Volume 34, Issue 10 (12-2023)
Studies in Medical Sciences 2023, 34(10): 651-660 |
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Khalife Nezhad M, Lotfollahi Hagghi L, Abbasi Eslamloo A, Gheibi S, Esmaeili A. EVALUATION OF ANTIBIOTIC RESISTANCE PATTERNS IN PATIENTS ADMITTED TO INTENSIVE CARE UNITS OF IMAM KHOMEINI TEACHING HOSPITALS, URMIA. Studies in Medical Sciences 2023; 34 (10) :651-660
URL: http://umj.umsu.ac.ir/article-1-5959-en.html
URL: http://umj.umsu.ac.ir/article-1-5959-en.html
Mahin Khalife Nezhad 
, Lida Lotfollahi Hagghi 
, Ata Abbasi Eslamloo , Shayesteh Gheibi , Ayda Esmaeili *
, Lida Lotfollahi Hagghi , Ata Abbasi Eslamloo , Shayesteh Gheibi , Ayda Esmaeili *
Assistant Professor, Department of clinical pharmacy, school of pharmacy, Urmia University of Medical Sciences , ph.a.esmaeili@gmail.com
Abstract: (1460 Views)
Background & Aim: The increasing prevalence of antibiotic resistance is a major health problem. The present study was designed and implemented to evaluate antibiotic resistance patterns in the patients admitted to Intensive Care Units of Imam Khomeini hospital in Urmia from September 2020 to September 2021.
Material & Methods: In this descriptive-cross-sectional study that was conducted from September 2020 to September 2021, all cell cultures of blood, urine, sputum and respiratory secretions, cerebrospinal fluid (CSF), synovial fluid, and peritoneal fluid of the patients admitted to the ICU of Imam Khomeini Hospital in Urmia were analyzed by a complete counting method.
the descriptive cross-sectional study over September 2020 till September 2021, through systemic sampling, all bacterial cultures of blood, urine, sputum and respiratory secretions, cerebrospinal fluid, synovial fluid, peritoneal fluid of the patients admitted in the ICU of imam Khomeini hospital were evaluated. Statistical analysis was conducted by SPSS 22. The significance level in this study was considered less than 0.05.
Results: In this study, a total of 1862 culture mediums were examined, of which 1162 mediums (62.4%) had negative cultures. Also, in 348 mediums (18.60%), there were mixed fungi or bacteria. Also, 22 samples were excluded from the study due to incomplete antibiogram reporting. Finally, 330 mediums were examined with the specific result of the type of bacteria grown to check microbial resistance. The most common microorganisms isolated from urine, blood, and sputum cultures were Escherichia coli, Klebsiella, and Acinetobacter, respectively. Out of 34 mediums belonging to Staphylococcus aureus, one case was resistant to methicillin and three cases were resistant to cephalexin. Out of 252 mediums belonging to Gram-negative bacteria, ESBL, MDR, PDR and XDR were present in 61.5%, 88.1%, 34.5% and 11.5%, respectively. Antibiogram was used in 314 cases (98.5%) and did not match in 16 cases (1.5%).
Conclusion: The present study shows the risk of increasing microbial resistance, exposure to treatment-resistant strains, and the risk of non-response to antibiotic treatment in the patients. Therefore, necessary managements should be taken to prevent the unreasonable prescription of antibiotics and the intensification of the resistance process.
Material & Methods: In this descriptive-cross-sectional study that was conducted from September 2020 to September 2021, all cell cultures of blood, urine, sputum and respiratory secretions, cerebrospinal fluid (CSF), synovial fluid, and peritoneal fluid of the patients admitted to the ICU of Imam Khomeini Hospital in Urmia were analyzed by a complete counting method.
the descriptive cross-sectional study over September 2020 till September 2021, through systemic sampling, all bacterial cultures of blood, urine, sputum and respiratory secretions, cerebrospinal fluid, synovial fluid, peritoneal fluid of the patients admitted in the ICU of imam Khomeini hospital were evaluated. Statistical analysis was conducted by SPSS 22. The significance level in this study was considered less than 0.05.
Results: In this study, a total of 1862 culture mediums were examined, of which 1162 mediums (62.4%) had negative cultures. Also, in 348 mediums (18.60%), there were mixed fungi or bacteria. Also, 22 samples were excluded from the study due to incomplete antibiogram reporting. Finally, 330 mediums were examined with the specific result of the type of bacteria grown to check microbial resistance. The most common microorganisms isolated from urine, blood, and sputum cultures were Escherichia coli, Klebsiella, and Acinetobacter, respectively. Out of 34 mediums belonging to Staphylococcus aureus, one case was resistant to methicillin and three cases were resistant to cephalexin. Out of 252 mediums belonging to Gram-negative bacteria, ESBL, MDR, PDR and XDR were present in 61.5%, 88.1%, 34.5% and 11.5%, respectively. Antibiogram was used in 314 cases (98.5%) and did not match in 16 cases (1.5%).
Conclusion: The present study shows the risk of increasing microbial resistance, exposure to treatment-resistant strains, and the risk of non-response to antibiotic treatment in the patients. Therefore, necessary managements should be taken to prevent the unreasonable prescription of antibiotics and the intensification of the resistance process.
Keywords: Antibiotic Resistance Pattern, Extended-Spectrum Beta-Lactamases, Methicillin-Resistant Staphylococcus Aureus, Multidrug-Resistant Bacteria
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