Volume 33, Issue 6 (September 2022)
Studies in Medical Sciences 2022, 33(6): 413-425 |
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Esmailbegi Kermani S, Ahmadi M. A REVIEW OF TRADITIONAL USES, PHYTOCHEMISTY AND PHARMACOLOGY OF CAPPARIS DECIDUA (FORSSK.) EDGEW: AN UNKNOWN MEDICINAL PLANT IN IRAN. Studies in Medical Sciences 2022; 33 (6) :413-425
URL: http://umj.umsu.ac.ir/article-1-5833-en.html
URL: http://umj.umsu.ac.ir/article-1-5833-en.html
Assistant Professor, Department of Biology, School of Science, Urmia University, Urmia, Iran , sh.esmailbegi@urmia.ac.ir
Abstract: (3678 Views)
Background & Aims: Capparis decidua (Kair) is an important economic plant belonging to the family of Capparaceae. This plant is mainly found in desert areas, and is resistant to temperature, salinity, and drought stresses. This species is valuable for medicinal purposes, food (fruits and pickles), providing animal fodder, fuel wood, and timber. C. decidua is traditionally used as anti-inflammatory, anti-rheumatic, anti-diabetic, anti-worm, anti-bacterial, anti-acne and blister, toothache relief, anti-fertility, and as an appetizer. It also has beneficial effects in the treatment of various diseases such as asthma, diabetes, liver disorders, blood cholesterol, high blood pressure and microbial infections. The present review introduces the traditional uses, herbal chemical compounds, and medicinal properties of this widely used plant.
Materials & Methods: The present study is a review article that was conducted by an electronic search in Civilica, SID, Springer, PubMed, Science Direct, and Willy.
Results: These medicinal properties are due to the presence of herbal compounds such as alkaloids, phenols, flavonoids, sterols, vitamins and fatty acids in the extract of different parts of Kair. In spite of its medicinal value, C. decidua has been neglected in both traditional medicine and scientific research in Iran.
Conclusion: A review of the studies conducted in Iran shows that the medicinal value of C. decidua in Iran has been neglected both in traditional medicine and in scientific research, and the present research can provide information to those interested in the field of medicinal plants. It can also provide the basis for further studies on this valuable plant.
Materials & Methods: The present study is a review article that was conducted by an electronic search in Civilica, SID, Springer, PubMed, Science Direct, and Willy.
Results: These medicinal properties are due to the presence of herbal compounds such as alkaloids, phenols, flavonoids, sterols, vitamins and fatty acids in the extract of different parts of Kair. In spite of its medicinal value, C. decidua has been neglected in both traditional medicine and scientific research in Iran.
Conclusion: A review of the studies conducted in Iran shows that the medicinal value of C. decidua in Iran has been neglected both in traditional medicine and in scientific research, and the present research can provide information to those interested in the field of medicinal plants. It can also provide the basis for further studies on this valuable plant.
Type of Study: Review article |
Subject:
General
References
1. Jameel S, Ahmad S, Akram M., Zainab R., Sharif A. Antifungal activity in the methanolic, aqueous and hexane extracts of Capparis decidua. Eur J Inflamm 2018;16: 2058739218781701. [DOI:10.1177/2058739218781701]
2. Zhang H, Ma ZF. Phytochemical and pharmacological properties of Capparis spinosa as a medicinal plant. Nutrients 2018;10(2): 1-14. [DOI:10.3390/nu10020116] [PMID] [PMCID]
3. Hall JC. Systematics of Capparaceae and Cleomaceae: an evaluation of the generic delimitations of Capparis and Cleome using plastid DNA sequence data. Botany 2008; 86(7): 682-96. [DOI:10.1139/B08-026]
4. Cornejo X, Iltis HH. Two New Genera of Capparaceae: Sarcotoxicum and Mesocapparis stat. nov., and the Reinstatement of Neocalyptrocalyx. Harvard Pap Bot 2008;13(1): 103-16.
