Volume 36, Issue 1 (4-2025)                   Studies in Medical Sciences 2025, 36(1): 40-48 | Back to browse issues page

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Mahmodlou R, Kazemzadeh J. Rare gastric schwannoma presenting with severe gastrointestinal bleeding: A case report. Studies in Medical Sciences 2025; 36 (1) :40-48
URL: http://umj.umsu.ac.ir/article-1-6405-en.html
Burn and Reconstructive Fellowship and Assistant professor of general surgery, Department of General Surgery, School of Medicine, Urmia University of Medical Sciences, Urmia,Iran (Corresponding author) , drjafarkazemzade48@gmail.com
Abstract:   (138 Views)
Schwannoma, also known asneurilemmoma or neurinoma, is generally a benign, slow-growing neoplasm that originates from any nerve containing a Schwann cell sheath. These neoplasms are rare among spindle cell mesenchymal tumors of the gastrointestinal tract but most commonly occur in the stomach, accounting for 0.2% of gastric tumors. Gastric schwannoma is a rare tumor, and its presentation with severe gastrointestinal bleeding is even rarer. Diagnosing gastric schwannoma with severe gastrointestinal bleeding poses several challenges, as this tumor is uncommon and its symptoms are often mistaken for other gastrointestinal disorders. In this report, we present a case that highlights the importance of differential diagnosis of such lesions when dealing with gastrointestinal bleeding. The patient was amale 44-year-old with a large gastric schwannoma in the distal stomach. The patient was admitted with severe gastrointestinal bleeding, presenting with Hb = 9 and Hct = 25.3. The patient underwent resuscitation, fluid therapy, and received a total of eight units of blood in two sessions.After stabilization; the patient underwent endoscopy, which revealed a large submucosal lesion and an ulcer with blood in the gastric antrum, though no active bleeding site or vessel was identified. The patient subsequently underwent distal gastrectomy with Billroth I reconstruction. Postoperative immunohistochemical staining of the mass was positive for S100, KI67, and SMA but negative for CD34 and CD117. The patient was discharged five days postoperatively in satisfactory condition, and the final pathology report confirmed the diagnosis of gastric schwannoma.
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Type of Study: case report | Subject: جراحی عمومی

