Volume 35, Issue 5 (August 2024)
Studies in Medical Sciences 2024, 35(5): 394-403 |
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Pourdadash Shahrak J, Alinezhad B, Masoudi N. INVESTIGATING THE EFFECT OF BETA-ALANINE ON CLINICAL OUTCOMES IN PATIENTS WITH ACUTE LIMB ISCHEMIA AFTER SURGERY. Studies in Medical Sciences 2024; 35 (5) :394-403
URL: http://umj.umsu.ac.ir/article-1-6288-en.html
URL: http://umj.umsu.ac.ir/article-1-6288-en.html
Department of General Surgery, School of Medicine, Urmia University of Medical Sciences, Urmia,Iran. & Associate Professor and Colorectal Surgery Fellowship, Department of General Surgery, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran (Corresponding Author) , dr.nasmasoudi@gmail.com
Abstract: (227 Views)
Background & Aim: Acute limb ischemia remains a significant cause of emergency vascular surgery. Given the severe complications associated with this condition and the need for more effective treatments, this study was conducted to evaluate the impact of beta-alanine on clinical outcomes in patients with acute upper or lower limb ischemia following surgery.
Materials & Methods: This single-blind clinical trial enrolled 40 patients with acute limb ischemia without gangrene or mottling and who required amputation. Patients were randomly assigned to a beta-alanine group (n=20) or a placebo group (n=20). The intervention group received 4 grams of oral beta-alanine before surgery and 4 hours postoperatively, while the placebo group received a matching placebo. Primary outcomes included limb loss frequency and extent, while secondary outcomes were mortality and laboratory findings.
Results: A total of 9 patients (22.5%) experienced limb loss. Of these, only 1 patient (5%) was in the beta-alanine group, compared to 8 patients (40%) in the placebo group (p=0.02). In the beta-alanine group, the affected limb was the right lower extremity. In the placebo group, one patient lost the right upper limb, two lost the right lower limb, four lost the left upper limb, and one lost the left lower limb. There was no significant difference in mortality between the groups (5% in the beta-alanine group versus 15% in the placebo group; p=0.61).
Conclusion: The frequency of limb loss was significantly lower in patients treated with 4 grams of oral beta-alanine compared to the placebo group. Therefore, beta-alanine may be considered an effective adjunctive therapy in reducing the risk of limb loss in patients with acute limb ischemia.
Materials & Methods: This single-blind clinical trial enrolled 40 patients with acute limb ischemia without gangrene or mottling and who required amputation. Patients were randomly assigned to a beta-alanine group (n=20) or a placebo group (n=20). The intervention group received 4 grams of oral beta-alanine before surgery and 4 hours postoperatively, while the placebo group received a matching placebo. Primary outcomes included limb loss frequency and extent, while secondary outcomes were mortality and laboratory findings.
Results: A total of 9 patients (22.5%) experienced limb loss. Of these, only 1 patient (5%) was in the beta-alanine group, compared to 8 patients (40%) in the placebo group (p=0.02). In the beta-alanine group, the affected limb was the right lower extremity. In the placebo group, one patient lost the right upper limb, two lost the right lower limb, four lost the left upper limb, and one lost the left lower limb. There was no significant difference in mortality between the groups (5% in the beta-alanine group versus 15% in the placebo group; p=0.61).
Conclusion: The frequency of limb loss was significantly lower in patients treated with 4 grams of oral beta-alanine compared to the placebo group. Therefore, beta-alanine may be considered an effective adjunctive therapy in reducing the risk of limb loss in patients with acute limb ischemia.
Type of Study: Research |
Subject:
جراحی عمومی
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