https://doi.org/10.3100/1043-4534(2008)13[103:TNGOCS]2.0.CO;2 [DOI:10.3100/025.015.0101]
5. Mahla HR, Rathore VS, Singh D, Singh JP. Capparis decidua (Forsk.) Edgew.: an underutilized multipurpose shrub of hot arid region-distribution, diversity and utilization. Genet Resour Crop Evol 2013;60(1): 385-94. [DOI:10.1007/s10722-012-9934-3]
6. Singh P, Mishra G, Srivastava S, Jha KK, Khosa RL. Traditional uses, phytochemistry and pharmacological properties of capparis decidua: An overview. Der Pharm Lett 2011;3(2): 71-82. [URL]
7. Zia-Ul-Haq M., Ćavar S, Qayum M, Imran I, de Feo V. Compositional studies: antioxidant and antidiabetic activities of Capparis decidua (Forsk.) Edgew. Int J Mol Sci 2011;12(12): 8846-8861. [DOI:10.3390/ijms12128846] [PMID] [PMCID]
8. Verma PD, Dangar RD, Shah KN, Gandhi DM, Suhagia, BN. Pharmacognostical Potential of capparis decidua Edgew. J Appl Pharm Sci 2011;1(10): 06-11. [Google Scholar]
9. Nazar S, Hussain MA, Khan A, Muhammad G, Tahir MN. Capparis decidua Edgew (Forssk.): A comprehensive review of its traditional uses, phytochemistry, pharmacology and nutrapharmaceutical potential. Arab J Chem 2020; 13(1): 1901-16. [DOI:10.1016/j.arabjc.2018.02.007]
10. Rathee S, Rathee P, Rathee D, Rathee D, KumarV. Phytochemical and pharmacological potential of kair (Capparis decidua). Int J Phytomedicine 2010;2(1): 10-17. [Google Scholar]
11. Anjum S, Asif M, Zia K, Jahan B, Ashraf M, Hussain S et al. Biological and phytochemical studies on Capparis decidua (Forssk) Edgew from Cholistan desert. Nat Prod Res 2020; 34(16): 2315-8. [DOI:10.1080/14786419.2018.1531403] [PMID]
12. Dhakad PK, Sharma PK, Kumar S. Effect of hydroalcoholic extract of capparis decidua (forssk.) edgew on sexual behavior of male rats. Adv Pharmacol Pharmacy 2018;6(2): 50-6. [DOI:10.13189/app.2018.060203]
13. Ayat AA, Sayadat ET, Sakina Y. Biological activity of extracts from Capparis decidua L. twigs. J Med Plant Res 2016;10(1): 1-7. [DOI:10.5897/JMPR2015.5994]
14. Sharma B, Salunke R, Balomajumder, C, Daniel S, Roy P. Anti-diabetic potential of alkaloid rich fraction from Capparis decidua on diabetic mice. J Ethnopharmacol 2010;127(2): 457-62. [DOI:10.1016/j.jep.2009.10.013] [PMID]
15. Rathee P, Rathee D, Rathee D, Rathee S. In vitro anticancer activity of stachydrine isolated from Capparis decidua on prostate cancer cell lines. Nat Prod Res 2012;26(18): 1737-40. [DOI:10.1080/14786419.2011.608673] [PMID]
16. Rathee P, Rathee D, Rathee D, Rathee S. In-vitro cytotoxic activity of β-Sitosterol triacontenate isolated from Capparis decidua (Forsk.) Edgew. Asian Pac J Trop Med 2012;5(3): 225-30. [DOI:10.1016/S1995-7645(12)60029-7] [PMID]
17. Mohammed MS, Khalid HS, Muddathir AK, Siddiqui NA, Ali M. A novel germacranolide sesquiterpene lactone with anti-inflammatory effect from Capparis decidua (Forsk.). Int J Pharm Sci Rev Res 2012 2(4): 1073-7. [Google Scholar]
