Volume 35, Issue 3 (June 2024)
Studies in Medical Sciences 2024, 35(3): 218-231 |
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Hashemi V, Hosseini A. THE ROLE AND FUNCTION OF REGULATORY T CELLS (TREGS) IN PREGNANCY AND PREECLAMPSIA: A NARRATIVE REVIEW. Studies in Medical Sciences 2024; 35 (3) :218-231
URL: http://umj.umsu.ac.ir/article-1-6242-en.html
URL: http://umj.umsu.ac.ir/article-1-6242-en.html
Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran (Corresponding Author) , hosseiniare@yahoo.com
Abstract: (750 Views)
Background & Aims: Preeclampsia (PE) is a pregnancy-specific syndrome recognized as a major risk factor for preterm delivery. Preeclampsia (PE) is characterized by high blood pressure, significant proteinuria, and an excessive maternal systemic inflammatory response. The aim of this study was to investigate the role and function of regulatory T cells (Tregs) in pregnancy and preeclampsia.
Materials & Methods: This study is a narrative review that utilized the PubMed-Medline and Embase databases to search for the role of regulatory T cells (Tregs) in pregnancy and preeclampsia. Data were obtained from searching and extracting relevant articles.
Results: The results of various studies indicated that paternal antigens and female sex hormones are responsible for the increased number of Tregs during pregnancy. The expansion of Tregs and the regulation of the immune system are essential for maternal tolerance towards the fetus. Indeed, the number and function of Tregs play a crucial role in pregnancy; a reduction in the number and function of these cells is observed in unsuccessful pregnancies such as those complicated by preeclampsia.
Conclusion: Regulatory T cells play vital roles in maintaining immune tolerance towards the fetus during pregnancy. A decrease in the number or function of these cells can lead to pregnancy complications, including preeclampsia. Health professionals should be aware of the importance of immune balance during pregnancy and consider immune system-related factors when assessing the risk of preeclampsia. Additionally, a better understanding of the role of Tregs could contribute to the development of new diagnostic and therapeutic methods for preeclampsia.
Materials & Methods: This study is a narrative review that utilized the PubMed-Medline and Embase databases to search for the role of regulatory T cells (Tregs) in pregnancy and preeclampsia. Data were obtained from searching and extracting relevant articles.
Results: The results of various studies indicated that paternal antigens and female sex hormones are responsible for the increased number of Tregs during pregnancy. The expansion of Tregs and the regulation of the immune system are essential for maternal tolerance towards the fetus. Indeed, the number and function of Tregs play a crucial role in pregnancy; a reduction in the number and function of these cells is observed in unsuccessful pregnancies such as those complicated by preeclampsia.
Conclusion: Regulatory T cells play vital roles in maintaining immune tolerance towards the fetus during pregnancy. A decrease in the number or function of these cells can lead to pregnancy complications, including preeclampsia. Health professionals should be aware of the importance of immune balance during pregnancy and consider immune system-related factors when assessing the risk of preeclampsia. Additionally, a better understanding of the role of Tregs could contribute to the development of new diagnostic and therapeutic methods for preeclampsia.
Type of Study: Review article |
Subject:
ایمونولوژی
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