huang HY, Wu HM, Yu HT, Huang SY, Chang CL. Obstetric and perinatal outcomes of pregnancy in patients with repeated implantation failure. Taiwan J Obstet Gynecol 2019;58(4):487-91. [DOI:10.1016/j.tjog.2019.05.010] [PMID]
4. Jin HX, Lv AX, Wu ZT, Wen S, Zhang XY, Jin DC, Sun YP. Comparative study on the pregnancy outcomes of in vitro fertilization-embryo transfer between patients with different ovarian responses (a STROBE-compliant article). Medicine (Baltimore) 2019;98(27):e16191. [DOI:10.1097/MD.0000000000016191] [PMID] [PMCID]
5. Kamini AR, Howard C, Robert F. Principles and Practice of assisted reproductive technology, 1st ed.1 vol. chapter 57; 2018: pp:784-809. [Google Scholar]
6. Nazari L, Salehpour S, Hosseini S, Hashemi Moghanjoughi P. Autologous platelet-rich plasma on implantation and pregnancy in repeated implantation failure. Int J Reprod Biomed (Yazd) 2016;10:625-8. [PMID]
7. Molina A, Sánchez J, Sánchez W, Vielma V. Platelet-rich plasma as an adjuvant in the endometrial preparation of patients with refractory endometrium. JBRA Assist Reprod 2018;22(1):42. [DOI:10.5935/1518-0557.20180009] [PMID] [PMCID]
8. Farimani M, Poorolajal J, Rabiee S, Bahmanzade M. Successful pregnancy and live birth after intrauterine administration of autologous platelet-rich plasma in a woman with recurrent implantation failure. Int J Repord Biomed (Yazd) 2017;12:803-6. [DOI:10.29252/ijrm.15.12.803]
9. Hamdi K, Nouri M, Farzaneh S, Mirza-Aghdazadeh-Attari M, Naghavi-Behzad M, Mohammadi S. Effect of Flushing the Endometrial Cavity With Follicular Fluid on Implantation Rates in Sub-Fertile Women Undergoing Invitro Fertilization: A Randomized Clinical trial. J Family Reprod Health 2018;12(4):184-90. [PMCID]
10. Hashish NM, Badway HS, Abdelmoty HI, Mowafy A, Youssef MA. Does flushing the endometrial cavity with follicular fluid after oocyte retrieval affect pregnancyrates in subfertile women undergoing intracytoplasmic sperm injection? Arandomized controlled trial. Eur J Obstet Gynecol Reprod Biol 2014;176:153-7. [DOI:10.1016/j.ejogrb.2014.02.001] [PMID]
11. Eftekhar M, Neghab N, Naghshineh E, Khani P. Can autologous platelet rich plasma expand endometrial thickness and improve pregnancy rate during frozen-thawed embryo transfer cycle? A randomized clinical trial. Taiwan J Obstet Gynecol 2018;57(6):810-3. [DOI:10.1016/j.tjog.2018.10.007] [PMID]
12. Nazari L, Salehpour S, Hosseini MS, Hashemi Moghanjoughi P. The effects of autologous platelet-rich plasma in repeated implantation failure: a randomized controlled trial. Hum Fertil (Camb) 2019;4:1-5. [Google Scholar]
13. Elsokkary M, Eldin AB, Abdelhafez M, Rateb A, Samy M, Eldorf A, Islam BA, et al. The reproducibility of the novel utilization of five-dimensional ultrasound and power Doppler in the prediction of endometrial receptivity in intracytoplasmic sperm-injected women: a pilot prospective clinical study. Arch Gynecol Obstet 2019;299(2):551-8. [DOI:10.1007/s00404-018-5001-4] [PMID]
14. Ozaki Y, Nagao K, Saigo R, Tai T, Tanaka N, Kobayashi H, Nakajima K, Takahashi Y. Sexual Problems among Japanese Women: Data from an Online Helpline. Sexual Med 2015;3(4):295-301. [DOI:10.1002/sm2.83] [PMID] [PMCID]
15. Achache H, Revel A. Endometrial receptivity markers, the journey to successful embryo implantation. Hum Reprod 2006;12(6):731-46. [DOI:10.1093/humupd/dml004] [PMID]
16. Wu PI, Diaz R, Borg-Stein J. Platelet-Rich Plasma. Phys Med Rehabil Clin N Am 2016;27(4):825-53. [DOI:10.1016/j.pmr.2016.06.002] [PMID]
17. El-Anwar MW, Nofal AA, Khalifa M, Quriba AS. Use of autologous platelet-rich plasma in complete cleft palate repair. Laryngoscope 2016;126(7):1524-8. [DOI:10.1002/lary.25868] [PMID]
18. Rossi LA, Molina Romoli AR, Bertona Altieri BA, Burgos Flor JA, Scordo WE, Elizondo CM. Does platelet-rich plasma decrease time to return to sports in acute muscle tear? A randomized controlled trial. J ESSKA 2017;25(10):3319-25. [DOI:10.1007/s00167-016-4129-7] [PMID]
19. Tandulwadkar SR, Naralkar MV, Surana AD, Selvakarthick M, Kharat AH. Autologous intrauterine platelet-rich plasma instillation for suboptimal endometrium in frozen embryo transfer cycles: A pilot study. J Hum Reprod Sci 2017;10(3):208-12. [DOI:10.4103/jhrs.JHRS_28_17] [PMID] [PMCID]
20. Chang Y, Li J, Wei LN, Pang J, Chen J, Liang X. Autologous platelet-rich plasma infusion improves clinical pregnancy rate in frozen embryo transfer cycles for women with thin endometrium. Medicine (Baltimore) 2019;98(3):e14062. [DOI:10.1097/MD.0000000000014062] [PMID] [PMCID]
21. Coksuer H, Akdemir Y, Ulas Barut M. Improved in vitro fertilization success and pregnancy outcome with autologous platelet-rich plasma treatment in unexplained infertility patients that had repeated implantation failure history. Gynecol Endocrinol 2019;35(9):815-8 [DOI:10.1080/09513590.2019.1597344] [PMID]
22. Kim H, Shin JE, Koo HS, Kwon H, Choi DH, Kim JH. Effect of Autologous Platelet-Rich Plasma Treatment on Refractory Thin Endometrium During the Frozen Embryo Transfer Cycle: A Pilot Study. Front Endocrinol (Lausanne) 2019;10:61. [DOI:10.3389/fendo.2019.00061] [PMID] [PMCID]

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