Background & Aims: Preeclampsia complicates 5 to 10 percent of all pregnancies that contribute greatly to maternal morbidity and mortality rates. Although homocysteine is a necessary amino acid to maintain cell growing and developing but at the serum levels above normal is a risk factor for some endothelial damages and thrombosis inside blood vessels. In the present study, we investigated the relationship among with serum levels of homocysteine, folic acid, and vitamin B12 and the risk of sever preeclampsia in normal pregnant women suffering from it. The aim of this study was introducing a way to prevent sever preeclampsia.

Materials & Methods: This study was carried out at Shahid Motahari Hospital (Urmia University of Medical Sciences) on 2010. This study was a case-control prospective one. Serum samples of 35 preeclamptic patients and 35 women with normal pregnancy at their third three-month period were collected and their plasma samples were separated and then frozen till assayed. Serum levels of homocysteine, folic acid, and vitamin B12 were then measured on melted plasma samples, and then the results were compared between the two groups. Statistical analysis was carried out by SPSS program and T-Test, and proportional risk as well as confidence distance was also calculated.

Results: In the pregnant women suffering from severe preeclampsia, the concentration of homocysteine was higher but the concentration of folic acid and vitamin B12 were lower than the control group. (P < 0.05)

Conclusion: In our study, the third semester hyper-hemosysteinemia and lower blood levels of folic acid and vitamin B12 were related to sever preeclampsia, which demonstrates their role in pathological process/progress of the condition. Therefore, we suggest testing their blood levels in early diagnosis of preeclampsia.