Volume 32, Issue 6 (September 2021)
Studies in Medical Sciences 2021, 32(6): 458-467 |
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seyedmardani S, Aghdashi M A, Aryanezhad S, Ayremlou P. DEMOGRAPHIC AND CLINICAL FEATURES OF TAKAYASU ARTERITIS IN WEST AZERBAIJAN, IRAN: 2010-2018. Studies in Medical Sciences 2021; 32 (6) :458-467
URL: http://umj.umsu.ac.ir/article-1-5447-en.html
URL: http://umj.umsu.ac.ir/article-1-5447-en.html
Assistant Professor of Rheumatology, Department of Internal Medicine, School of Medicine Urmia University of Medical Sciences, Urmia, Iran (Corresponding Author) , Mardani.m@umsu.ac.ir
Abstract: (1930 Views)
Background & Aims: Takayasu arteritis is a chronic disease of medium- and large-sized arteries. Its clinical diversity in different geographical areas can be due to the involvement of different vascular regions. In this cross-sectional study, we aimed to evaluate the clinical presentations, and demographic and radiologic findings of patients with Takayasu arteritis who were admitted to Urmia University Hospital in 2010 – 2018.
Materials & Methods: Data of the patients with Takayasu arthritis (presence of at least three criteria of American College of Rheumatology), including their constitutional, neuro-vascular, cardio-vascular symptoms were collected from their medical files. Data were analyzed using SPSS 20 software.
Results: In this study, we evaluated 14 patients (12 females – 2 males). The mean diagnosis age was 33.00 ± 9.16 years and the mean delay in diagnosis was 5.11±4.99 years. All patients )100% (presented ischemic complication. It was reported that 78.6% of cases had a decrease in brachial pulse and 64.3% had a difference in blood pressure between arms. Limb claudication and subclavian bruit were 78.6% and 71.4%, respectively. According to angiographic findings, most of patients had stenosis (78.6%) and type IIa (42.9%). The pure aneurysmal lesion was not reported in any of the patients. In only one patient (7.1%), with type IV, intestinal ischemia resulted in death.
Conclusion: Takayasu arteritis occurs most commonly in young women with a diversity of manifestations. In the early stages of the disease, nonspecific clinical and laboratory findings lead to delayed diagnosis and irreversible ischemic lesion. These complications highlight the necessity of careful vascular examinations.
Materials & Methods: Data of the patients with Takayasu arthritis (presence of at least three criteria of American College of Rheumatology), including their constitutional, neuro-vascular, cardio-vascular symptoms were collected from their medical files. Data were analyzed using SPSS 20 software.
Results: In this study, we evaluated 14 patients (12 females – 2 males). The mean diagnosis age was 33.00 ± 9.16 years and the mean delay in diagnosis was 5.11±4.99 years. All patients )100% (presented ischemic complication. It was reported that 78.6% of cases had a decrease in brachial pulse and 64.3% had a difference in blood pressure between arms. Limb claudication and subclavian bruit were 78.6% and 71.4%, respectively. According to angiographic findings, most of patients had stenosis (78.6%) and type IIa (42.9%). The pure aneurysmal lesion was not reported in any of the patients. In only one patient (7.1%), with type IV, intestinal ischemia resulted in death.
Conclusion: Takayasu arteritis occurs most commonly in young women with a diversity of manifestations. In the early stages of the disease, nonspecific clinical and laboratory findings lead to delayed diagnosis and irreversible ischemic lesion. These complications highlight the necessity of careful vascular examinations.
Keywords: Takayasu arteritis, vasculitis, clinical manifestations, demographic characteristics, angiographic finding
Type of Study: Research |
Subject:
روماتولوژی
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