References
1. Yoon HY, Kim CB, Lee YH, Kim HG. Gastric Schwannoma. Yonsei Med J 2008;49(6):1052-4. [DOI:10.3349/ymj.2008.49.6.1052] [PMID] []
2. Majdoubi A, El Achchi A, El Hammouti M, Bouhout T, Serji B. Gastric schwannoma: The gastrointestinal tumor simulator-case report and review of the literature. Int J Surg Case Rep 2024;116:109389. [DOI:10.1016/j.ijscr.2024.109389] [PMID] []
3. Fan S, Wang H, Sun X, Gai C, Liang C, Wang G, et al. Comprehensive analysis of diagnosis and treatment in 99 cases of abdominal Schwannoma. Cancer Med 2024;13(16):e70140. [DOI:10.1002/cam4.70140] [PMID] []
4. Shah AS, Rathi PM, Somani VS, Mulani AM. Gastric Schwannoma: A Benign Tumor Often Misdiagnosed as Gastrointestinal Stromal Tumor. Clin Pract 2015;5(3):775-80. [DOI:10.4081/cp.2015.775] [PMID] []
5. Williamson JML, Wadley MS, Shepherd NA, Dwerryhouse S. Gastric schwannoma: a benign tumour often mistaken clinically, radiologically and histopathologically for a gastrointestinal stromal tumour - a case series. Ann R Coll Surg Engl 2012;94(4):245-9. [DOI:10.1308/003588412X13171221590935] [PMID] []
6. Abbasi F, Javanmard F, Esmaiel fam M. Evaluation of the histopathologic characteristics of gastrointestinal tumors in endoscopy samples in urmia imam khomeini hospital. Stud Med Sci 2021;32(7):537-47. [DOI:10.52547/umj.32.7.537]
7. Abbasi F, Benyamin B. Histopathological diagnosis of gastrointestinal biopsy samples with endoscopic finding of erythema: a retrospective study. Stud Med Sci 2019;30(4):322-8. [google scholar]
8. Cruz Centeno N, Suarez Dominguez A, Mojica Mañosa P, Carlo VP. Incidental finding of a gastric schwannoma: a case report. J Surg Case Rep 2021;2021(11):rjab509. [DOI:10.1093/jscr/rjab509] [PMID] []
9. Joukar F, Hosseini Basti RS, Hosseini Basti FS, Mosafer F, Hosseini Basti HS, Hedayatzadeh Z, et al. Assessment of patients with non-variceal upper gastrointestinal bleeding using AIMS65 score. Stud Med Sci 2024;35(1):51-9. [DOI:10.61186/umj.35.1.51]
10. Baig MM, Patel R, Kazem MA, Khan A. Schwannoma in the ascending colon, a rare finding on surveillance colonoscopy. J Surg Case Rep 2019;2019(2):1-4. [DOI:10.1093/jscr/rjz046] [PMID] []
11. Lomdo M, Setti K, Oukabli M, Moujahid M, Bounaim A. Gastric schwannoma: a diagnosis that should be known in 2019. J Surg Case Rep 2020;2020(1):49-53. [DOI:10.1093/jscr/rjz382] [PMID] []
12. Pais DP, Andrade S, Colaco IB, Luis M, Azenha N, Couceiro A, et al. Gastric Schwannoma: A Rare Cause of Gastric Bleeding. J Med Cases 2024;15(12):371-6. [DOI:10.14740/jmc4312] [PMID] []
13. Pohekar M, Rampurwala J, Sabireen, Shinde RS. Gastric Schwannoma-Two Unusual Cases with Usual Presentation and Review of Literature. Indian J Surg Oncol 2024;15(1):117-20. [DOI:10.1007/s13193-023-01847-0] [PMID] []
14. Li J, Chen J-H, Huang W-F, Liu M, Hong S-K, Zhang J-Y. Gastric schwannoma: A retrospective analysis of clinical characteristics, treatments, and outcomes. Asian J Surg 2024;47(1):407-12. [DOI:10.1016/j.asjsur.2023.09.042] [PMID]
15. Singh A, Mittal A, Garg B, Sood N. Schwannoma of the stomach: a case report. J Med Case Rep 2016;10:1-3. [DOI:10.1186/s13256-015-0788-0] [PMID] []
16. Miao G, Zhang D, Li J, Deng Y, Gu X, Feng T. Gastric schwannoma with post-surgical gastroparesis: a case report and literature review. Front Oncol 2025;14:1496074. [DOI:10.3389/fonc.2024.1496074] [PMID] []
17. Qi Z, Yang N, Pi M, Yu W. Current status of the diagnosis and treatment of gastrointestinal schwannoma. Oncol Lett 2021;21(5):384-90. [DOI:10.3892/ol.2021.12645] [PMID] []
18. Lauricella S, Valeri S, Mascianà G, Gallo IF, Mazzotta E, Pagnoni C, et al. What about gastric schwannoma? A review article. J Gastrointest Cancer 2021;52:57-67. [DOI:10.1007/s12029-020-00456-2] [PMID]
19. Wang J, Xie Z, Zhu X, Niu Z, Ji H, He L, et al. Differentiation of gastric schwannomas from gastrointestinal stromal tumors by CT using machine learning. Abdom Radiol 2021;46:1773-82. [DOI:10.1007/s00261-020-02797-9] [PMID]
20. Paramythiotis D, Karakatsanis A, Pagkou D, Bangeas P, Mantha N, Lypiridou S, et al. Gastric schwannoma: report of two cases and review of the literature. Int J Surg Case Rep 2018;53:495-9. [DOI:10.1016/j.ijscr.2018.10.062] [PMID] []
21. Pu C, Zhang K. Gastric schwannoma: a case report and literature review. J Int Med Res 2020;48(9):1-5. [DOI:10.1177/0300060520957828] [PMID] []
22. Yoon W, Paulson K, Mazzara P, Nagori S, Barawi M, Berri R. Gastric schwannoma: a rare but important differential diagnosis of a gastric submucosal mass. Case Rep Surg 2012;2012(1):7-12. [DOI:10.1155/2012/280982] [PMID] []
23. He M-Y, Zhang R, Peng Z, Li Y, Xu L, Jiang M, et al. Differentiation between gastrointestinal schwannomas and gastrointestinal stromal tumors by computed tomography. Oncol Lett 2017;13(5):3746-52. [DOI:10.3892/ol.2017.5955] [PMID] []
24. Hughes M, Thomas J, Fisher C, Moskovic E. Imaging features of retroperitoneal and pelvic schwannomas. Clin Radiol 2005;60(8):886-93. [DOI:10.1016/j.crad.2005.01.016] [PMID]
25. Hong X, Wu W, Wang M, Liao Q, Zhao Y. Benign gastric schwannoma: how long should we follow up to monitor the recurrence? A case report and comprehensive review of literature of 137 cases. Int Surg 2015;100(4):744-7. [DOI:10.9738/INTSURG-D-14-00106.1] [PMID] []
26. Raber MH, des Plantes CMZ, Vink R, Klaase JM. Gastric schwannoma presenting as an incidentaloma on CT-scan and MRI. Gastroenterol Res 2010;3(6):276-80. [DOI:10.4021/gr245w]
27. Zhong Z, Xu Y, Liu J, Zhang C, Xiao Z, Xia Y, et al. Clinicopathological study of gastric schwannoma and review of related literature. BMC Surg 2022;22(1):159-64. [DOI:10.1186/s12893-022-01613-z] [PMID] []
28. Kostovski O, Trajkovski G, Ristovski G, Kunovska SK, Kostovska I. Gastric schwannoma: a case report. J Surg Case Rep 2024;2024(3):1-5. [DOI:10.1093/jscr/rjae181] [PMID] []
29. Zhao L, Cao G, Shi Z, Xu J, Yu H, Weng Z, et al. Preoperative differentiation of gastric schwannomas and gastrointestinal stromal tumors based on computed tomography: a retrospective multicenter observational study. Front Oncol 2024;14:9-14. [DOI:10.3389/fonc.2024.1344150] [PMID] []

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