Volume 33, Issue 1 (April 2022)                   Studies in Medical Sciences 2022, 33(1): 8-18 | Back to browse issues page

Research code: 398281
Ethics code: IR.MUI.MED.REC.1398.447
Clinical trials code: IRCT20130311012782N54


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Moradi Farsani D, Shetabi H, Aboutalebi E. THE PROPHYLACTIC EFFECT OF INTRAVENOUS INJECTION OF MAGNESIUM SULFATE AND PARACETAMOL AND THEIR COMBINATION ON PAIN INTENSITY AFTER DEEP VITRECTOMY. Studies in Medical Sciences 2022; 33 (1) :8-18
URL: http://umj.umsu.ac.ir/article-1-5645-en.html
Associate Professor, Department of Anesthesiology, Isfahan University of Medical Sciences, Isfahan, Iran (corresponding author) , dmoradi@med.mui.ac.ir
Abstract:   (1335 Views)
Background & Aims: Due to the high prevalence and importance of postoperative pain and opioid complications, we aimed to compare the prophylactic effect of intravenous injection of magnesium sulfate and paracetamol and their combination on pain intensity after deep vitrectomy in this study.
Materials & Methods: In this clinical trial study, 140 candidates of deep vitrectomy randomly distributed in four groups of 35. in the first group, 7.5 mg/kg magnesium sulfate was injected 20 minutes before the operation. In the second group, 15 mg/kg paracetamol, in the third group 10 mg/kg paracetamol plus 5 mg/kg magnesium sulfate within ten minutes, and in the fourth group, normal saline with the same volume was injected. The patients were then examined and compared in terms of hemodynamic parameters, pain intensity, amount of palliatives consumed, frequency of receiving palliatives, and occurrence of postoperative complications.
 Results: The mean postoperative pain intensity in the four groups of magnesium sulfate, paracetamol, magnesium sulfate-paracetamol, and control were 1.32 ± 0.9, 1.42 ± 0.34, 1.05 ± 0.38, and 1.72 ± 0.95, respectively, and the difference between the groups was significant (P = 0.003). The number of patients received pethidine were significantly lower in the combination group than the other groups (P = 0.018). The time interval between entering recovery and receiving analgesia in the group was significantly longer in the combination group than the other groups (P <0.001).
Conclusion: The use of magnesium sulfate-paracetamol combination reduces the postoperative pain intensity, prolongs the time of requesting analgesia, and reduces the use of analgesia within 24 hours after surgery, without any significant hemodynamic complication.
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Type of Study: Clinical trials | Subject: Anesthesia

