دوره 35، شماره 12 - ( 10-1403 )
جلد 35 شماره 12 صفحات 975-961 |
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Mohammadi T. TELOCYTES, THE ENIGMATIC CELLS OF TISSUE: A NARRATIVE REVIEW. Studies in Medical Sciences 2024; 35 (12) :961-975
URL: http://umj.umsu.ac.ir/article-1-6394-fa.html
URL: http://umj.umsu.ac.ir/article-1-6394-fa.html
محمدی طیبه. تلوسیت‌ها، سلول‌های مرموز بافت‌ها: یک مرور روایی. مجله مطالعات علوم پزشکی. 1403; 35 (12) :961-975
استادیار، گروه علوم پایه و پاتوبیولوژی، دانشکده دامپزشکی، دانشگاه رازی، کرمانشاه (نویسنده مسئول) ، tymhd@razi.ac.ir
چکیده: (338 مشاهده)
تلوسیت‌ها سلول‌هایی جدید با منشأ مزانشیمی هستند که دارای یک جسم سلولی کوچک و زوائد طویل و منحصربه‌فردی به نام تلوپود هستند و در بسیاری از بافت‌های بدن یافت می‌شوند. تلوپودها از طریق ترشح وزیکول‌های خارج سلولی یا تماس مستقیم، ارتباط با سلول‌های دوردست را تسهیل می‌کنند. این سلول‌ها نقش مهمی در حفظ هومئوستاز بافت، پاسخ ایمنی، ترمیم بافت و تنظیم عملکرد دیگر سلول‌های بدن ایفا می‌کنند. تلوسیت‌ها معمولاً نشانگرهایی مانند CD34، PDGFRα، c-kit و ویمنتین را بیان می‌کنند، اما فقدان نشانگرهای اختصاصی همچنان یک چالش است. اهمیت مطالعه این سلول‌ها از چند جهت حائز اهمیت است. ازیک‌طرف، شناخت نقش تلوسیت‌ها در بیماری‌های مختلف می‌تواند به توسعه درمان‌های جدید کمک کند و شناسایی گیرنده‌ها و مولکول‌های سیگنالینگ خاص تلوسیت‌ها می‌تواند منجر به توسعه داروهای جدید برای درمان بیماری‌ها شود. از طرف دیگر، تلوسیت‌ها به دلیل نقششان در ترمیم بافت، پتانسیل بالایی برای استفاده در پزشکی بازساختی و درمان بیماری‌ها دارند. بااین‌حال، هنوز چالش‌هایی در شناسایی و عملکرد دقیق تلوسیت‌ها در بافت‌های مختلف وجود دارد. تنوع عملکردی تلوسیت‌ها در بافت‌های مختلف، مطالعه آن‌ها را پیچیده می‌کند و مکانیسم‌های مولکولی دقیق عملکرد تلوسیت‌ها هنوز به‌طور کامل شناخته نشده است. تلوسیت‌ها به‌عنوان یک حوزه تحقیقاتی جدید و جذاب، پتانسیل بالایی برای افزایش درک ما از فیزیولوژی بافت و بیماری‌ها دارند.
نوع مطالعه: مروری |
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بافت شناسی
فهرست منابع
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