Volume 33, Issue 7 (October 2022)                   Studies in Medical Sciences 2022, 33(7): 495-510 | Back to browse issues page

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URL: http://umj.umsu.ac.ir/article-1-5847-en.html
Assistant Professor, Department of Pediatrics, Urmia University of Medical Sciences, Urmia, Iran (Corresponding Author) , hamidrezahoushmand1347@gmail.com
Abstract:   (1513 Views)
Background & Aims: Atopic dermatitis (AD) is the most common inflammatory disease of the epidermis. In this study, we examined the frequency of factors affecting the incidence and clinical manifestations of atopic dermatitis.
Materials & Methods: In this descriptive-analytic study, all children under 5 years old referred to the allergy clinic of Motahhari Hospital in Urmia were examined. To diagnose the disease, standard criteria of Hanifin-Rajka in the form of a 25-item questionnaire were used. The obtained data were analyzed by using (SPSS) software.
Results: In this study, 106 patients with atopic dermatitis (69 males and 37 females) with a mean age of 14.13 ±11.64 months were studied. 49 patients (46.2%) were less and 57 patients (53.8%) are more than one-year-old. Countries of atopic dermatitis were 1.4%. Flexor surface involvement was significantly higher in males than females (P= 0.004). Involvement of flexor levels in patients over 1 year of age was significantly higher than patients under 1 year of age (P= 0.006). Personal or family atopy sample was significantly higher in the patients under 1 year of age than patients over 1 year of age (P=0.005). Itching during sweating was significantly higher in males than females (P =0.016). Danny Morgan line was significantly higher in patients under 1 year than patients over 1 year (P = 0.001). Food intolerance (P=0.016) and skin infections (P = 0.047) were significantly higher in patients over 1 year of age than patients under 1 year of age.
Conclusion: Since we are not able to change some of the risk factors related to the pathogenesis of atopic dermatitis, it is better to focus on other risk factors that are modifiable. This approach can be effective in preventing atopic dermatitis.
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Type of Study: Research | Subject: آسم و آلرژی کودکان