References
1. Writing DRCRN. Vitrectomy outcomes in eyes with diabetic macular edema and vitreomacular traction. Ophthalmology 2010;117(6):1087-93. [DOI:10.1016/j.ophtha.2009.10.040] [PMID] [PMCID]
2. Gao X, Ikuno Y, Fujimoto S, Nishida K. Risk factors for development of full-thickness macular holes after pars plana vitrectomy for myopic foveoschisis. Am J Ophthalmol 2013;155(6):1021-7. [DOI:10.1016/j.ajo.2013.01.023] [PMID]
3. Kalra P. Miller's Anesthesia, Volumes 1 and 2. J Am Soc Anesthesiol 2010;112(1):260. [DOI:10.1097/ALN.0b013e3181c5dc06]
4. De Oliveira Jr GS, Castro-Alves LJ, McCarthy RJ. Single-dose systemic acetaminophen to prevent postoperative pain: a meta-analysis of randomized controlled trials. Clin J Pain 2015;31(1):86-93. [DOI:10.1097/AJP.0000000000000081] [PMID]
5. Dionne R. Preemptive Vs. preventive analgesia: which approach improves clinical outcomes? Compend Contin Educ Dent 2006; 21(1):48-56 [Google Scholar]
6. Taheri A, Haryalchi K, Ghanaie M, and Habibi N. Effect of Low-Dose (Single-Dose) Magnesium Sulfate on Postoperative Analgesia in Hysterectomy Patients Receiving Balanced General Anesthesia. Anesthesiol Res Pract 2015: 306145. [DOI:10.1155/2015/306145] [PMID] [PMCID]
7. Graham GG, Davies MJ, Day RO, Mohamudally A, Scott KF. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Inflammopharmacology 2013;21(3):201-32. [DOI:10.1007/s10787-013-0172-x] [PMID]
8. Alipour M, Tabari M, Alipour M. Paracetamol, ondansetron, granisetron, magnesium sulfate and lidocaine and reduced propofol injection pain. Iranian Red Crescent Med J 2014;16(3):e16086. [DOI:10.5812/ircmj.16086]
9. Kalani N, Sanie MS, Zabetian H, Radmehr M, Sahraei R, Jahromi HK, Marzouni HZ. Comparison of the analgesic effect of paracetamol and magnesium sulfate during surgeries. World J Plast Surg 2016;5(3):280. [] [PMCID]
10. Hamed MA, Al-Saeed MA. The Efficacy of Intravenous Magnesium Sulfate versus Intravenous Paracetamol on Children Posttonsillectomy Pain and Analgesic Requirement: A Randomized Controlled Study. Anesth Essays Res 2018;12(3):724-8. [DOI:10.4103/aer.AER_113_18] [PMID] [PMCID]
11. Heydari SM, Hashemi SJ, Pourali S. The comparison of preventive analgesic effects of ketamine, paracetamol and magnesium sulfate on postoperative pain control in patients undergoing lower limb surgery: a randomized clinical trial. Advanced biomedical research. 2017;6:1-7. [DOI:10.4103/2277-9175.217217] [PMID] [PMCID]
12. Mirkheshti AR, Aryani MR, Dabbagh A, Jabbary-moghaddam M, Razavi SS, Elyasi H, Mohammadi-tofigh A. Comparison of Magnesium Sulfate and Paracetamol in Analgesic Effect and Venous Blood Gas Alterations during Intravenous Regional Anesthesia with Lidocaine. Anesth Pain 2011;2(3):27-37 [Google Scholar]
13. Amany SA,Khaled MM.Dose the addition of magnesium to bupivacaine improve postoperative analgesia of ultrasound-guided thoracic paravertebral block in patients undergoing thoracic surgery. J Anesth 2014; 28:58-63 [DOI:10.1007/s00540-013-1659-8] [PMID]
14. Khalili G, Janghorbani M, Sajedi P, Ahmadi G. Effects of adjunct intrathecal magnesium sulfate to bupivacaine for spinal anesthesia: A randomized double-blind trial in patients undergoing lower extremity surgery. J Anesth 2011;25:892-7 [DOI:10.1007/s00540-011-1227-z] [PMID]
15. Jabalameli M,Pakzadmoghadam S H. Adding different doses of intrathecal magnesium sulfate for spinal anesthesia in the cesarean section: A prospective double blind randomized trial. Adv Biomed Res.2012;1:7 [DOI:10.4103/2277-9175.94430] [PMID] [PMCID]
16. Charu JP, Shivang CJ, Jignesh PM. Acomparative study of bupivacaine and bupivacaine with magnesium sulphate in spinal anesthesia for lower abdominal surgry. Int J Sci Res 2013;2(7):276-8 [DOI:10.15373/22778179/JULY2013/91]
17. Adinehmehr L, Shetabi H, Moradi Farsani D, Salehi A, Noorbakhsh M. Comparison of the Sedation Quality of Etomidate, Propofol, and Midazolam in Combination with Fentanyl During Phacoemulsification Cataract Surgery: A Double-Blind, Randomized, Controlled, Clinical Trial. Anesth Pain Med 2019;9(2):e87415. [DOI:10.5812/aapm.87415] [PMID] [PMCID]
18. Moradi Farsani D, Naghibi Kh,Alikiaei B, Mashayekhi Z.Comparison of the Effects of Intravenous Phenylephrine and Ephedrine in Treatment of Hypotension after Spinal Anesthesia in Orthopedic Surgery. J Babol Univ Med Sci 2016;18(6):21-7. [Google Scholar]
19. Aghadavoudi O, Shetabi H, Dezfouli ZS. Comparison of the Analgesic and Sedative Effects of Midazolam-Ketamine and Propofol-Sufentanil Combinations in Painful Procedures of Children with Haematologic Malignancy. Turk J Anaesthesiol Reanim 2020;48(2):120-6. [DOI:10.5152/TJAR.2019.42402] [PMID] [PMCID]
20. Moradi-Farsani D, Azamian-Jazi Z, Heydari SM, Nazemroaya B. The Effect of Subcutaneous Injection of Metoclopramide, Pethidine,and Ketamine on Postoperative Pain after Inguinal Hernia Repair under General Anesthesia. J Isfahan Med Sch 2020;38(572):252-9. [Google Scholar]
21. Abbasi S, Talakoub R, Jahangirifard B, Masoodifar M and Saryazdi H. Bispectral index response to cricoid pressure during induction of general anesthesia J Isfahan Univ Med Sci 2011;16(1):63. [PMCID]

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