Volume 33, Issue 3 (June 2022)                   Studies in Medical Sciences 2022, 33(3): 152-159 | Back to browse issues page

Ethics code: IR.UMSU.REC.1400.049

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URL: http://umj.umsu.ac.ir/article-1-5805-en.html
Professor of Anesthesiology, Urmia University of Medical Sciences, Urmia, Iran (Corresponding Author) , AminValizade@gmail.com
Abstract:   (786 Views)
Background & Aims: Colorectal cancer is one of the most common cancers and one of the leading cause of morbidity and mortality worldwide. Accounting that the risk of colorectal cancer is associated with blood sugar indices as well as the role of CEA in the prognosis of patients with colorectal cancer, this study was fulfilled to determine the relationship between serum level of CEA and HOMA2-IR in colorectal patients.
Materials & Methods: In this case-control study, 40 colorectal cancer patients and 40 healthy subjects, as the control group, were included. Serum levels of CEA, insulin, and fasting blood sugar were measured in all participants. The HOMA2-IR index was calculated based on the standard formula. Data were analyzed using SPSS version 26 software.
Results: The mean of CEA was 7.08±1.9 in colorectal patients and 2.21±1.5 in control group, and difference between them was significant (p = 0.003). Totally, the mean insulin among patients with CEA below 3 and CEA equal or more than 3 was 11.06±6.9 and 14.34±8.28, respectively (p = 0.026). Also, mean FBS for two groups were 110.67±42.7 and 135.9±52.5 (p = 0.01) and mean of HOMA2-IR for two groups were 1.49±0.98 and 2.04±1.25, (P = 0.011), respectively. All these differences between two groups were significant.
Conclusion: colorectal patients had higher levels of CEA than the control group. The mean values of all three indices of insulin, FBS و and HOMA2-IR among patients with colorectal cancer were higher in both groups of patients with CEA below 3 and patients with CEA equal or more than 3 than control group. There was strong positive correlations between CEA with insulin, FBS, and HOMA2-IR indices in colorectal patients compared to the control group.
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Type of Study: Research | Subject: جراحی عمومی

1. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015;136(5):E359-E86. [DOI:10.1002/ijc.29210] [PMID]
2. Cronin KA, Lake AJ, Scott S, Sherman RL, Noone AM, Howlader N, et al. Annual Report to the Nation on the Status of Cancer, part I: National cancer statistics. Cancer 2018;124(13):2785-800. [DOI:10.1002/cncr.31551] [PMID] [PMCID]
3. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin 205-29: (1) 65;15. [DOI:10.3322/caac.21254] [PMID]
4. Yeh M, Oh CS, Yoo JY, Kaur B, Lee TJ. Pivotal role of microRNA-138 in human cancers. Am J Cancer Res 2019;9(6):1118. [PMCID]
5. Weinberg BA, Marshall JL, Salem ME. The growing challenge of young adults with colorectal cancer. Oncology 2017;31(5):381-9. [Google Scholar]
6. Brody H. Colorectal cancer. Nature 521. S1, https://doi org/101038/521S1a. 2015. [DOI:10.1038/521S1a] [PMID]
7. Giovannucci E, Harlan DM, Archer MC, Bergenstal RM, Gapstur SM, Habel LA, et al. Diabetes and cancer: a consensus report. CA Cancer J Clin 2010;60(4):207-21. [DOI:10.3322/caac.20078] [PMID]
8. Ishino K, Mutoh M, Totsuka Y, Nakagama H. Metabolic syndrome: a novel high-risk state for colorectal cancer. Cancer Lett 2013;334(1):56-61. [DOI:10.1016/j.canlet.2012.10.012] [PMID]
