Volume 25, Issue 11 (Monthly-Jan 2015)                   J Urmia Univ Med Sci 2015, 25(11): 998-1004 | Back to browse issues page

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Bonyadi M, Mohammadian T, Rafeey M, Sadeghi Shabestari M, Mortazavi F. ASSOCIATION OF CHEMOKINE CCL2 GENE POLYMORPHISM WITH HENOCHE SCHONLEIN PURPURA DISEASE IN NORTH-WEST OF IRAN. J Urmia Univ Med Sci. 2015; 25 (11) :998-1004
URL: http://umj.umsu.ac.ir/article-1-2607-en.html
Center of Excellence for Biodiversity, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran / Pediatric Health Research Center, Tabriz University of Medical Sciences , jabbarpour@tabrizu.ac.ir
Abstract:   (6359 Views)


  Background & Aims : Henoch–Schönlein purpura (HSP) is an autoinflammatory disease and systemic small vessel vasculitis that more frequently occurs in children. It is characterized by skin lesion such as Petechia and purpura, gasterointestinal involvement including abdominal pain and gastrointestinal bleeding and arthiritis. Studies have shown that HSP could be due to different infections and genetic factors. Based on the fact that cytokines have important role in this inflammatory disease, CCL2- a chemokine encoding gene- is studied in HSP patients from northwestern Iran. To achieve this goal molecular analysis of polymorphism located in promoter region of this gene is performed.

  Materials & Methods : This study was conducted on 40 HSP patients who were referred by immunology and allergy specialists to Genetic Center of Tabriz and after blood sampling and DNA extraction, molecular analysis with PCR-RFLP method was performed to genotype polymorphic region of promoter region of this gene. The results were compared to that of 50 ethnic-sex matched control healthy people.

  Results : Statistical analysis shows significant association of this polymorphism with development of Henoch–Schönlein purpura disease in this cohort. The frequency of TT and TC genotypes and T allele of CCL2 -C2518T gene polymorphism were significantly higher in HSP patients.

  Conclusion : CCL2 C-2518T gene polymorphisms were associated with susceptibility to HSP in Northwestern Iran.


 SOURCE: URMIA MED J 2015: 25(11): 1004 ISSN: 1027-3727

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Type of Study: Research | Subject: آناتومی

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