1. Dong Z, Wang JZ, Yu F, Venkatachalam MA. Apoptosis-resistance of hypoxic cells: multiple factors involved and a role for IAP-2. Am J Pathol 2003;163(2):663-71. doi: 10.1016/S0002-9440(10)63693-0 [
DOI:10.1016/S0002-9440(10)63693-0] [
PMID]
2. Castillejos-López M, Romero Y, Varela-Ordoñez A, Flores-Soto E, Romero-Martinez BS, Velázquez-Cruz R, et al. Hypoxia induces alterations in the circadian rhythm in patients with chronic respiratory diseases. Cells 2023;12(23):2724. doi: 10.3390/cells12232724 [
DOI:10.3390/cells12232724] [
PMID] [
]
3. Kanaan A, Farahani R, Douglas RM, Lamanna JC, Haddad GG. Effect of chronic continuous or intermittent hypoxia and reoxygenation on cerebral capillary density and myelination. Am J Physiol Regul Integr Comp Physiol 2006;290(4): R1105-14. doi: 10.1152/ajpregu.00535.2005 [
DOI:10.1152/ajpregu.00535.2005] [
PMID]
4. Dewhirst MW, Cao Y, Moeller B. Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat Rev Cancer 2008;8:425-36
https://doi.org/10.1038/nrc2438 [
DOI:10.1038/nrc2397] [
PMID] [
]
5. Sorg BS, Moeller BJ, Donovan O, Cao Y, Dewhirst MW. Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development. J Biomed Opt 2005;10(4):44004. doi:10.1117/1.2003369 [
DOI:10.1117/1.2003369] [
PMID]
6. Lippl FJ, Neubauer S, Schipfer S, Lichter N, Tufman A, Otto B, et al. Hypobaric hypoxia causes body weight reduction in obese subjects. Obesity (Silver Spring) 2010;18(4):675-81. doi: 10.1038/oby.2009.509 [
DOI:10.1038/oby.2009.509] [
PMID]
7. Wang R, Guo S, Tian H, Huang Y, Yang Q, Zhao K, et al. Hypoxic training in obese mice improves metabolic disorder. Front Endocrinol (Lausanne) 2019;8;10:527. doi: 10.3389/fendo.2019. 00527 [
DOI:10.3389/fendo.2019.00527] [
PMID] [
]
8. Castillo-Rodríguez RA, Trejo-Solís C, Cabrera-Cano A, Gómez-Manzo S, Dávila-Borja VM. Hypoxia as a Modulator of Inflammation and Immune Response in Cancer. Cancers (Basel) 2022;14(9):2291. doi: 10.3390/cancers14092291 [
DOI:10.3390/cancers14092291] [
PMID] [
]
9. Qiu B, Yuan P, Du X, Jin H, Du J, Huang Y. Hypoxia inducible factor-1α is an important regulator of macrophage biology. Heliyon 2023;9(6):e17167. doi: 10.1016/j.heliyon. 2023.e17167 [
DOI:10.1016/j.heliyon.2023.e17167] [
PMID] [
]
10. Nosrati Hashi A, Bolboli L, Anoushiravani S, Farzizadeh R. The effect of a period of resistance training with blood flow restriction on the level of IL-6, IGA and TNF-α in judokas. Stud Med Sci 2022;33(9):661-75. URL: http://umj.umsu.ac.ir/article-1-5877-fa.html [
DOI:10.52547/umj.33.9.4]
11. Qu Y, Zhao G, Li H. Forward and reverse signaling mediated by transmembrane tumor necrosis factor-alpha and TNF receptor 2: Potential roles in an immunosuppressive tumor microenvironment. Front Immunol 2017;8:1675. doi: 10.3389/fimmu.2017.01675. [
DOI:10.3389/fimmu.2017.01675] [
PMID] [
]
12. Takabatake N, Nakamura H, Abe S, Inoue S, Hino T, Saito H, et al. The relationship between chronic hypoxemia and activation of the tumor necrosis factor-alpha system in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2000;161(4 Pt 1):1179-84. doi: 10.1164/ajrccm.161.4.9903022 [
DOI:10.1164/ajrccm.161.4.9903022] [
PMID]
13. Sethi JK, Hotamisligil GS. Metabolic Messengers: Tumour necrosis factor. Nat Metab 2021;3(10):1302-1312. doi: 10.1038/s42255-021-00470-z. [
DOI:10.1038/s42255-021-00470-z] [
PMID]
14. Perry SW, Dewhurst S, Bellizzi MJ, Gelbard HA. Tumor necrosis factor-alpha in normal and diseased brain: Conflicting effects via intraneuronal receptor crosstalk? J Neurovirol 2002;8(6):611-24. doi: 10.1080/13550280290101021 [
DOI:10.1080/13550280290101021] [
PMID] [
]
15. Liu FQ, Liu Y, Lui VC, Lamb JR, Tam PK, Chen Y. Hypoxia modulates lipopolysaccharide induced TNF-alpha expression in murine macrophages. Exp Cell Res 2008; 314(6):1327-36. doi: 10.1016/j.yexcr.2008.01.007 [
DOI:10.1016/j.yexcr.2008.01.007] [