1. Kim KH. Overview of atopic dermatitis. Asia Pac Allergy 2013;3:79-87. [DOI:10.5415/apallergy.2013.3.2.79] [PMID] [PMCID]
2. Kawashima M. Quality of life in patients with atopic dermatitis: impact of tacrolimus ointment. Int J Dermatol 2006;45:731-736. [DOI:10.1111/j.1365-4632.2006.02705.x] [PMID]
3. Harper J, Oranje A, Prose NS. Textbook of Pediatric Dermatology: 2-Volume Set: Wiley-Blackwell; 2006. [URL]
4. Wallach D, Coste J, Tilles G, Taïeb A. The first images of atopic dermatitis: an attempt at retrospective diagnosis in dermatology. Elsevier; 2005. [DOI:10.1016/j.jaad.2005.06.045] [PMID]
5. Christophers E, Fölster-Holst R. Atopic dermatitis versus infantile eczema. J Am Acad Dermatol 2001;45:S2-S3. [DOI:10.1067/mjd.2001.117028] [PMID]
6. Firooz A, Davoudi SM, Farahmand AN, Majdzadeh R, Kashani MN, Dowlati Y. Validation of the diagnostic criteria for atopic dermatitis. Arch Dermatol 1999;135:514-6. [DOI:10.1001/archderm.135.5.514] [PMID]
7. HCADIBS FP, Breathnach S, COXN GC. Rookś Textbook of Dermatology eds. UK. Blackwell Suence Ltd. 2004;18:1-18. [URL]
8. Illi S, von Mutius E, Lau S, Nickel R, Grüber C, Niggemann B, et al. The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol 2004;113:925-31. [DOI:10.1016/j.jaci.2004.01.778] [PMID]
9. Kamer B, Pasowska R, Dółka E, Blomberg A, Rotsztejn H. Prevalence of atopic dermatitis in infants during the first six months of life: authors' observations. Postepy Dermatol Alergol 2013;30:277-81. [DOI:10.5114/pdia.2013.38355] [PMID] [PMCID]
10. Yadav A, Naidu R. Clinical manifestation and sensitization of allergic children from Malaysia. Asia Pac Allergy 2015;5:78-83. [DOI:10.5415/apallergy.2015.5.2.78] [PMID] [PMCID]
11. Kelleher M, Dunn-Galvin A, Hourihane JOB, Murray D, Campbell LE, McLean WI, et al. Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year. J Allergy Clin Immunol 2015;135:930-5. [DOI:10.1016/j.jaci.2014.12.013] [PMID] [PMCID]
12. Van Bever HP, Samuel ST, Lee BW. Halting the allergic march. World Allergy Organ J 2008;1:57-62. [DOI:10.1097/WOX.0b013e31816ddbc1] [PMID] [PMCID]
13. Hanifin JM. Evolving concepts of pathogenesis in atopic dermatitis and other eczemas. J Invest Dermatol 2009;129:320-2. [DOI:10.1038/jid.2008.252] [PMID]
14. Stabell Benn C, Wohlfahrt J, Aaby P, Westergaard T, Benfeldt E, Fleischer Michaelsen K, et al. Breastfeeding and risk of atopic dermatitis, by parental history of allergy, during the first 18 months of life. Am J Epidemiol 2004;160:217-23. [DOI:10.1093/aje/kwh208] [PMID]
15. Bührer C, Grimmer I, Niggemann B, Obladen M. Low 1-year prevalence of atopic eczema in very low birthweight infants. Lancet 1999;353:1674. [DOI:10.1016/S0140-6736(98)03975-0] [PMID]
16. Lucas A, Brooke O, Cole T, Morley R, Bamford M. Food and drug reactions, wheezing, and eczema in preterm infants. Arch Dis Child 1990;65:411-5. [DOI:10.1136/adc.65.4.411] [PMID] [PMCID]
17. Thomsen SF. Atopic dermatitis: natural history, diagnosis, and treatment. ISRN Allergy 2014;2014:354250. [DOI:10.1155/2014/354250] [PMID] [PMCID]
18. Pugliarello S, Cozzi A, Gisondi P, Girolomoni G. Phenotypes of atopic dermatitis. J Dtsch Dermatol Ges 2011;9:12-20. https://doi.org/10.1111/j.1610-0387.2010.07508.x [DOI:10.1111/j.1610-0387.2010.07508_suppl.x] [PMID]
19. Rotsztejn H, Frankowska J, Kamer B, Trznadel-Grodzka E. Infection cases in infants and small children with atopic dermatitis-own observations. Postepy Hig Med Dosw 2012;66:96-103. [Google Scholar]
20. Bussmann C, Peng W-M, Bieber T, Novak N. Molecular pathogenesis and clinical implications of eczema herpeticum. Expert Rev Mol Med 2008;10:e21. [DOI:10.1017/S1462399408000756] [PMID]
21. Qeille-Roussel C, Raynaud F, Saurat J. Aprospective computerized study of 500 cases of atopic dermatitis in childhood. Acta Derm Venereol Suppl 1985;114:87-92. [Google Scholar]
22. Lapidus CS, Schwarz DF, Honig PJ. Atopic dermatitis in children: who cares? Who pays? J Am Acad Dermatol 1993;28:699-703. [DOI:10.1016/0190-9622(93)70096-C] [PMID]
23. Herd R, Tidman M, Prescott R, Hunter J. The cost of atopic eczema. Br J Dermat 1996;135:20-3. https://doi.org/10.1111/j.1365-2133.1996.tb03601.x [DOI:10.1046/j.1365-2133.1996.d01-970.x]
24. Fisher DA. Adverse effects of topical corticosteroid use. West J Med 1995;162:123. [PMCID]
25. Arellano FM, Wentworth CE, Arana A, Fernández C, Paul CF. Risk of lymphoma following exposure to calcineurin inhibitors and topical steroids in patients with atopic dermatitis. J Invest Dermatol 2007;127:808-16. [DOI:10.1038/sj.jid.5700622] [PMID]
26. Ahanchian H, Jafari S, Jabbari F, Kianifar H, Karimi N, Khakshur A, et al. Evaluation of common allergens in children with atopic dermatitis by skin prick test. J North Khorasan Uni Med Sci 2013;5:551-5. [DOI:10.29252/jnkums.5.3.551]
27. Ghaderi R, Tabiee S, Peyrovi S, Jafari Pour M. Prevalence of atopic dermatitis and its risk factors in 2-5 years old children at kindergartens of Birjand city (2008). J Birjand Uni Med Sci 2012;19:286-93. [Google Scholar]
28. Mousavi Z, Samadzadeh D. Evaluation of prevalence of atopic dermatitis among 7-11 year-old primary school boys and girls in Ahvaz. J Yazd Shahid Sadoughi Uni Med Sci 2006;14:38-44. [URL]
29. Afshari f, khadivi r, shirzad h. Risk factors of Atopic dermatitis in Shahrekord schoolchildren. J Shahrekord Univ Med Sci 2006;8:71-75. [URL]
30. Lai CK, Beasley R, Crane J, Foliaki S, Shah J, Weiland S, et al. Global variation in the prevalence and severity of asthma symptoms: phase three of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 2009;64:476-483. [DOI:10.1136/thx.2008.106609] [PMID]
31. Ellwood P, Asher M, Beasley R, Clayton T, Stewart A, Committee IS. The International Study of Asthma and Allergies in Childhood (ISAAC): phase three rationale and methods [research methods]. Int J Tuberc Lung Dis 2005;9:10-6. [Google Scholar]
32. Munivrana H, Vorko-Jovic A, Munivrana S, Kursar M, Medlobi-Gluhak M, Vlahek P. The prevalence of allergic diseases among Croatian school children according to the ISAAC Phase One questionnaire. Med Sci Monit 2007;13:CR505-CR509. [Google Scholar]
33. Simpson EL, Hanifin JM. Atopic dermatitis. J Am Acad Dermatol 2005;53:115-28. [DOI:10.1016/j.jaad.2005.01.130] [PMID]
34. Larsen FS, Diepgen T, Svensson Å. The occurrence of atopic dermatitis in north Europe: an international questionnaire study. J Am Acad Dermatol 1996;34:760-4. [DOI:10.1016/S0190-9622(96)90009-2] [PMID]
35. Marks R, Simons MJ. Geographic tongue-a manifestation of atopy. Br J Dermatol 1979;101:159-62. [DOI:10.1111/j.1365-2133.1979.tb05601.x] [PMID]
36. Böhme M, Svensson Å, Kull I, Wahlgren C-F. Hanifin's and Rajka's minor criteria for atopic dermatitis: which do 2-year-olds exhibit? J Am Acad Dermatol 2000;43:785-92. [DOI:10.1067/mjd.2000.110070] [PMID]
37. Lee HJ, Cho SH, Ha SJ, Ahn WK, Park YM, Byun DG, et al. Minor cutaneous features of atopic dermatitis in South Korea. Int J Dermatol 2000;39:337-42. [DOI:10.1046/j.1365-4362.2000.00958.x] [PMID]
38. Williams HC. Epidemiology of atopic dermatitis. Clin Exp Dermatol 2000;25:522-9. [DOI:10.1046/j.1365-2230.2000.00698.x] [PMID]

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