18. Goyal M, Nagori BP, Sasmal D. Sedative and anticonvulsant effects of an alcoholic extract of Capparis decidua. J Nat Med 2009;63(4): 375-9. [DOI:10.1007/s11418-009-0339-3] [PMID]
19. Jhajharia KM, Agarwal SK, Srivastava B. Hepatoprotective activity of Capparis decidua on liver damage caused by thioacetamide in Wistar male rats. Int J Toxicol Pharmacol Res 2010;2: 92-4. [Google Scholar]
20. Zaman SU, Akhtar N, Barkat AK, Ali Khan B, Mahmood T, Rasul T et al. Development of a sebum control cream from a local desert plant Capparis decidua. J Med Plant Res 2012;6(5): 744-8. [DOI:10.5897/JMPR11.1259]
21. Purohit A, Vyas KB. Antiatherosclerotic effect of Caparis decidua. Fruit extract in cholesterol-fed rabbits. Pharm Biol 2006;44(3): 172-7. [DOI:10.1080/13880200600686566]
22. Patil SB, Naikwade NS, Nirwane AM, Magdum CS, Bendgude RD, Jadhav SY. Laxative activity of Capparis decidua Edgew stem bark in wistar albino rats. Nov Sci Int J Pharmaceu Sci 2012;1(6): 327-8. [URL]
23. Sarathchandiran I, Manavalan R, Akbarsha MA, Kadalmani B, Karar PK. Studies on spermatotoxic effect of ethanolic extract of Capparis aphylla (Roth). J Biol Sci 2007;7(3): 544-8. [DOI:10.3923/jbs.2007.544.548]
24. Kunwar B, Jain V, Verma SK. Qualitative phytochemical screening and in vitro thrombolytic activity of Capparis decidua Edgew. Fruit. GSC Biol Pharmaceu Sci 2022;19(3): 160-7. [DOI:10.30574/gscbps.2022.19.3.0232]
25. Khan S, Ansari I. Antiparkinsonian activity of hydroalcoholic extract of the stems of Capparis decidua (Forssk.) Edgew. Int J Pharm Sci Rev Res 2021; 12(10): 5388-5395. [URL]
26. Farhan Rasheed HM, Jabeen Q. Pharmacological role of Capparis decidua (Forssk.) Edgew in preventing cyclophosphamide-induced myelosuppression and modulating innate and adaptive immune response. Dose Response 2022;20(3): 15593258221123672. [DOI:10.1177/15593258221123672] [PMID] [PMCID]
27. Ahmadi M, Saeidi S, Mirtadzadini M. Biosystematic stady of the genus Capparis in Iran [dissertation]. Isfahan Univ; 2020.
28. Saghafi Khadem F. Flora of Iran. Capparaceae. Number 30. Research Institute of Forests and Rangelands, Tehran; 2000.
29. Chishty S, Monika. Medicinal and nutritional importance of C. decidua (Forssk.) Edgew. (Capparaceae): a review. Int J Sci Res 2016;5(2): 141-7. [DOI:10.21275/v5i2.NOV161064]
30. Singh D, Singh RK. Kair (Capparis decidua): A potential ethnobotanical weather predictor and livelihood security shrub of the arid zone of Rajasthan and Gujarat. Indian J Tradit Knowl 2011;10(1): 146-55. [URL]
31. Ahmad VU, Ismail N, Arif S, Amber, AUR. Two new N-acetylated spermidine alkaloids from Capparis decidua. J Nat Prod 1992;55(10): 1509-12. [DOI:10.1021/np50088a018]
32. Gupta J, Ali M. Oxygenated heterocyclic constituents from Capparis decidua root-barks. Indian J Heterocycl Chem 1997;6(4): 295-302.
