Volume 35, Issue 5 (August 2024)
Studies in Medical Sciences 2024, 35(5): 382-393 |
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Ethics code: IR.UMSU.REC.1401.151
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Broumand Sorkhabi F, Vazifekhah S, Esmailzadeh M. INVESTIGATING THE RATE OF PREMATURE DELIVERY AND LOW BIRTH WEIGHT IN MOTHERS WITH COVID-19 HOSPITALIZED IN KAUSAR URMIA HOSPITAL IN 1400 AND COMPARING IT WITH THE POPULATION OF NON-INFECTED MOTHERS. Studies in Medical Sciences 2024; 35 (5) :382-393
URL: http://umj.umsu.ac.ir/article-1-6304-en.html
URL: http://umj.umsu.ac.ir/article-1-6304-en.html
Associate Professor of Gynecology and Obstetrics, Maternal and Child Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran (Corresponding Author) , shabnam.vazifekhah@yahoo.com
Abstract: (378 Views)
Background & Aims: More than three years after the outbreak of the new SARS-CoV-2 virus, it remains a health concern for certain populations, including pregnant women. The purpose of this study is to investigate the rate of premature birth and low birth weight in pregnant women with COVID-19 infection and compare it with the population of non-infected mothers.
Materials & Methods: In this cohort study, 511 pregnant women whose COVID-19 infection was confirmed by a positive SARS-CoV-2 RT-PCR test or with clinical signs and symptoms of COVID-19 pneumonia, as well as 1018 pregnant women without infection, were included. Retrospectively, basic characteristics and data related to maternal and neonatal outcomes were collected from patient records and analyzed using SPSS v.26 software.
Results: The average gestational age at the time of delivery for pregnant women with COVID-19 infection and healthy pregnant women was 37 ± 4 days and 38 ± 2 days, respectively. The rate of cesarean delivery among pregnant women with COVID-19 was significantly higher than that of healthy pregnant women (P < 0.001). No statistical difference in neonatal outcomes was observed in terms of NICU admission rate, neonatal death, or Apgar score. Babies with low birth weight were more common in pregnant women with COVID-19 compared to healthy pregnant women (P < 0.001).
Conclusion: Pregnant mothers infected with COVID-19 have a higher risk of preeclampsia, cesarean delivery, premature delivery, ICU hospitalization, maternal death, and low birth weight of the baby. Additionally, there is a significant correlation between COVID-19 infection and these adverse outcomes. However, we did not observe a significant difference in Apgar scores, NICU admissions, or perinatal mortality. It seems that pregnant mothers with COVID-19 should be given special attention regarding the possibility of preeclampsia and the risk of premature birth.
Materials & Methods: In this cohort study, 511 pregnant women whose COVID-19 infection was confirmed by a positive SARS-CoV-2 RT-PCR test or with clinical signs and symptoms of COVID-19 pneumonia, as well as 1018 pregnant women without infection, were included. Retrospectively, basic characteristics and data related to maternal and neonatal outcomes were collected from patient records and analyzed using SPSS v.26 software.
Results: The average gestational age at the time of delivery for pregnant women with COVID-19 infection and healthy pregnant women was 37 ± 4 days and 38 ± 2 days, respectively. The rate of cesarean delivery among pregnant women with COVID-19 was significantly higher than that of healthy pregnant women (P < 0.001). No statistical difference in neonatal outcomes was observed in terms of NICU admission rate, neonatal death, or Apgar score. Babies with low birth weight were more common in pregnant women with COVID-19 compared to healthy pregnant women (P < 0.001).
Conclusion: Pregnant mothers infected with COVID-19 have a higher risk of preeclampsia, cesarean delivery, premature delivery, ICU hospitalization, maternal death, and low birth weight of the baby. Additionally, there is a significant correlation between COVID-19 infection and these adverse outcomes. However, we did not observe a significant difference in Apgar scores, NICU admissions, or perinatal mortality. It seems that pregnant mothers with COVID-19 should be given special attention regarding the possibility of preeclampsia and the risk of premature birth.
