Volume 34, Issue 11 (12-2023)
Studies in Medical Sciences 2023, 34(11): 700-709 |
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Research code: مصوبه 2010-94 دانشگاه آزاد واحد شهررضا
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Amir Sardari K, javadi I, khorrami A. INVESTIGATING THE EFFECT OF COENZYME Q10 ON INFERTILITY CAUSED BY ALUMINUM CHLORIDE IN MALE RATS. Studies in Medical Sciences 2023; 34 (11) :700-709
URL: http://umj.umsu.ac.ir/article-1-6133-en.html
URL: http://umj.umsu.ac.ir/article-1-6133-en.html
Assistant Professor, Medicinal plants Research Center, Maragheh University of Medical Sciences, Maragheh, Iran , arash.khorrami@yahoo.com
Abstract: (1365 Views)
Background & Aims: Male infertility is a common problem among couples, which is partly caused by environmental pollution. Aluminum is one of these pollutants with the property of increasing free radicals. Coenzyme Q10 inhibits oxidative damage through its antioxidant function. In this study, the supportive role of this coenzyme in sperm production disorder caused by aluminum chloride is studied.
Materials & Methods: In this interventional study, 35 male Wistar rats were selected and randomly divided into 5 groups of seven as a control group, a group receiving coenzyme Q10, a group receiving aluminum and two groups treated with coenzyme Q10 with doses of 10 and 20 mg/kg are divided. After that, different sperm factors, the amount of sex hormones, the amount of fatty acid peroxidation, and the antioxidant capacity of the serum are studied and compared with the group receiving aluminum. SPSS program v.20 was used for data analysis. ANOVA and Tukey statistical methods were used to analyze the tests. All data are expressed with a significance level of 5%.
Results: In the rats receiving aluminum, sperms characteristics decreased and the amount of abnormal sperm increased. Sex hormones become out of balance, malondialdehyde level in serum and homogenized testicular tissue increased, and antioxidant capacity decreased. This study showed that coenzyme Q10, especially with a dose of 20 mg/kg, can improve sperm parameters, reduce the amount of malondialdehyde, and maintain hormonal balance.
Conclusion: Coenzyme Q10 can be a suitable supplementary treatment in the management of infertility caused by aluminum chloride toxicity and plays a significant role in reducing its damage.
Materials & Methods: In this interventional study, 35 male Wistar rats were selected and randomly divided into 5 groups of seven as a control group, a group receiving coenzyme Q10, a group receiving aluminum and two groups treated with coenzyme Q10 with doses of 10 and 20 mg/kg are divided. After that, different sperm factors, the amount of sex hormones, the amount of fatty acid peroxidation, and the antioxidant capacity of the serum are studied and compared with the group receiving aluminum. SPSS program v.20 was used for data analysis. ANOVA and Tukey statistical methods were used to analyze the tests. All data are expressed with a significance level of 5%.
Results: In the rats receiving aluminum, sperms characteristics decreased and the amount of abnormal sperm increased. Sex hormones become out of balance, malondialdehyde level in serum and homogenized testicular tissue increased, and antioxidant capacity decreased. This study showed that coenzyme Q10, especially with a dose of 20 mg/kg, can improve sperm parameters, reduce the amount of malondialdehyde, and maintain hormonal balance.
Conclusion: Coenzyme Q10 can be a suitable supplementary treatment in the management of infertility caused by aluminum chloride toxicity and plays a significant role in reducing its damage.
Type of Study: Research |
Subject:
فارماکولوژی
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