Background & Aims: It has been proposed that uric acid (UA) and FetuinA (FA) are independent risk factor for the development of cardiovascular disease (CAD). UA is the end-product of purine metabolism and is considered an endogenous antioxidant. FA is a protein secreted by the liver acting as an inhibitor of coronary artery calcification. The aim of the present investigation was to survey the association between severity of CAD and sera UA or FA.

Materials & Methods: Subjects (n=83) undergoing coronary angiography were enrolled. According to angiographic results, the subjects were divided into: Control (CTL n=21 age 55±8.9 years), one vessel obstruction (1VD n=20 57±10.1 years) and multi-vessel obstruction (Multi VD n=42 65.4±9.7 years). FA level were determined by ELISA. Clinical biochemical parameters were assayed by routine laboratory methods. Statistical analyses were performed using SPSS package (version 22).

Results: Serum UA levels in multi VD and 1VD were higher than that of CTL group (P=0.05). FA levels slightly declined with the severity of CAD (P=0.23). Multi-regression analysis revealed that age, BMI, HDL-C, glucose and Hb were associated with the severity of CAD. It was also found that UA is independent for the prevalence of CAD.

Conclusions: Considering the small sampling size, this study demonstrates that increasing UA levels is associated with the severity of CAD and is an independent risk factor for the occurrence of CAD. Regarding the impact of FA on the severity of CAD, further studies with larger sample size and the implementation of a scoring system for degree of artery calcification are deemed necessary.

SOURCE: URMIA MED J 2015: 26(8): 671 ISSN: 1027-3727