Keywords: SARS-CoV-2, COVID-19, pregnant women, pregnancy outcomes, low birth weight, neonatal outcomes, maternal outcomes, preterm labor
Type of Study: Research |
Subject:
زنان و زایمان
References
1. Rasouli J, Mousavi S J, Nazari H, Monazzami F. Comparison of the outcome of patients with reinfection and primary infection of covid-19 and its influencing factors in west azerbaijan province. Stud Med Sci 2024; 35 (2): 145-152. https: //doi.org/10.61186/umj.35.2.145 [URL:] [DOI:10.61186/umj.35.2.145]
2. Zardkoohi S, Bassaknejad S, Gheibizadeh M. Comparison of predictors of tokophobia in mothers in the last trimester and first six months of pregnancy based on metacognitive beliefs, corona anxiety, and ilness anxiety. Stud Med Sci 2022; 33 (9): 634-645. https: //doi.org/10.52547/umj.33.9.1 [URL:] [DOI:10.52547/umj.33.9.1]
3. Racicot K, Mor G. Risks associated with viral infections during pregnancy. J. Clin. Investig 2017;127(5): 1591-9. https: //doi.org/10.1172/JCI87490 [PMID: 28459427] [DOI:10.1172/JCI87490] [PMCID: PMC5409792]
4. Khezri R, Rezaei F, Jahanian S, Ebrahimi K. Severe COVID-19 and Its Related Factors in Pregnant Women: A Multi-Center Cross‐Sectional Study. Stud Med Sci 2023; 34 (7): 417-426. https: //doi.org/10.61186/umj.34.7.417 [URL:] [DOI:10.61186/umj.34.7.417]
5. Cugola FR, Fernandes IR, Russo FB, Freitas BC, Dias JL, Guimarães KP, et al. The Brazilian Zika virus strain causes birth defects in experimental models. Nature 2016;534(7606): 267-71. https: //doi.org/10.1038/nature18296 [PMID: 27279226] [DOI:10.1038/nature18296] [PMCID: PMC4902174]
6. Yockey LJ, Varela L, Rakib T, Khoury-Hanold W, Fink SL, Stutz B, et al. Vaginal exposure to Zika virus during pregnancy leads to fetal brain infection. Cell 2016;166(5): 1247-56. e4. https: //doi.org/10.1016/j.cell.2016.08.004 [PMID: 27565347] [DOI:10.1016/j.cell.2016.08.004] [PMCID: PMC5006689]
7. Kourtis AP, Read JS, Jamieson DJ. Pregnancy and infection. N Engl J Med 2014;370(23): 2211-8. https: //doi.org/10.1056/NEJMra1213566 [PMID: 24897084] [DOI:10.1056/NEJMra1213566] [PMCID: PMC4459512]
8. O'Day MP. Cardio-respiratory physiological adaptation of pregnancy. Semin Perinatol 1997;21(4): 268-75. https: //doi.org/10.1016/S0146-0005(97)80069-9
https://doi.org/10.1016/S0146-0005(97)80069-9 [PMID: 9298715] [DOI:10.1016/S0146-0005(97)80069-9]
9. Goodnight WH, Soper DE. Pneumonia in pregnancy. Crit Care Med 2005;33(10 Suppl): S390-7. https: //doi.org/10.1097/01.CCM.0000182483.24836.66 [PMID: 16215363] [DOI:10.1097/01.CCM.0000182483.24836.66]
10. Park MH, Kim HR, Choi DH, Sung JH, Kim JH. Emergency cesarean section in an epidemic of the middle east respiratory syndrome: a case report. Korean J Anesthesiol 2016;69(3): 287-91. https: //doi.org/10.4097/kjae.2016.69.3.287 [PMID: 27274377] [DOI:10.4097/kjae.2016.69.3.287] [PMCID: PMC4891544]
11. Zaigham M, Andersson O. Maternal and perinatal outcomes with COVID‐19: a systematic review of 108 pregnancies. Acta Obstet Gynecol Scand 2020;99(7): 823-9. https: //doi.org/10.1111/aogs.13867 [PMID: 32259279] [DOI:10.1111/aogs.13867] [PMCID: PMC7262097]
12. Smith V, Seo D, Warty R, Payne O, Salih M, Chin KL, et al. Maternal and neonatal outcomes associated with COVID-19 infection: A systematic review. Plos one 2020;15(6): e0234187. https: //doi.org/10.1371/journal.pone.0234187 [PMID: 32497090] [DOI:10.1371/journal.pone.0234187] [PMCID: PMC7272020]
13. Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. The lancet 2020;395(10226): 809-15. https: //doi.org/10.1016/S0140-6736(20)30360-3 [PMID: 32151335] [DOI:10.1016/S0140-6736(20)30360-3]
14. Ellington S, Strid P, Tong VT, Woodworth K, Galang RR, Zambrano LD, et al. Characteristics of women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status-United States, January 22-June 7, 2020. MMWR 2020;69(25): 769. https: //doi.org/10.1097/01.ogx.0000721400.07132.fc [PMID: 32584795] [DOI:10.15585/mmwr.mm6925a1]
15. D L, L L, X W, D Z, J W, L Y, et al. Pregnancy and Perinatal Outcomes of Women With Coronavirus Disease (COVID-19) Pneumonia: A Preliminary Analysis. AJR American journal of roentgenology [Internet]. 2020 Jul [cited 2024 Sep 23];215(1). Available from: https: //pubmed.ncbi.nlm.nih.gov/32186894/ https: //doi.org/10.2214/AJR.20.23072 [URL:] [DOI:10.2214/AJR.20.23072]
16. Vizheh M, Muhidin S, Aghajani F, Maleki Z, Bagheri F, Hosamirudsari H, et al. Characteristics and outcomes of COVID‐19 pneumonia in pregnancy compared with infected nonpregnant women. INT J GYNECOL OBSTET 2021;153(3): 462-8. https: //doi.org/10.1002/ijgo.13697 [PMID: 33829492] [DOI:10.1002/ijgo.13697] [PMCID: PMC9087605]
17. Radnia N, Alimohammadi N, Garousian M, Talebi-Ghane E, Basiri B, Bashirian S, et al. Comparison of Maternal and Neonatal Outcomes Among COVID-19 and Healthy Pregnant Women in the West of Iran: A Retrospective Cohort Study. Curr. Women's Health Rev 2023;19(4): 63-9. https: //doi.org/10.2174/1573404819666221101124433 [URL:] [DOI:10.2174/1573404819666221101124433]
18. Vizheh M, Allahdadian M, Ghasemi-Tehrani H, Muhidin S, Hashemi M, Dehghan M. Maternal and Neonatal Outcomes of COVID-19 Infection in Pregnancy. Arch Iran Med 2023;26(1): 43-9. https: //doi.org/10.34172/aim.2023.07 [PMID: 37543921] [DOI:10.34172/aim.2023.07] [PMCID: PMC10685811]
19. Damara FA, Muchamad GR, Ikhsani R, Hendro, Syafiyah AH, Bashari MH. Thyroid disease and hypothyroidism are associated with poor COVID-19 outcomes: A systematic review, meta-analysis, and meta-regression. Diabetes & Metabolic Syndrome: Clin. Res 2021;15(6): 102312. https: //doi.org/10.1016/j.dsx.2021.102312 [PMID: 34731819] [DOI:10.1016/j.dsx.2021.102312] [PMCID: PMC8530797]
20. Lin T-T, Zhang C, Zhang H-Q, Wang Y, Chen L, Dennis C-L, et al. Thyroid hormone changes in early pregnancy along with the COVID-19 pandemic. Front. Endocrinol 2020;11: 606723. https: //doi.org/10.3389/fendo.2020.606723 [PMID: 33365014] [DOI:10.3389/fendo.2020.606723] [PMCID: PMC7750518]
21. Lokken EM, Huebner EM, Taylor GG, Hendrickson S, Vanderhoeven J, Kachikis A, et al. Disease severity, pregnancy outcomes and maternal deaths among pregnant patients with SARS-CoV-2 infection in Washington State. Am J Obstet Gynecol 2021;225(77): e1-77. https: //doi.org/10.1016/j.ajog.2020.12.1221 [PMID: 33515516] [DOI:10.1016/j.ajog.2020.12.1221] [PMCID: PMC7838012]
22. Metz TD, Clifton RG, Hughes BL, Sandoval GJ, Grobman WA, Saade GR, et al. Association of SARS-CoV-2 infection with serious maternal morbidity and mortality from obstetric complications. Jama. 2022;327(8): 748-59. https: //doi.org/10.1001/jama.2022.1190 [PMID: 35129581] [PMCID: PMC8822445]
