Volume 32, Issue 2 (May 2021)                   Studies in Medical Sciences 2021, 32(2): 105-115 | Back to browse issues page

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Khatami M, haji seyed javadi A, esmaeeli N. ADHERENCE TO MEDICATION IN PATIENTS WITH BIPOLAR 1 DISORDER VISITING PSYCHIATRIC CENTERS AFFILIATED WITH QAZVIN UNIVERSITY OF MEDICAL SCIENCES IN 2017. Studies in Medical Sciences 2021; 32 (2) :105-115
URL: http://umj.umsu.ac.ir/article-1-5276-en.html
Psychiatrist, Qazvin University of Medical Sciences, Qazvin, Iran (Corresponding Author) , M916K@YAHOO.COM
Abstract:   (2003 Views)
Background & Aims: Bipolar disorder or manic depression is a psychiatric disease of the mood disorder type. The estimated prevalence of bipolar 1 disorder is ~1% in a person’s lifetime. Failure to adhere to medications is a concern for psychiatrists. The present study aimed to examine adherence to medication in patients with bipolar 1 disorder visiting psychiatric centers affiliated with Qazvin University of Medical Sciences in 2017.
Materials & Methods: This cross-sectional study was conducted in Qazvin, Iran, in 2017. The sample comprised of 80 patients with bipolar 1 disorder in whom the diagnosis was made by psychiatrists based on DSM-5 classification. Participants were selected via convenience sampling and based on inclusion criteria. After collecting demographic and clinical information, the patients were evaluated using the Morisky Medication Adherence Scale and the Young Mania Rating Scale. All data were analyzed in SPSS 21.
Results: Qualitative data resulting from the evaluations were reported as frequency and percentage, while quantitative data were expressed in mean and standard deviation. The frequency of qualitative variables was compared across groups using the chi-squared test, and the quantitative variables were compared using the t-test at p<0.05.
Conclusion: Considering the necessity and importance of drug treatment in the treatment of this disorder, which was mentioned from different approaches, the aim of this study was to determine drug adherence in patients with bipolar I disorder and the factors affecting it. In the present study, adherence to medication was not significantly related to sex, age, level of education, occupation, number of hospitalizations, and type and side-effects of medications. However, it negatively correlated with the number of visits to the emergency department, i.e. As the adherence to medication decreased, the number of visits to the emergency department increased.
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Type of Study: Research | Subject: روانپزشکی

References
1. Sadock BJ. Synopsis of psychiatry. 8th Ed: Wiring as a Dock; 2009. p. 1527-31. [URL]
2. Sadock BJ. Comprehensive Text Book of Psychiatry. Wiring As a dock; 2009. p. 1575-81. [URL]
3. de Sousa RT, Zarate Jr CA, Zanetti MV, Costa AC, Talib LL, Gattaz WF, et al. Oxidative stress in early stage bipolar disorder and the association with response to lithium. J Psychiatr Res2014;50:36-41. [DOI:10.1016/j.jpsychires.2013.11.011] [PMID] [PMCID]
4. Wittchen HU, Jacobi F, Rehm J, Gustavsson A, Svensson M, Jönsson B, Olesen J, Allgulander C, Alonso J, Faravelli C, Fratiglioni L. The size and burden of mental disorders and other disorders of the brain in Europe 2010. Eur Neuropsychopharmacol 2011;21(9):655-79. [DOI:10.1016/j.euroneuro.2011.07.018] [PMID]
5. Dean BB, Gerner D, Gerner RH. A systematic review evaluating health-related quality of life, work impairment, and healthcare costs and utilization in bipolar disorder. Curr Med Res Opin 2004;20(2):139-54. [DOI:10.1185/030079903125002801] [PMID]