33. Nour AM, El-imam YMA. Phytochemical and antimicrobial screening of Capparis decidua stems. Sudan Med Monit 2013; 8(3): 140-5. [DOI:10.4103/1858-5000.132602]
34. Wazir MA, Azhar MI, Mehmood ZA, Qadir MI, Khan MY, Siddique FA et al. Pharmacognostic, phytochemical, biological and spectroscopic analyses of Capparis decidua (Forsk.) Edgew root and stem bark. Trop J Pharm Res 2020;19(12): 2667-75. [DOI:10.4314/tjpr.v19i12.27]
35. Mann S, Chaudhary I, Gupta RK. Value addition scenario of arid foods of desert area and evaluation of their nutritional and phytochemical potential. Int J Pharm Life Sci 2013;4(1): 2335-9. [Google Scholar]
36. Neeraj NV, Jangir SSBL. Quality assessment and phytochemical profile of Capparis decidua (Forssk) Edgew. Pharma Innovation 2019;8(2): 424-30. [Google Scholar]
37. Mishra SN, Tomar PC, Lakra N. Medicinal and food value of Capparis-a harsh terrain plant. Indian J Tradit Knowl 2007;6(1): 230-8. [Google Scholar]
38. Devki GS, Sisodia, R. Screening of the Potential Phytochemicals from the Capparis decidua Fruit Extract using GC-MS. Open Acc J Bio Sci 2020; 2(6): 722-6. [DOI:10.38125/OAJBS.000235]
39. Bhagat S, Rathore M, Kachhwaha S, Sharma HK. Phytochemical screening, determination of total phenol content, total flavonoid content and quantitative estimation of rutin and quercetin using RP-HPLC in the fruits of Capparis decidua (Forsk.) Edgew. Ind J Pure app Ind J Pure app Biosci 2021;9: 254-61. [DOI:10.18782/2582-2845.8666]
40. Duhan A, Chauhan BM, Punia D. Nutritional value of some non-conventional plant foods of India. Plant Foods Hum Nutr 1992;42(3): 193-200. [DOI:10.1007/BF02193926] [PMID]
41. Gull T, Sultana B, Bhatti, IA, Jamil, A. Antibacterial potential of Capparis spinosa and Capparis decidua extracts Int J Agric Biol 2015;17(4): 727-33. [DOI:10.17957/IJAB/14.0007]
42. Tripathi YC, Singh S, Anjum N, Srivastava KK. Antifungal activity of Capparis decidua extracts against seed-borne pathogenic fungi. World J. Pharma Pharma Sci 2015;4(10): 1500-12. [Google Scholar]
43. Yadav P, Sarkar S, Bhatnagar D. Action Of Capparis decidua against Alloxan-induced oxidative stress and diabetes in rat tissues. Pharmacol Res 1997;36(3): 221-8. [DOI:10.1006/phrs.1997.0222] [PMID]
44. Ramzani Ghara A, Ezzati Ghadi F, Hosseini SH, Piacente S, Cerulli A, Alizadeh A, Mirmahmoudi R. Antioxidant and antidiabetic effect of capparis decidua edgew (Forssk.) extract on liver and pancreas of streptozotocin-induced diabetic rats. J App Biol Res 2021;8(1). [Google Scholar]
45. Rathee S, Mogla OP, Sardana S, Vats M., Rathee P. Antidiabetic activity of Capparis decidua Forsk Edgew. J Pharm Res 2010;3: 231-4. [Google Scholar]
46. Devki RV, Sisodia R. Chemopreventive potential of capparis decidua fruit extract against dmba induced skin carcinogenesis in swiss albino mice. Int J Pharm Sci 2020;11(12): 6189-97. [URL]
47. Ageel AM, Parmar NS, Mossa JS, Al-Yahya MA, Al-Said MS, Tariq M. Anti-inflammatory activity of some Saudi Arabian medicinal plants. Agents Actions 1986;17(3): 383-4. [DOI:10.1007/BF01982656] [PMID]