PMID]
16. de Kloet AD, Pacheco-López G, Langhans W, Brown LM. The effect of TNFα on food intake and central insulin sensitivity in rats. Physiol Behav 2011;103(1):17-20. doi: 10.1016/j.physbeh.2010.11.037. [
DOI:10.1016/j.physbeh.2010.11.037] [
PMID] [
]
17. Plata-Salamán CR, Oomura Y, Kai Y. Tumor necrosis factor and interleukin-1 beta: suppression of food intake by direct action in the central nervous system. Brain Res 1988;448(1):106-14. doi: 10.1016/0006-8993(88)91106-7 [
DOI:10.1016/0006-8993(88)91106-7] [
PMID]
18. Banks WA. Anorectic effects of circulating cytokines: role of the vascular blood-brain barrier. Nutrition 2001;17(5):434-7. doi: 10.1016/s0899-9007(01)00507-x [
DOI:10.1016/S0899-9007(01)00507-X] [
PMID]
19. Patel HJ, Patel BM. TNF-α and cancer cachexia: Molecular insights and clinical implications. Life Sci 2017;170:56-63. doi: 10.1016/j.lfs.2016.11.033 [
DOI:10.1016/j.lfs.2016.11.033] [
PMID]
20. Tisdale MJ. Mechanisms of cancer cachexia. Physiol Rev. 2009;89(2):381-410. doi: 10.1152/physrev.00016.2008 [
DOI:10.1152/physrev.00016.2008] [
PMID]
21. Arruda AP, Milanski M, Romanatto T, Solon C, Coope A, Alberici LC, et al. Hypothalamic actions of tumor necrosis factor alpha provide the thermogenic core for the wastage syndrome in cachexia. Endocrinology 2010;151(2):683-94. doi: 10.1210/en.2009-0865 [
DOI:10.1210/en.2009-0865] [
PMID]
22. Bazzoni F, Beutler B. The tumor necrosis factor ligand and receptor families. N Engl J Med 1996;334(26):1717-25. doi:10.1056/NEJM199606273342607 [
DOI:10.1056/NEJM199606273342607] [
PMID]
23. Mahony SM, Beck SA, Tisdale MJ. Comparison of weight loss induced by recombinant tumour necrosis factor with that produced by a cachexia-inducing tumour. Br J Cancer 1988;57(4):385-9. doi: 10.1038/bjc.1988.87 [
DOI:10.1038/bjc.1988.87] [
PMID] [
]
24. Abidkanjo F, Soleimani N, Hosseini S M, Zanotti G. Immunological effects of FLGE2 recombinant protein in helicobacter pylori on TNF-α cytokine production in macrophage cells in vitro. Stud Med Sci 2022;33(1):45-53. URL: http://umj.umsu.ac.ir/article-1-5786-fa.html [
DOI:10.52547/umj.33.1.45]
25. la Fleur SE, Akana SF, Manalo SL, Dallman MF. Interaction between corticosterone and insulin in obesity: regulation of lard intake and fat stores. Endocrinology 2004;145(5):2174-85. doi: 10.1210/en.2003-1359 [
DOI:10.1210/en.2003-1359] [
PMID]
26. Xu NY, Chen XQ, Du JZ, Wang TY, Duan C. Intermittent hypoxia causes a suppressed pituitary growth hormone through somatostatin. Neuro Endocrinol Lett 2004;25(5):361-7 [
Google Scholar]
27. Babri S, Mohaddes G, Alipour M R, Ebrahimi H, Hossenzadeh F. Effects of Ghrelin on Plasma Glucose Levels, Body Weight, Food Intake and Hematocrit in Acute and Chronic Systemic Hypoxia in Adult Male Rats. IJEM 2013;15(1):100-6 [
Google Scholar]
28. Chen XQ, Dong J, Niu CY, Fan JM, Du JZ. Effects of hypoxia on glucose, insulin, glucagon, and modulation by corticotropin-releasing factor receptor type 1 in the rat. Endocrinology 2007;148(7):3271-8. doi: 10.1210/en.2006-1224 [
DOI:10.1210/en.2006-1224] [
PMID]
29. Webster JM, Kempen LJAP, Hardy RS, Langen RCJ. Inflammation and Skeletal Muscle Wasting During Cachexia. Front Physiol 2020;11:597675. doi:10.3389/fphys.2020.597675 [
DOI:10.3389/fphys.2020.597675] [
PMID] [
]
30. Tschöp M, Morrison KM. Weight loss at high altitude. Adv Exp Med Biol 2001;502:237-47. doi:10.1007/978-1-4757-3401-0_16 [
DOI:10.1007/978-1-4757-3401-0_16] [
PMID]
31. Tschöp M, Strasburger CJ, Hartmann G, Biollaz J, Bärtsch P. Raised leptin concentrations at high altitude associated with loss of appetite. Lancet 1998;352(9134):1119-20. doi:10.1016/S0140-6736(05)79760-9 [
DOI:10.1016/S0140-6736(05)79760-9] [
PMID]
32. Cartee GD, Douen AG, Ramlal T, Klip A, Holloszy JO. Stimulation of glucose transport in skeletal muscle by hypoxia. J Appl Physiol 1991;70(4):1593-600. doi:10.1152/jappl.1991.70.4.1593 [