9. Jee SH, Yun JE, Park EJ, Cho ER, Park IS, Sull JW, et al. Body mass index and cancer risk in Korean men and women. Int J Cancer 2008;123(8):1892-6. [DOI:10.1002/ijc.23719] [PMID]
10. Holdenrieder S. Biomarkers along the continuum of care in lung cancer. Scand J Clin Lab Invest Suppl 2016;76(sup245):S40-S5. [DOI:10.1080/00365513.2016.1208446] [PMID]
11. Tomita M, Ayabe T, Chosa E, Nose N, Nakamura K. Prognostic significance of a tumor marker index based on preoperative serum carcinoembryonic antigen and Krebs von den Lungen-6 levels in non-small cell lung cancer. Asian Pac J Cancer Prev 2017;18(1):287. [Google Scholar]
12. Polat E, Duman U, Duman M, Atici A, Reyhan E, Dalgic T, et al. Diagnostic value of preoperative serum carcinoembryonic antigen and carbohydrate antigen 19-9 in colorectal cancer. Curr Oncol 2014;21(1):1-7. [DOI:10.3747/co.21.1711] [PMID] [PMCID]
13. Mittal A, Farooqui SM, Pyrtuh S, Poudel B, Sathian B, Yadav SK. Efficacy of carcinogenic embryonic antigen in differential diagnosis of diseases of pancreas and liver-A comparative study in a tertiary care hospital of western Nepal. Asian Pac J Cancer Prev 2012;13(1):275-7. [DOI:10.7314/APJCP.2012.13.1.275] [PMID]
14. Oliveira CLd, Mello MTd, Cintra IdP, Fisberg M. Obesity and metabolic syndrome in infancy and adolescence. Rev de Nutr 2004;17(2):237-45. [DOI:10.1590/S1415-52732004000200010]
15. McKeown-Eyssen G. Epidemiology of colorectal cancer revisited: are serum triglycerides and/or plasma glucose associated with risk? Cancer Epidemiol Biomark Prev 1994;3(8):687-95. [Google Scholar]
16. Giovannucci E. Insulin and colon cancer. Cancer Causes Control 1995;6(2):164-79. [DOI:10.1007/BF00052777] [PMID]
17. Giouleme O, Diamantidis MD, Katsaros MG. Is diabetes a causal agent for colorectal cancer? Pathophysiological and molecular mechanisms. World J Gastroenterol 2011;17(4):444. [DOI:10.3748/wjg.v17.i4.444] [PMID] [PMCID]
18. Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MB, et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 2000;23(1):57-63. [DOI:10.2337/diacare.23.1.57] [PMID]
19. Vulcan A, Manjer J, Ohlsson B. High blood glucose levels are associated with higher risk of colon cancer in men: a cohort study. BMC Cancer 2017;17(1):1-8. [DOI:10.1186/s12885-017-3874-4] [PMID] [PMCID]
20. Limburg PJ, Stolzenberg-Solomon RZ, Vierkant RA, Roberts K, Sellers TA, Taylor PR, et al. Insulin, glucose, insulin resistance, and incident colorectal cancer in male smokers. Clin Gastroenterol Hepatol 2006;4(12):1514-21. [DOI:10.1016/j.cgh.2006.09.014] [PMID] [PMCID]
21. Park H, Cho S, Woo H, Park SK, Shin H-R, Chang S-H, et al. Fasting glucose and risk of colorectal cancer in the Korean Multi-center Cancer Cohort. PloS One 2017;12(11):e0188465. [DOI:10.1371/journal.pone.0188465] [PMID] [PMCID]
22. Shin H-Y, Jung KJ, Linton JA, Jee SH. Association between fasting serum glucose levels and incidence of colorectal cancer in Korean men: the Korean Cancer Prevention Study-II. Metabolism 2014;63(10):1250-6. [DOI:10.1016/j.metabol.2014.07.006] [PMID]
23. Xu J, Ye Y, Wu H, Duerksen-Hughes P, Zhang H, Li P, et al. Association between markers of glucose metabolism and risk of colorectal cancer. BMJ Open 2016;6(6):e011430. [DOI:10.1136/bmjopen-2016-011430] [PMID] [PMCID]