6. Chen MH, Su TP, Chen YS, Hsu JW, Huang KL, Chang WH, Chen TJ, Bai YM. Higher risk of developing major depression and bipolar disorder in later life among adolescents with asthma: a nationwide prospective study. J Psychiatr Res 2014;49:25-30. February 2014;49:25-30. [DOI:10.1016/j.jpsychires.2013.10.015] [PMID]
7. Aydin A, Selvi Y, Besiroglu L, Boysan M, Atli A, Ozdemir O, Kilic S, Balaharoglu R. Mood and metabolic consequences of sleep deprivation as a potential endophenotype'in bipolar disorder. J Affect Disord 2013;150(2):284-94. [DOI:10.1016/j.jad.2013.04.007] [PMID]
8. Rezaei Taf. Statistical Diagnostic Guide to Mental Disorders.20, editor. American Psychiatric Association DSM5: Honorable Publications;2014. P. 172. [URL]
9. Fletcher K, Parker G, Bayes A, Paterson A, McClure G. Emotion regulation strategies in bipolar II disorder and borderline personality disorder: differences and relationships with perceived parental style. J Affect Disord 2014;157:52-9. [DOI:10.1016/j.jad.2014.01.001] [PMID]
10. Balanzá-Martínez V, Selva G, Martínez-Arán A, Prickaerts J, Salazar J, González-Pinto A, et al. Neurocognition in bipolar disorders-a closer look at comorbidities and medications. Eur J Pharmacol 2010;626(1):87-96. [DOI:10.1016/j.ejphar.2009.10.018] [PMID]
11. Hori H, Yamamoto N, Teraishi T, Ota M, Fujii T, Sasayama D, et al. Cognitive effects of the ANK3 risk variants in patients with bipolar disorder and healthy individuals. J Affect Disord2014;158:90-6. [DOI:10.1016/j.jad.2014.02.008] [PMID]
12. Fulford D, Peckham AD, Johnson K, Johnson SL. Emotion perception and quality of life in bipolar I disorder. J Affect Disord 2014;152:491-7. [DOI:10.1016/j.jad.2013.08.034] [PMID] [PMCID]
13. Aydin A, Selvi Y, Besiroglu L, Boysan M, Atli A, Ozdemir O, et al. Mood and metabolic consequences of sleep deprivation as a potential endophenotype'in bipolar disorder. J Affect Disord 2013;150(2):284-94. [DOI:10.1016/j.jad.2013.04.007] [PMID]
14. Qalabandi Faq. Clinical Psychiatric Mood Disorders. Tehran: Farhang Sazan Publications; 1379.. 110.
15. P. SBSVR. Comprehensive Textbook of Psychiatry2017. [Google Scholar]
16. Simpson SH, Eurich DT, Majumdar SR, Padwal RS, Tsuyuki RT, Varney J, et al. A meta-analysis of the association between adherence to drug therapy and mortality. Bmj 2006;333(7557):15. [DOI:10.1136/bmj.38875.675486.55] [PMID] [PMCID]
17. Montes JM, Maurino J, de Dios C, Medina E. Suboptimal treatment adherence in bipolar disorder: impact on clinical outcomes and functioning. Patient Prefer Adherence 2013;7:89. [DOI:10.2147/PPA.S39290] [PMID] [PMCID]
18. Gonzalez‐Pinto A, Mosquera F, Alonso M, López P, Ramírez F, Vieta E, et al. Suicidal risk in bipolar I disorder patients and adherence to long‐term lithium treatment. Bipolar Disord 2006;8(5p2):618-24. [DOI:10.1111/j.1399-5618.2006.00368.x] [PMID]
19. Mallik Greene LP, Teresa Lemmer, Alexandra Piedade, Maelys Touya, and Otavio Clark. Systematic literature review on patterns of pharmacological treatment and adherence among patients with bipolar disorder type I. Neuropsychiatr Dis Treat2018;14: 1545-59. [DOI:10.2147/NDT.S166730] [PMID] [PMCID]
20. Jawad I, Watson S, Haddad PM, Talbot PS, McAllister-Williams RH. Medication nonadherence in bipolar disorder: a narrative review. Ther Adv Psychopharmacol2018;8(12):349-63. [DOI:10.1177/2045125318804364] [PMID] [PMCID]
21. Ertem M, Duman ZÇ. Motivational interviewing in a patient with schizophrenia to achieve treatment collaboration: A case study. Arch Psychiatr Nurs 2016;30(2):150-4. [DOI:10.1016/j.apnu.2015.08.003] [PMID]
22. Moharamzad Y SH, Nakhjavan Shahraki B, Rai A, Saadat Z, Aerab-Sheibani H, Naghizadeh MM, Morisky DE. Validation of the Persian Version of the 8-Item Morisky Medication Adherence Scale (MMAS-8) in Iranian Hypertensive Patients. Glob J Health Sci 2015:173-83. [DOI:10.5539/gjhs.v7n4p173] [PMID] [PMCID]
