Volume 26, Issue 11 (Monthly_feb 2016)                   Stud Med Sci 2016, 26(11): 984-992 | Back to browse issues page

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KhademVatani K, Khadem-Ansari M H, Oloofi S, Shakibi A, Rostamzadeh A, Askari6 B, et al . SURVEY OF CORRELATION BETWEEN SERUM CERULOPLASMIN LEVEL AND CORONARY ARTERY DISEASE. Stud Med Sci. 2016; 26 (11) :984-992
URL: http://umj.umsu.ac.ir/article-1-3220-en.html
Cardiology Department, Fellowship in Interventional Cardiology , Faculty of Medicine, Urmia University ofMedical Sciences, Urmia, Iran , : hmohammadzad@gmail.com):(E-mail
Abstract:   (5062 Views)

Background & Aims:Over the last decade, cardiovascular disease (CVD) has become the single largest cause of death worldwide including all developing regions. The coronary artery disease (CAD) is the most lethal form of CVD. Ceruloplasmin is a ferroxidase enzyme with two paradoxically oxidative and antioxidative performances. Some studies show that ceruloplasmin give rise to atherosclerosis by oxidative effect on low density lipoprotein (LDL).

Materials & Methods: This study was done in Urmia Seyed-ol Shohada Hospital. The serum levels of ceruloplasmin were measured in 43 consecutive CAD patients (more than 75% stenosis at least in one coronary arteries by selective coronary angiography) and 43 consecutive control subjects (normal epicardial coronary arteries by selective coronary angiography). Exclusion criteria were lymphoma, pregnancy, oral contraceptive drugs, rheumatoid arthritis, Alzheimer's disease, heart failure (LVEF<40%), diabetes mellitus, heavy smokers, obsessive  disorders, schizophrenia, dyslipidemia, and hypertension. CAD patients and normal group   were matched for hypertension and dyslipidemia.

Results: There wasn’t significant statistical difference in serum ceruloplasmin level between CAD patients (298±115mg/L) and control subjects (281±81mg/L).There wasn’t significant gender difference in serum ceruloplasmin level.

Conclusion: The result of the present study doesn’t support the hypothesis that a high serum ceruloplasmin level is a risk factor for coronary artery disease. If we exclude major CAD risk factors and effective factors on serum ceruloplasmin level, it can be stated that a high serum ceruloplasmin level is not an independent risk factor for atherosclerotic CAD.

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Type of Study: Research | Subject: قلب و عروق

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