Volume 31, Issue 3 (June 2020)
Studies in Medical Sciences 2020, 31(3): 199-208 |
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Boyerahmadi A, Tadibi V, Hosseinpour Delavar S, Behpour N. EFFECT OF AEROBIC TRAINING ON THE FUNCTION OF HEPATIC SODIUM-DEPENDENT ASCORBATE TRANSPORTER TYPE 2 AND SERUM LEVELS OF HEPATIC TRANSAMINASES IN HEALTHY AND DIABETIC WISTAR RATS: INTERVENTIONAL AND EXPERIMENTAL STUDY. Studies in Medical Sciences 2020; 31 (3) :199-208
URL: http://umj.umsu.ac.ir/article-1-5048-en.html
URL: http://umj.umsu.ac.ir/article-1-5048-en.html
Associate Professor, Department of Exercise Physiology, School of Sports Sciences, Razi University, Kermanshah, Iran. (Corresponding Author) , sport.tadibi@gmail.com
Abstract: (2465 Views)
Background & Aims: Sodium-dependent ascorbate transporter 2 (SVCT2) plays a key role in the transmission of ascorbic acid to hepatocytes. The aim of this study was to compare the effect of aerobic training on hepatic SVCT2 levels, serum levels of alanine aminotransferase (ALT), and aspartate aminotransferase (AST) in diabetic rats.
Materials & Methods: In this interventional and experimental study, 25 male Wistar rats were randomly divided into 5 groups: 1) healthy control, 2) healthy training, 3) diabetes control, 4) diabetes training, and 5) sham. After Induction of diabetes, training program consisted of 6 weeks of running on the treadmill, 5 sessions per week (for 20-40 minutes). Serum and liver tissues were evaluated to investigate the effect of exercise training on ascorbic acid metabolism.
Results: Induction of diabetes significantly decreased serum and hepatic ascorbic acid levels and significantly increased hepatic SVCT2 protein, ALT and AST serum levels (p <0.001). The results also showed that regular aerobic exercise decreased serum glucose levels, serum levels of ALT and AST but had no significant effect on serum hepatic and ascorbic acid levels and hepatic SVCT2.
Conclusion: According to the results of this study, induction of diabetes reduces hepatic ascorbic acid levels, which seems to be associated with hyperglycemia and liver injury. On the other hand, six weeks of aerobic exercise reduced blood glucose and liver transaminases, but had no significant effect on level of serum, hepatic ascorbic acid, and hepatic SVCT2 levels.
Materials & Methods: In this interventional and experimental study, 25 male Wistar rats were randomly divided into 5 groups: 1) healthy control, 2) healthy training, 3) diabetes control, 4) diabetes training, and 5) sham. After Induction of diabetes, training program consisted of 6 weeks of running on the treadmill, 5 sessions per week (for 20-40 minutes). Serum and liver tissues were evaluated to investigate the effect of exercise training on ascorbic acid metabolism.
Results: Induction of diabetes significantly decreased serum and hepatic ascorbic acid levels and significantly increased hepatic SVCT2 protein, ALT and AST serum levels (p <0.001). The results also showed that regular aerobic exercise decreased serum glucose levels, serum levels of ALT and AST but had no significant effect on serum hepatic and ascorbic acid levels and hepatic SVCT2.
Conclusion: According to the results of this study, induction of diabetes reduces hepatic ascorbic acid levels, which seems to be associated with hyperglycemia and liver injury. On the other hand, six weeks of aerobic exercise reduced blood glucose and liver transaminases, but had no significant effect on level of serum, hepatic ascorbic acid, and hepatic SVCT2 levels.
Keywords: Diabetes, Liver, Aerobic training, Sodium-dependent ascorbate transporter 2, Liver transaminases, Ascorbic acid
Type of Study: Research |
Subject:
Exercise physiology
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