48. Verma PD, Dangar RD, Suhagia, BN. Evaluation of anti-inflammatory activity of Capparis decidua Edgew. stem. Int J Pavement Res Technol 2013;3(2): 16-9. [Google Scholar]
49. Dahiya R, Vaghela JS. Evalution of anti-asthmatic activity of Capparis decidua. Asian J Pharm Clin Res 2022;15(2): 94-7. [DOI:10.22159/ajpcr.2022.v15i2.43378]
50. Farzaei MH, Farzaei F, Abdollahi M, Abbasabadi Z, Abdolghaffari AH, Mehraban B. A mechanistic review on medicinal plants used for rheumatoid arthritis in traditional Persian medicine. J Pharm Pharmacol 2016;68(10): 1233-48. [DOI:10.1111/jphp.12606] [PMID]
51. Dhakad PK, Sharma PK, Kumar S. Evaluation of Anti-arthritic Activity of Hydroalcoholic Extract of Capparis decidua (Forssk.) Edgew. on Freund's Complete Adjuvant-induced Arthritis in Rats. Imm Infec Dis 2018;6(1): 6-15. [DOI:10.13189/iid.2018.060102]
52. Kumar DS, Shukla A, Choudhury PK, Singh GK. Analgesic and anti-nociceptive activity of hydroethanolic extract of Capparis decidua Linn. Asian J Pharm Pharmacol 2015;1(1): 40-4. [URL]
53. Rehman J, Akhtar N, Asif HM, Sultana S, Ahmad M. Hepatoprotective evaluation of aqueous-ethanolic extract of Capparis decidua (stems) in paracetamol induced hepatotoxicity in experimental rabbits. Pak J Pharm Sci 2017;30(2): 507-11. [Google Scholar]
54. Ali SA, Al-Amin TH, Mohamed AH, Gameel AA. Hepatoprotective activity of aqueous and methanolic extracts of Capparis decidua stems against carbon tetrachloride induced liver damage in rats. J Pharmacol Toxicol 2009;4(4): 167-72. [DOI:10.3923/jpt.2009.167.172]
55. Ali SA, Gameel AA, Mohamed AH, Hassan T. Hepatoprotective activity of Capparis decidua aqueous and methanolic stems extracts against carbon tetrachloride induced liver histological damage in rats. J Pharmacol Toxicol 2011;6(1): 62-8. [DOI:10.3923/jpt.2011.62.68]
56. Mohamed M, Hassan SK, Mona SM, Ahmed BM, Amna A, Wadah O et al. Hepatoprotective and free radical scavenging activities of methanol extract fractions of Capparis decidua Edgew (Forssk.) (Capparidaceae). Afr J Pharm Pharmacol 2020;14(8): 316-30. [URL]
57. Santhakumar P, Roy A, Ganesh MK, Selvaraj J, Prathap L, Babu KY. Ethanolic extract of Capparis decidua fruit ameliorates methotrexate-induced hepatotoxicity by suppressing oxidative stress and inflammation by modulating nuclear factor-kappa B signaling pathway. Pharmacogn Mag 2021;17(6): 143-50. [DOI:10.4103/pm.pm_402_20]
58. Chahlia N. Evaluation of hypolipidaemic activity of Capparis decidua. Int J Biomed Sci 2009;5(1): 70-3. [PMCID]
59. Shahraki MR, Badini F, Shahraki E, Shahraki AR, Dashipour A. Effects of Capparis decidua hydroalcoholic extracts on blood glucose, lipid profile and leptin of Wistar male rats with high cholesterol diets. Nutr Food Sci 2020;7(1): 25-31 [DOI:10.29252/nfsr.7.1.25]
60. Shah AJ, Gilani AH. Blood pressure lowering effect of the extract of aerial parts of Capparis aphylla is mediated through endothelium-dependent and independent mechanisms. Clin Exp Hypertens 2011;33(7): 470-7. [DOI:10.3109/10641963.2010.549273] [PMID]
61. Ali MZ, Mehmood MH, Saleem M., Akash MSH, Malik A. Pharmacological evaluation of Euphorbia hirta, Fagonia indica and Capparis decidua in hypertension through in-vivo and in vitro-assays. Heliyon 2021;7(10): e08094. [DOI:10.1016/j.heliyon.2021.e08094] [PMID] [PMCID]
