Received: 9 Apr , 2013 Accepted: 9 Jun
, 2013
Abstract
Background & Aims: Post-operative shivering is
very common and it is usually followed by many problems such as an increase in oxygen
consumption, blood pressure, intracranial and intraocular pressure, and post-operation
pain. Therefore, it is very important to prevent shivering especially in the elderly
and ischemic heart disease patients. The goal of this study was comparing the
effect of Pethidine (Meperidine), Dexamethasone, and Placebo in prevention of
shivering.
Materials & Methods: This double blind
clinical trial study was carried out on 120 patients who were candidates for
surgery under general anesthesia.The patients were randomly
divided into three groups including those who received placebo (a) Dexamethasone
(b) and Pethidine (c). Induction and maintenance of anesthesia for all patients
were similar. Central and peripheral temperature of patients was measured every 5 minute interval. After induction saline normal, Dexamethasone
and Pethidine were respectively injected to groups a, b, and c. In
recovery, all patients were controlled for visible shivering: The data were
statistically analyzed by SPSS software and ANOVA and chi square tests.
Results: There were no significant differences
among three mentioned groups regarding of gender, age, duration of surgery, and
recovery time. Nineteen cases (47.5%) in
group a had post-operative shivering. Whereas, in group b only 4 cases (10%) had shivering and the
difference between 2 groups was significant (P value = 0.001). Also in group c,
15 cases (37.5%) had shivering that the difference with placebo group was significant
(P value = 0.08).
Conclusion: The present study showed that pethidine
and dexamethasone are effective drugs for preventing post-operative shivering
in elective surgery. And the effect of dexamethasone in preventing the post-operative
shivering is better than Pethidine. Dexamethasone can be
administered after induction of anesthesia as an alternative to administration
of Pethidine (as a common method of prevention and treatment of postoperative
shivering) particularly in patients with hemodynamic instability.
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