Volume 21, Number 4 (Dec-Nov Biomonthly 2010)                   J Urmia Univ Med Sci 2010, 21(4): 339-346 | Back to browse issues page


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Dastgiri S, Bonyadi M, Mizani T. THE PREVALENCE OF GENETIC DISORDERS IN EAST AZERBAIJAN PROVINCE. J Urmia Univ Med Sci. 2010; 21 (4) :339-346
URL: http://umj.umsu.ac.ir/article-1-787-en.html

Associate Professor of Epidemiology , saeed.dastgiri@gmail.com
Abstract:   (11799 Views)

  Received: 11 Oct, 2010 Accepted: 3 Nov, 2010

  Abstract

  Background & Aims : Genetic disorders are responsible for a major proportion of mortality, morbidity, and handicap in the world varying by racial, ethnicity and cultural differences. The aim of this study was to estimate the prevalence of genetic disorders in East Azerbaijan.
Materials & Methods: In this descriptive cross sectional study, 2968 cases (53% males and 47% females) with confirmed genetic disorders or carriers of the traits diagnosed by molecular methods were investigated. Sex, area/place of residence of patients, and reporting year were identified. The prevalence rate, descriptive statistics, and a 95% confidence interval were used for data analysis.

  Results : The study subjects were: patients (n=1312), carriers (n=1474), suspected cases (n=157), and unknown cases (n=25). The most prevalent (in five years) disorders were identified as familial Mediterranean fever (20.58 in 100000), inherited deafness (11.37 in 100000), spinal-muscular atrophy (11.12 in 100000), cystic fibrosis (7.98 in 100000), Duchenne muscular dystrophy (7.84 in 100000), and down syndrome (5.09 in 100000).

  Conclusion : Estimating the true prevalence of the genetic disorders helps in planning health care and screening programs. The prevalence of these diseases in the region indicates the necessity to establish a population-based center for genetic disorders. More population-based investigations are however needed to develop effective preventive strategies to control genetic disorders in the region.

 

 

 

  Source: Urmia Med J 2010: 21(4): 377 ISSN: 1027-3727

Full-Text [PDF 226 kb]   (1239 Downloads)    
Type of Study: Research | Subject: آناتومی
Received: 2010/12/13

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