24. Lu J, Wang H, Zhang X, Yu X. HbA1c is positively associated with serum carcinoembryonic antigen (CEA) in patients with diabetes: a cross-sectional study. Diabetes Therap 2018;9(1):209-17. [DOI:10.1007/s13300-017-0356-2] [PMID] [PMCID]
25. Onitilo AA, Berg RL, Engel JM, Glurich I, Stankowski RV, Williams G, et al. Increased risk of colon cancer in men in the pre-diabetes phase. PloS One 2013;8(8):e70426. [DOI:10.1371/journal.pone.0070426] [PMID] [PMCID]
26. Primrose JN, Perera R, Gray A, Rose P, Fuller A, Corkhill A, et al. Effect of 3 to 5 years of scheduled CEA and CT follow-up to detect recurrence of colorectal cancer: the FACS randomized clinical trial. Jama 2014;311(3):263-70. [DOI:10.1001/jama.2013.285718] [PMID]
27. Su B-B, Shi H, Wan J. Role of serum carcinoembryonic antigen in the detection of colorectal cancer before and after surgical resection. World J Gastroenterol 2012;18(17):2121. [DOI:10.3748/wjg.v18.i17.2121] [PMID] [PMCID]
28. Baqar AR, Wilkins S, Staples M, Lee CHA, Oliva K, McMurrick P. The role of preoperative CEA in the management of colorectal cancer: A cohort study from two cancer centres. Int J Surg 2019;64:10-5. [DOI:10.1016/j.ijsu.2019.02.014] [PMID]
29. Yoon YS, Keum N, Zhang X, Cho E, Giovannucci EL. Hyperinsulinemia, insulin resistance and colorectal adenomas: a meta-analysis. Metabolism 2015;64(10):1324-33. [DOI:10.1016/j.metabol.2015.06.013] [PMID]
30. Ortiz AP, Thompson CL, Chak A, Berger NA, Li L. Insulin resistance, central obesity, and risk of colorectal adenomas. Cancer2012;118(7):1774-81. [DOI:10.1002/cncr.26454] [PMID] [PMCID]
31. Jia J, Li M, Teng W, Wang L, Zang W, Xiao J, et al. Prognostic Significance of Preoperative Serum Carcinoembryonic Antigen Varies with Lymph Node Metastasis Status in Colorectal Cancer. J Oncol 2021;2021. [] [PMID] [PMCID]
32. Park IJ, Choi G-S, Lim KH, Kang BM, Jun SH. Serum carcinoembryonic antigen monitoring after curative resection for colorectal cancer: clinical significance of the preoperative level. Ann Surg Oncol 2009;16(11):3087-93. [DOI:10.1245/s10434-009-0625-z] [PMID]
33. Liu JJ, Druta M, Shibata D, Coppola D, Boler I, Elahi A, et al. Metabolic syndrome and colorectal cancer: is hyperinsulinemia/insulin receptor-mediated angiogenesis a critical process? J Geriatr Oncol 2014;5(1):40-8. [DOI:10.1016/j.jgo.2013.11.004] [PMID] [PMCID]
34. Muc-Wierzgoń M, Nowakowska-Zajdel E, Dzięgielewska-Gęsiak S, Kokot T, Klakla K, Fatyga E, et al. Specific metabolic biomarkers as risk and prognostic factors in colorectal cancer. World J Gastroenterol 2014;20(29):9759. [] [PMID] [PMCID]
35. Sun L, MingjieXu M, Wang L, Wang Y, Wang Y. Increase of carcinoembryonic antigen level in serum is associated with metabolic factors and lifestyle. Int J New Tech Res 2016;2(4): 263544. [DOI:10.1186/s40364-016-0065-4] [PMID] [PMCID]
36. Chung S, Lee Y, Roh EY. HbA1c showed a positive association with carcinoembryonic antigen (CEA) level in only diabetes, not prediabetic or normal individuals. J Clin Lab Anal 2019;33(6):e22900. [DOI:10.1002/jcla.22900]
37. No J-I, Yang J-Y, Hyun HJ, Yeon CS, Choi H-J. Factors associated with serum levels of carcinoembryonic antigen in healthy non-smokers. Korean J Fam Med 2013;34:413(6). [] [PMID] [PMCID]
38. Hasan M, Mohieldein A. Association between serum carcinoembryonic antigen level and oxidative stress parameters among diabetic females. Int J Clin Exp Med 2015; 6489:8(4). [PMCID]

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