DOI:10.1152/jappl.1991.70.4.1593] [
PMID]
33. Boghrabadi V, Piri MA, Sadeghi HE, Sankian M. Effects of aerobic training on leptin, tumor necrosis factor-α and interleukin-6 levels in obese and lean men Koomesh 1388;11(1):33-40. URL: http://koomeshjournal.semums.ac.ir/article-1-608-en.html. [
Google Scholar]
34. Gholamian S, Attarzadehosseini S, Rashidlamir A, Aghaalinejad H, Shariatzade M. Effect of a period of in terval training on expression of the TGF-Β cytokine gene inducing the epithelial to mesenchymal transition, tumor volume, and cachexia in mice with breast cancer: An experimental study. Stud Med Sci 2019;30(6):502-12. URL: http://umj.umsu.ac.ir/article-1-4788-fa.html [
Google Scholar]
35. Hempel SL, Monick MM, Hunninghake GW. Effect of hypoxia on release of IL-1 and TNF by human alveolar macrophages. Am J Respir Cell Mol Biol 1996;14(2):170-6. doi: 10.1165/ajrcmb.14.2.8630267 [
DOI:10.1165/ajrcmb.14.2.8630267] [
PMID]
36. Scannell G, Waxman K, Kaml GJ, Ioli G, Gatanaga T, Yamamoto R, et al. Hypoxia induces a human macrophage cell line to release tumor necrosis factor-alpha and its soluble receptors in vitro. J Surg Res 1993;54(4):281-5. doi: 10.1006/jsre [
DOI:10.1006/jsre.1993.1044] [
PMID]
37. Di Francia M, Barbier D, Mege JL, Orehek J. Tumor necrosis factor-alpha levels and weight loss in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1994;150(5 Pt 1):1453-5. doi: 10.1164/ajrccm.150.5.7952575 [
DOI:10.1164/ajrccm.150.5.7952575] [
PMID]
38. Patsalos O, Dalton B, Leppanen J, Ibrahim MAA, Himmerich H. Impact of TNF-α inhibitors on body weight and BMI: A systematic review and meta-analysis. Front Pharmacol 2020;11:481. doi: 10.3389/fphar.2020.00481 [
DOI:10.3389/fphar.2020.00481] [
PMID] [
]
39. Briot K, Garnero P, Le Henanff A, Dougados M, Roux C. Body weight, body composition, and bone turnover changes in patients with spondyloarthropathy receiving anti-tumour necrosis factor {alpha} treatment. Ann Rheum Dis 2005;64(8):1137-40. doi: 10.1136/ard.2004.028670 [
DOI:10.1136/ard.2004.028670] [
PMID] [
]
40. Amaral ME, Barbuio R, Milanski M, Romanatto T, Barbosa HC, Nadruz W, et al. Tumor necrosis factor-alpha activates signal transduction in hypothalamus and modulates the expression of pro-inflammatory proteins and orexigenic/anorexigenic neurotransmitters. J Neurochem 2006;98(1):203-12. doi: 10.1111/j.1471-4159.2006. 03857.x [
DOI:10.1111/j.1471-4159.2006.03857.x] [
PMID]
41. Romanatto T, Cesquini M, Amaral ME, Roman EA, Moraes JC, Torsoni MA, et al. TNF-alpha acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient--effects on leptin and insulin signaling pathways. Peptides 2007;28(5):1050-8. doi: 10.1016/j.peptides.2007.03.006 [
DOI:10.1016/j.peptides.2007.03.006] [
PMID]
42. Le Thuc O, Stobbe K, Cansell C, Nahon JL, Blondeau N, Rovère C. Hypothalamic Inflammation and Energy Balance Disruptions: Spotlight on Chemokines. Front Endocrinol (Lausanne) 2017; 8:197. doi: 10.3389/fendo.2017.00197 [
DOI:10.3389/fendo.2017.00197] [
PMID] [
]
43. Rydén M, Arvidsson E, Blomqvist L, Perbeck L, Dicker A, Arner P. Targets for TNF-alpha-induced lipolysis in human adipocytes. Biochem Biophys Res Commun 2004;318(1):168-75. doi: 10.1016/j.bbrc.2004.04.010 [
DOI:10.1016/j.bbrc.2004.04.010] [
PMID]
44. Zhang Y, Jin W, Zhang D, Lin C, He H, Xie F, et al. TNF-α antagonizes the effect of leptin on insulin secretion through FOXO1-dependent transcriptional suppression of LepRb in INS-1 cells. Oxid Med Cell Longev 2022;2022:9142798. doi: 10.1155/2022/9142798 [
DOI:10.1155/2022/9142798] [
PMID] [
]
45. Grunfeld C, Zhao C, Fuller J, Pollack A, Moser A, Friedman J, Feingold KR. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. J Clin Invest 1996;97(9):2152-7. doi:10.1172/JCI118653 [
DOI:10.1172/JCI118653] [
PMID] [
]