Volume 22, Number 2 (biomonthly 2011)                   J Urmia Univ Med Sci 2011, 22(2): 85-91 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

bagheri M, Abdi rad I, omrani M, nanbakhsh F. THE 4G/5G GENETIC VARIATION IN THE PROMOTER OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) GENE IN PATIENTS WITH RECURRENT MISCARRIAGE AND HEALTHY CONTROLS. J Urmia Univ Med Sci. 2011; 22 (2) :85-91
URL: http://umj.umsu.ac.ir/article-1-909-en.html

instructor , Urmia University of Medical Sciences , mortazabagheri@yahoo.com
Abstract:   (14663 Views)

Background & Aims: Deletion/insertion of a single guanosine in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene, resulting in two alleles containing either 4 or 5 guanosines (G). Results of recent studies showed that presence of PAI-1 4G allele may increase the risk of human disease.  The aim of present study was to determine the 4G/5G genetic variation in the promoter of PAI-1 gene in patients with recurrent miscarriage and healthy controls.

Materials and Methods: Genotypes of 45 cases with recurrent miscarriage (at least 3 unexplained abortions) and 64 controls were determined by RFLP-PCR.

Results:  The findings of present study shows: Frequency (percent) of PAI-1 4G allele in cases and controls were 29(32.22%) and47(36.72%), respectively frequency (percent) of PAI-1 5G allele in cases and controls were 61(67.78%) and 81(63.28%),  respectively. Frequency (percent) of PAI-1 5G/5G and 4G/4G was 16(35.56%) and 29(64.44%) in cases and 17(26.56%) and 47(73.44%) in controls, respectively. PAI-1 4G/4G genotype was not observed in studied groups. Statistical analysis showed that the frequencies of PAI-1 -675 4G/5G alleles and genotypes did not   significantly differ between cases and controls.

Conclusion: The findings of present study show that it is not possible to find any association between PAI-1 -675 4G allele and predisposition to recurrent miscarriage in tested population.  

Source: Urmia Med J 2011: 22(2):165 ISSN: 1027-3727

 

 

Full-Text [PDF 1804 kb]   (1105 Downloads)    
Type of Study: Research | Subject: آناتومی
Received: 2011/05/14

Add your comments about this article : Your username or email:
Write the security code in the box

Send email to the article author


© 2015 All Rights Reserved | URMIA MEDICAL JOURNAL

Designed & Developed by : Yektaweb