Volume 35, Issue 2 (May 2024)                   Studies in Medical Sciences 2024, 35(2): 116-125 | Back to browse issues page


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Hosseinzadeh F. INVESTIGATING THE ROLE OF TUMOR NECROSIS FACTOR ALPHA IN WEIGHT LOSS IN ACUTE AND CHRONIC SYSTEMIC HYPOXIA MODEL. Studies in Medical Sciences 2024; 35 (2) :116-125
URL: http://umj.umsu.ac.ir/article-1-6205-en.html
Assistant Professor of the Department of Physiology, Sarab Faculty of Medical Sciences, Sarab, Iran (Corresponding Author) , Hossenzadeh_fez@yahoo.com
Abstract:   (1455 Views)
Background & Aims: Body weight loss is a common complication in hypoxic conditions. Several studies have reported that hypoxia increases the production of tumor necrosis factor-alpha (TNF-α) in in vitro and in vivo models. The present study investigates the role of circulating TNF-α concentration in body weight loss in acute and chronic systemic hypoxia.
Materials & Methods: In this experimental study, 28 adults male Wistar rats were divided into four acute or chronic control and acute or chronic hypoxia groups. Animals were exposed to room air with 21% oxygen level or hypoxia with 10-11% oxygen level in a normobaric hypoxic chamber for two days (acute) or ten days (chronic). TNF-α concentration was evaluated using the ELISA method. SPSS version 17 software was used for data analysis. The findings related to the weight of rats were used from the paired-sample t-test, and the data related to the concentration of tumor necrosis factor-alpha from the Two-tailed Student's t-test. Differences were considered significant at p>0.05 level.
Results: The results showed that acute (p < 0.001) and chronic (p < 0.05) hypoxia caused a significant increase in the concentration of TNF-α in the serum, as well as induction of acute (p < 0.01) and chronic (p < 0.001) systemic hypoxia.) significantly decreased body weight before and after hypoxia induction.
Conclusion: Our findings show that acute and chronic systemic hypoxia is associated with increased serum levels of TNF-α, and acute and chronic systemic hypoxia is associated with weight loss. Due to the association of TNF-α with weight loss, the increase of TNF-α may be the reason for body weight loss in hypoxic conditions.
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Type of Study: Research | Subject: فیزیولوژی

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