Volume 34, Issue 1 (April 2023)                   Studies in Medical Sciences 2023, 34(1): 12-20 | Back to browse issues page

Ethics code: IR.UMSU.REC.1400.100

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URL: http://umj.umsu.ac.ir/article-1-5917-en.html
Department of pathology,Faculty of medicine , Urmia university of medical science , Urmia,Iran , farzanehjavanmard@yahoo.com
Abstract:   (1029 Views)
Background & Aims: Cervical cancer is the fourth most frequently diagnosed cancer in women. Colposcopy is a worldwide accepted method for detection of early carcinoma of cervix. This study was conducted to investigate the correlation between colposcopic examination results with histopathological findings and its diagnostic value in cervical biopsy.
Materials & Methods: This study was a cross-sectional comparative study performed on 436 women with abnormal Pap smear test results, referring to Urmia Motahari Hospital during March 2021 to March 2022. Colposcopy and histopathologic findings of individuals with abnormal Pap smear results were extracted from the patient records. The data were analyzed using descriptive and analytic statistics (Chi-square test) using SPSS 21 (SPSS Inc., Chicago, IL.,USA). The sensitivity, specificity, and positive and negative predictive values of various diagnostic methods were calculated. A probability of P<0.05 was accepted as significant.
Results: The mean age of the participants was 37.3 ± 9.60. The most common finding in colposcopy and histopathology results were acetowhite lesions and cervicitis, respectively. According to the comparison, the agreement percentage of colposcopy and histopathology findings in noninvasive malignant neoplasia in the case of CINIII, CINII, CINI were 4%, 57.1%, and 37%, respectively. Sensitivity, specificity, and positive and negative predictive values for colposcopy in cervical intraepithelial neoplasia were reported as 57.3%, 51.8%, 23.3%, and 82.5%, respectively.
Conclusion: This study showed an acceptable correlation between colposcopic examination and histopathologic findings. Thus colposcopy can be used as a tool for early diagnosis of precancerous cervical lesions as a screening method alongside the pap smear. The correlation between the experience of examiner and accuracy of colposcopy results were not meaningful.
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Type of Study: Research | Subject: پاتولوژی