23. Copeland LA, Zeber JE, Salloum IM, Pincus HA, Fine MJ, Kilbourne AM. Treatment Adherence and Illness Insight in Veterans With Bipolar Disorder. J Nerv Ment Dis 2008;196(1):16-21. [DOI:10.1097/NMD.0b013e318160ea00] [PMID]
24. Martha Sajatovic DIV, Peter J.Weiden, Marcia A.Valenstein, Gbenga Ogedegbe. Measurement of psychiatric treatment adherence. J Psychosom Res 2010;69(6):591-9. [DOI:10.1016/j.jpsychores.2009.05.007] [PMID] [PMCID]
25. Lukasiewicz M, Gerard S, Besnard A, Falissard B, Perrin E, Sapin H, et al.The emblem study group. Young Mania Rating Scale: how to interpret the numbers? Determination of a severity threshold and of the minimal clinically significant difference in the EMBLEM cohort. I Int J Methods Psychiatr Res 2013;22(1):46-58. [DOI:10.1002/mpr.1379] [PMID] [PMCID]
26. Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 1978;133:429-35. [DOI:10.1192/bjp.133.5.429] [PMID]
27. Baraktin Majid Tam, Mawlawi Hussein, Mohsen's famous, Salehi Mehrdad. Standardization, validity and validity of Yang Mania Scale. Journal of Psychology. 1386; 11 (2): 166-50..
28. Azadforouz S, Shabani A, Nohesara S, Ahmadzad-Asl M. Non-compliance and related factors in patients with bipolar I disorder: A six month follow-up study. Iran J Psychiatry Behav Sci 2016;10(2):e2448. [DOI:10.17795/ijpbs-2448] [PMID] [PMCID]
29. Sharifi A, Shabani A, Ahmadzadasl. The pattern of adherence in patients with bipolar I disorder; an eight weeks study.Iran J Psychiatry Behav Sci 2009; 3(2): 39-43. [Google Scholar]
30. Tavakoli M. Validity and reliability of Yong mania rating scale. (Dissertation). Isfahan University; 2005. []
31. Berk M, Malhi GS, Cahill C, Carman AC, Hadzi‐Pavlovic D, Hawkins MT, et al. The Bipolar Depression Rating Scale (BDRS): its development, validation and utility. Bipolar Disord 2007;9(6):571-9. [DOI:10.1111/j.1399-5618.2007.00536.x] [PMID]
32. Ebrahimi A, Barekatain M, Bornamanesh A, Nassiri H. Psychometric properties of the Persian version of Bipolar Depression Rating Scale (BDRS) in patients and general population. Iran J Psychiatry Clin Psychol 2015;21(1):60-8. [URL]
33. Sajatovic M, Biswas K, Kilbourne AK, Fenn H, Williford W, Bauer MS. Factors associated with prospective long-term treatment adherence among individuals with bipolar disorder. Psychiatr Serv 2008;59(7):753-9. [DOI:10.1176/ps.2008.59.7.753] [PMID]
34. Small size Samqazfar. Risk factors in recurrence of type 1 bipolar disorder and its relationship with demographic characteristics. Journal of Tabriz University of Medical Sciences. 1388; 31 (168): 174-2. [URL]
35. S Kattimani KS, S Sarkar, Rajkumar RP, Balasubramanian S. History of lifetime suicide attempt in bipolar I disorder: its correlates and effect on illness course. J Psychiatry Clin Pract 2017;21(2):118-124. [DOI:10.1080/13651501.2016.1250912] [PMID]
36. Sajatovic M, Blow FC, Kales HC, Valenstein M, Ganoczy D, Ignacio RV.Age comparison of treatment adherence with antipsychotic medications among individuals with bipolar disorder. Int J Geriatr Psychiatry 2007;22(10):992-8. [DOI:10.1002/gps.1777] [PMID]
37. Sajatovic M, Ignacio RV, West JA, Cassidy KA, Safavi R, Kilbourne AM, et al. Predictors of nonadherence among individuals with bipolar disorder receiving treatment in a community mental health clinic. Compr Psychiatry 2009;50(2):100-7. [DOI:10.1016/j.comppsych.2008.06.008] [PMID] [PMCID]
38. Morisky DE, Ang A, Krousel-Wood M, Ward HJ. Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens (Greenwich) 2008;10(5):348-54. [DOI:10.1111/j.1751-7176.2008.07572.x] [PMID] [PMCID]

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