62. Mohammed MS, Khalid HS, Muddathir AK, El Tahir KE, Osman B, Osman WJ. Effect of two sesquiterpene lactones from Capparis decidua (Forsk.) on arachidonic acid and adenosine diphosphate-induced platelets aggregation. J Phytopharmacol 2014;3(3): 176-9. [DOI:10.31254/phyto.2014.3304]
63. Ali MZ, Mehmood MH, Haneef M, Saleem M, Ishrat G, Siddiqi HS et al. A flavonoid driven phyto-pharmacological effects of capparis decidua Edgew. in rodents. Pak J Pharm Sci 2020;33: 333-42. [Google Scholar]
64. Logue CM, Barbieri NL, Nielsen DW. Pathogens of food animals: Sources, characteristics, human risk, and methods of detection. Adv Food Nutr Res 2017;82: 277-365. [DOI:10.1016/bs.afnr.2016.12.009] [PMID]
65. Sumaia, AA, Mohammed GE, Gameel AA. In vitro Adulticidal Efficacy of Albendazole, capparis decidua stems and Moringa oleifera leaves against Fasciola gigantic. J Sudan Univ Sci Tech 2012;13(2): 59-67. [URL]
66. Revathi P, Vani B, Sarathchandiran I, Kadalmani B, Shyam KP, Palnivel K. Reproductive toxicity of Capparis aphylla (Roth.) in male albino rats. Int J Pharm Biomed Res 2010;1(3): 102-12. [Google Scholar]
67. Dhakad PK, Sharma PK, Silaev SK. Effect of hydroalcoholic extract of capparis decidua (Forssk.) Edgew on serum testosterone and spermatogenesis in rats. Eur Chem Bull 2017;6(12): 554-7. [DOI:10.17628/ecb.2017.6.554-557]
68. Joseph B, Jini D. A medicinal potency of Capparis decidua- a harsh terrain plant. Res J Phytochem 2011;5(1): 1-13. [DOI:10.3923/rjphyto.2011.1.13]
69. Shad AA, Ahmad S, Ullah R, AbdEl-Salam NM, Fouad H, Rehman et al. Phytochemical and biological activities of four wild medicinal plants. Sci World J 2014; 1-7. [DOI:10.1155/2014/857363] [PMID] [PMCID]
70. Satyanarayana T, Anjana A, Vijetha P. PHCOG REV.: plant review phytochemical and pharmacological review of some Indian Capparis species. Phcog Rev 2008; 2(4): 36-45. [Google Scholar]
71. Damizadeh GR. Copertree (Capparis decidua); unknown fruit of south Iran. Iran J Forest Poplar Res 2004;12(1): 1-12. [Google Scholar]
72. Chaturvedi Y, Nagar R. Levels of β-carotene and effects of processing on selected fruits and vegetables of the arid zone of India. Plant Foods Hum Nutr 2001;56(2): 127-32. [DOI:10.1023/A:1011174400658] [PMID]
73. Kumar S, Sharma R, Kumar V, Vyas GK, Rathore A. Combining molecular-marker and chemical analysis of capparis decidua (Capparaceae) in the Thar Desert of Western Rajasthan (India). Rev Biol Trop 2013;61(1): 311-20. [DOI:10.15517/rbt.v61i1.11130] [PMID]
74. Iqbal A, Anwar F, Nadeem R., Sultana B, Mushtaq M. Proximate composition and minerals profile of fruit and flower of Karir (capparis decidua) from Different regions of Punjab (Pakistan). Asian J Chem 2014;26(2): 360-4. [DOI:10.14233/ajchem.2014.15394]
75. Gull T, Mahmood Z, Anwar F, Sultana B, Nouman W, Shahid SA et al. Variation of proximate composition and minerals within different parts of Capparis decidua (Forssk.) Edgew. as a function of harvesting seasons. Pak J Bot 2015;47(5): 1743-8. [Google Scholar]
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