23. Abedzadeh‐Kalahroudi M, Sehat M, Vahedpour Z, Talebian P. Maternal and neonatal outcomes of pregnant patients with COVID‐19: a prospective cohort study. Int J Gynecol Obstet 2021;153(3): 449-56. https: //doi.org/10.1002/ijgo.13661 [PMID: 33638200] [DOI:10.1002/ijgo.13661] [PMCID: PMC9087533]
24. Pineles BL, Goodman KE, Pineles L, O'Hara LM, Nadimpalli G, Magder LS, et al. Pregnancy and the Risk of In-Hospital Coronavirus Disease 2019 (COVID-19) Mortality. Obstet. Gynecol 2022;139(5): 846. https: //doi.org/10.1097/AOG.0000000000004744 [PMID: 35576343] [DOI:10.1097/AOG.0000000000004744] [PMCID: PMC9015030]
25. Doyle TJ, Kiros Ge, Schmitt-Matzen EN, Propper R, Thompson A, Phillips-Bell GS. Maternal and Perinatal Outcomes Associated With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection During Pregnancy, Florida, 2020-2021: A Retrospective Cohort Study Clin. Infect. Dis 2022;75(Supplement_2): S308-S16. https: //doi.org/10.1093/cid/ciac441 [PMID: 35675310] [DOI:10.1093/cid/ciac441] [PMCID: PMC9214154]
26. Abedzadeh‐Kalahroudi M, Sehat M, Vahedpour Z, Talebian P. Maternal and neonatal outcomes of pregnant patients with COVID‐19: a prospective cohort study. Int J Gynecol Obstet 2021;153(3): 449-56. https: //doi.org/10.1002/ijgo.13661 [PMID: 33638200] [DOI:10.1002/ijgo.13661] [PMCID: PMC9087533]
27. Son M, Gallagher K, Lo JY, Lindgren E, Burris HH, Dysart K, et al. Coronavirus disease 2019 (COVID-19) pandemic and pregnancy outcomes in a US population. Obstet. Gynecol 2021;138(4): 542. https: //doi.org/10.1097/AOG.0000000000004547 [PMID: 34433180] [DOI:10.1097/AOG.0000000000004547] [PMCID: PMC8454282]
28. Pirjani R, Hosseini R, Soori T, Rabiei M, Hosseini L, Abiri A, et al. Maternal and neonatal outcomes in COVID-19 infected pregnancies: a prospective cohort study. J. Travel Med 2020;27(7). https: //doi.org/10.1093/jtm/taaa158 [PMID: 32889551] [DOI:10.1093/jtm/taaa158] [PMCID: PMC7499693]
29. Wei SQ, Bilodeau-Bertrand M, Liu S, Auger N. The impact of COVID-19 on pregnancy outcomes: a systematic review and meta-analysis. CMA J 2021;193(16): E540-E8. https: //doi.org/10.1503/cmaj.202604 [PMID: 33741725] [DOI:10.1503/cmaj.202604] [PMCID: PMC8084555]
30. Smith ER, Oakley E, Grandner GW, Ferguson K, Farooq F, Afshar Y, et al. Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis. BMJ Global Health 2023;8(1): e009495. https: //doi.org/10.1136/bmjgh-2022-009495 [PMID: 36646475] [DOI:10.1136/bmjgh-2022-009495] [PMCID: PMC9895919]
31. Mullins E, Perry A, Banerjee J, Townson J, Grozeva D, Milton R, et al. Pregnancy and neonatal outcomes of COVID-19: The PAN-COVID study. Eur. J. Obstet. Gynecol. Reprod. Biol 2022;276: 161-7. [PMID: 35914420] [PMCID: PMC9295331]
32. Hughes BL, Sandoval GJ, Metz TD, Clifton RG, Grobman WA, Saade GR, et al. First-or second-trimester SARS-CoV-2 infection and subsequent pregnancy outcomes. AJOG 2023;228(2): 226. e1-. e9. https: //doi.org/10.1016/j.ajog.2022.08.009 [PMID: 35970201] [DOI:10.1016/j.ajog.2022.08.009] [PMCID: PMC9374493]
33. Davaryari N, Davaryar S, Azarshab A, Vakilzadeh MM, Vakili V, Moazzeni Z. Comparison of maternal and fetal health outcomes in the pandemic period of covid-19 with the same last year duration in health centers of second largest city of Iran: A population-based cohort study. Heliyon 2023;9(3). https: //doi.org/10.1016/j.heliyon.2023.e14439 [PMID: 36942237] [DOI:10.1016/j.heliyon.2023.e14439] [PMCID: PMC9998123]
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