1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: Cancer J Clin 2018;68(6):394-424. [DOI:10.3322/caac.21492] [PMID]
2. Khorasanizadeh F, Hassanloo J, Khaksar N, Taheri SM, Marzaban M, Rashidi BH, et al. Epidemiology of cervical cancer and human papilloma virus infection among Iranian women-Analyses of national data and systematic review of the literature. Gynecol Oncol 2013;128(2):277-81. [DOI:10.1016/j.ygyno.2012.11.032] [PMID]
3. Taheri N, Fazel A, Mahmoodzadeh H, Omranpour R, Roshandel G, Gharahjeh S, et al. Epidemiology of female reproductive cancers in Iran: results of the Gholestan Population-based Cancer Registry. Asian Pac J Cancer Prev 2014;15(20):8779-82. [DOI:10.7314/APJCP.2014.15.20.8779] [PMID]
4. Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J.Pathol.1999;189(1):12-9. https://doi.org/10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F [DOI:10.1002/(SICI)1096-9896(199909)189:13.0.CO;2-F]
5. Nasiell K, Roger V, Nasiell M. Behavior of mild cervical dysplasia during long-term follow-up. Obstet Gynecol 1986;67(5):665-9. [DOI:10.1097/00006250-198605000-00012] [PMID]
6. Akhter S, Bari A, Hayat Z. Variability study between Pap smear, Colposcopy and Cervical Histopathology findings. J Pak Med Assoc 2015;65(12):1295-9. [PMID]
7. Hinselmann H. Verbesserung der inspektionsmöglichkeiten von vulva, vagina und portio. Muench Med Wochenschr 1925;72:1733.
8. Reid R, Scalzi P. Genital warts and cervical cancer: VII. An improved colposcopic index for differentiating benign papillomaviral infections from high-grade cervical intraepithelial neoplasia. Am J Obstet Gynecol 1985;153(6):611-8. [DOI:10.1016/S0002-9378(85)80244-1] [PMID]
9. Bornstein J, Bentley J, Bösze P, Girardi F, Haefner H, Menton M, et al. 2011 colposcopic terminology of the International Federation for Cervical Pathology and Colposcopy. Obstet Gynecol 2012;120(1):166-72. [DOI:10.1097/AOG.0b013e318254f90c] [PMID]
10. Strander B, Ellström-Andersson A, Franzén S, Milsom I, Rådberg T. The performance of a new scoring system for colposcopy in detecting high-grade dysplasia in the uterine cervix. Acta Obstet Gynecol Scand 2005;84(10):1013-7. [DOI:10.1111/j.0001-6349.2005.00895.x] [PMID]
11. Massad LS, Collins YC. Strength of correlations between colposcopic impression and biopsy histology. Gynecol Oncol 2003;89(3):424-8. [DOI:10.1016/S0090-8258(03)00082-9] [PMID]
12. Baum ME, Rader JS, Gibb RK, McAlister RP, Powell MA, Mutch DG, et al. Colposcopic accuracy of obstetrics and gynecology residents. Gynecol Oncol 2006;103(3):966-70. [DOI:10.1016/j.ygyno.2006.06.002] [PMID]
13. Moss EL, Hadden P, Douce G, Jones PW, Arbyn M, Redman CW. Is the colposcopically directed punch biopsy a reliable diagnostic test in women with minor cytological lesions? J Low Genit Tract Dis 2012;16(4):421-6. [DOI:10.1097/LGT.0b013e318250acf3] [PMID]
14. Sankaranarayanan R, Budukh AM, Rajkumar R. Effective screening programmes for cervical cancer in low-and middle-income developing countries. Bull World Health Organ 2001;79(10):954-62. [Google Scholar]
15. Panwar K, Tyagi S, Maheshwari B. Correlation of colposcopic findings with biopsy in cervical cancer screening. Hindu;79:26.3. [Google Scholar]
16. Patil P, Sharma P. Colposcopic evaluation of cervical erosion in symptomatic women. Int J Reprod Contracept Obstet Gynecol 2017;6(6):2207-12. [DOI:10.18203/2320-1770.ijrcog20172025]
17. Bai A, Wang J, Li Q, Seery S, Xue P, Jiang Y. Assessing colposcopic accuracy for high‐grade squamous intraepithelial lesion detection: a retrospective, cohort study. BMC Women Health 2022;22(1):1-8. [DOI:10.1186/s12905-022-01592-6] [PMID] [PMCID]
18. Jesmin ZF, Khanam A, Saha E, Hossain MM. Clinical effectiveness of VIA and colposcopy based management of cervical intraepithelial neoplasia. Bangladesh Med J 2014;47(1-2):16-20. [DOI:10.3329/bmjk.v47i1-2.22557]
19. Kiran P, Ajay B. Cancer cervix-need for mass surveillance program specially in Rural areas. J Obstet Gynecol India 2005;55(5):436-9. [URL]
20. Goel A, Gandhi G, Batra S, Bhambhani S, Zutshi V, Sachdeva P. Visual inspection of the cervix with acetic acid for cervical intraepithelial lesions. Int J Gynecol Obstet 2005;88(1):25-30. [DOI:10.1016/j.ijgo.2004.09.018] [PMID]
21. Durdi GS, Sherigar BY, Dalal AM, Desai BR, Malur PR. Correlation of colposcopy using Reid colposcopic index with histopathology-a prospective study. J Turk Ger Gynecol Assoc 2009;10(4):205. [PMCID]
22. Swati S, Mayurika TS. Correlation of Pap Smear and Colposcopic Findings in Relation to Histopathology in Detection of Premalignant Lesions of Cervix. Int J Contemp Med Res 2020;6(1):89-94. [Google Scholar]
23. Boicea A, Patrascu A, Surlin V, Iliescu D, Schenker M, Chiutu L. Correlations between colposcopy and histologic results from colposcopically directed biopsy in cervical precancerous lesions. Rom J Morphol Embryol 2012;53(3 Suppl):735-41. [Google Scholar]
24. Savitha T, Sapna W. A comparison of pap smear, colposcopy and colposcopy directed biopsy in evaluation of unhealthy cervix. J Evol Med Dent Sci 2015;4(21):3639-48. [DOI:10.14260/jemds/2015/524]
25. Rad FS, Ghaebi M, Zarabadipour S, Bajelan A, Pashazade F, Kalhor M, et al. Comparison of diagnostic methods in detection of squamous cell abnormalities in Iranian women with abnormal pap's smear test and associated demographic and issues. Iran J Pathol 2020;15(2):106. [DOI:10.30699/ijp.2020.114626.2248] [PMID] [PMCID]
26. Barut MU, Kale A, Kuyumcuoğlu U, Bozkurt M, Ağaçayak E, Özekinci S, et al. Analysis of sensitivity, specificity, and positive and negative predictive values of smear and colposcopy in diagnosis of premalignant and malignant cervical lesions. Med Sci Monit 2015;21:3860. [DOI:10.12659/MSM.895227] [PMID] [PMCID]
27. Zamani M, Torabian S. Evaluation the colposcopic and histologic findings in oncology ward of Fatemieh hospital, Hamadan, Iran. Iran J Obstet Gynecol Infertil 2013;16(78):1-6. [Google Scholar]
28. Pleş L, Radosa J-C, Sima R-M, Chicea R, Olaru O-G, Poenaru M-O. The Accuracy of Cytology, Colposcopy and Pathology in Evaluating Precancerous Cervical Lesions. Diagnostics 2022;12(8):1947. [DOI:10.3390/diagnostics12081947] [PMID] [PMCID]
29. Bifulco G, De Rosa N, Lavitola G, Piccoli R, Bertrando A, Natella V, et al. A prospective randomized study on limits of colposcopy and histology: the skill of colposcopist and colposcopy-guided biopsy in diagnosis of cervical intraepithelial lesions. Infect Agents Cancer 2015;10(1):1-8. [DOI:10.1186/s13027-015-0042-9] [PMID] [PMCID]
30. Vallikad E, Siddartha PT, Kulkarni KA, Firtion C, Keswarpu P, Vajinepalli P, et al. Intra and Inter-Observer Variability of Transformation Zone Assessment in Colposcopy: A Qualitative and Quantitative Study. J Clin Diagn Res 2017;11(1):XC04. [DOI:10.7860/JCDR/2017/21943.9168] [PMID] [PMCID]

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