Volume 33, Issue 12 (March 2023)                   Studies in Medical Sciences 2023, 33(12): 868-875 | Back to browse issues page

Ethics code: IR.IAU.PIAU.REC.1401.002


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Moayeri M, Nezhadali M, Mohamadi M. ASSOCIATION BETWEEN FAT MASS AND OBESITY ASSOCIATED (FTO) RS17817449 GENE POLYMORPHISM WITH INSULIN RESISTANCE AND OBESITY IN THE PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE. Studies in Medical Sciences 2023; 33 (12) :868-875
URL: http://umj.umsu.ac.ir/article-1-5903-en.html
Department of Biology, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran , moayeri110@gmail.com
Abstract:   (994 Views)
Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is now the most common liver disease that affects a quarter of global population. NAFLD is associated with metabolic disorders such as type 2 diabetes, high blood pressure, obesity, and cardiovascular diseases. The aim of this study was to investigate the association of FTO (fat mass and obesity associated) rs17817449 gene polymorphism with insulin resistance and obesity in the people with NAFLD.
Materials & Methods: This case-control study was conducted on 80 patients with non-alcoholic fatty liver disease and 80 participants as controls. Insulin concentration was measured by ELISA kit and the other variables were determined by standard methods. Genotyping was done by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLPmethod. Data were analyzed using SPSS version 20 software at significance level below 0.05.
Results: The results showed that all the variables except LDL, fasting plasma glucose (FPG) and cholesterol had significant association between control and NAFLD group (P<0.05). However, no associations were found between rs17817449 polymorphism with Body Mass Index and HOMA, and genotype frequencies of rs17817449 was not significantly different between obese and normal subjects, as well as between insulin-resistant and insulin-sensitive groups (P>0.05).
Conclusion: Nonalcoholic fatty liver disease is associated with Body Mass Index and insulin resistance. The FTO rs17817449 polymorphism is not associated with obesity and insulin resistance.
Full-Text [PDF 442 kb]   (690 Downloads)    
Type of Study: Research | Subject: بیوشیمی

References
1. Angulo P, Lindor KD. Non-alcoholic fatty liver disease. J Gastroenterol Hepatol 2002;17:186-90. [DOI:10.1046/j.1440-1746.17.s1.10.x] [PMID]
2. Kumar R, Priyadarshi RN, Anand U. Non-alcoholic fatty liver disease: growing burden, adverse outcomes and associations. J Clin Transl Hepatol 2020;8(1):76-86. [DOI:10.14218/JCTH.2019.00051] [PMID] [PMCID]
3. Lee SS, Park SH. Radiologic evaluation of nonalcoholic fatty liver disease. World J gastroenterol 2014; 20(23):7392-402. [DOI:10.3748/wjg.v20.i23.7392] [PMID] [PMCID]
4. Hashemi M, Hanafi bijd H, Eskandari nasab E, Hashemzehi NA, Shafieipour S, Narouie B, Bahari A, et al. Association of adiponectin rs 1501299and rs266729 Gene Polymorphisms With Nonalcoholic Fatty Liver Disease. Hepat Mon 2013;13(5):e9527. [DOI:10.5812/hepatmon.9527]
5. Chen X, Gao Y, Yang X, Zhang H, Mo Z, Tan A. Relationship of FTO gene variations with NAFLD risk in Chinese men. Open Life Sci 2020;15:860-7. [DOI:10.1515/biol-2020-0081] [PMID] [PMCID]
6. Xu A, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest 2003;112(1):91-100. [DOI:10.1172/JCI200317797] [PMID] [PMCID]
7. Pandey AK, Jalihal U, Pramila MN, Gowda V MN, Vinay MD, Prabhu VMD. Estimation of adiponectin levels in diabetic, non-diabetic fatty liver diseases and healthy controlsInternational. Int J Res Med Sci 2015;3(1):140-6. [DOI:10.5455/2320-6012.ijrms20150124]
8. Zhang CX, Guo LK, Qin YM, Li GY. Interaction of Polymorphisms of Resistin Gene Promoter-420C/G, Glutathione Peroxidase -1 Gene Pro198Leu and Cigarette Smoking in Nonalcoholic Fatty Liver Disease. Chin Med J 2015;128(18):2467-73. [DOI:10.4103/0366-6999.164931] [PMID] [PMCID]
9. Namakin K, Hosseini M, Zardast M, Mohammadifard M. Prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD)and its Clinical Characteristics in Over weight and Obese Children in the SouthEast of Iran. Hepat Mon 2018;18(12):e83525. [DOI:10.5812/hepatmon.83525]
10. Sohouli M, Lari A. The Association between Polyphenols Intake and Odds of Non-Alcoholic Fatty Liver Disease (NAFLD) among Adult Population. Int J Nutr Sci 2020;5(3):122-9. [Google Scholar]
11. Cha SW, Choi SM, Kim KS, Park BL, Kim JR, Kim JY, e al. Replication of genetic effects of FTO polymorphisms on BMI in a Korean population. Obesity 2008;16:2187-9. [DOI:10.1038/oby.2008.314] [PMID]
12. Dyson JK, Anstee QM, McPherson S. Non-alcoholic fatty liver disease: a practical approach to treatment. Frontline Gastroenterol 2014;5(4):277-86. [DOI:10.1136/flgastro-2013-100404] [PMID] [PMCID]
13. Li H, Wu Y, Loos RJ, Hu FB, Liu Y, Wang J, Yu Z, Lin X. Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. Diabetes 2008;57(1):264-8. [DOI:10.2337/db07-1130] [PMID]
14. Abdelmajed SS, Youssef M, Zaki ME, Hassan NA, Ismail S. Association analysis of FTO gene polymorphisms and obesity risk among Egyptian children and adolescents. Genes & Dis 2017;4(3):170-5. [DOI:10.1016/j.gendis.2017.06.002] [PMID] [PMCID]
15. Bakhashab S, Batarfi AA, Filimban N, Bajouh OS, Dallol A, Alqahtani MH. Polycystic ovary syndrome is linked with the fat mass obesity (FTO) gene variants rs17817449 and rs1421085 in western Saudi Arabia. Bioinformation 2021;30;17(11):904-10. [DOI:10.6026/97320630017904] [PMID] [PMCID]
16. Barseem NF, El Ella SSA, Tawfik MA, El-Nehrawy RR. The Potential Implication of FTO rs17817449 Gene Polymorphism on BMI Mediated Risk for Type2 Diabetes Among Obese Egyptian Children and Adolescents. Endocr Metab Immune Disord Drug Targets 2019;19(5):697-704. [DOI:10.2174/1871530319666190101124751] [PMID]
17. Prakash J, Srivastava N, Awasthi S, Agarwal CG, Natu SM, Rajpal N, et al. Association of FTO rs17817449 SNP with obesity and associated physiological parameters in a north Indian population. Ann Hum Biol 2011;38(6):760-3. [DOI:10.3109/03014460.2011.614278] [PMID]
18. Do R, Bailey SD, Desbiens K, Belisle A, Montpetit A, Bouchard C, et al. Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study. Diabetes 2008;57(4):1147-50. [DOI:10.2337/db07-1267] [PMID]
19. Fall T, Hägg S, Mägi R, Ploner A, Fischer K, Horikoshi M, et al. The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis. PLoS Med 2013;10(6): e1001474. [Google Scholar]
20. Guo J, Ren W, Li X, Xi G, Li Y, Gao L. Altering of FTO in the serum and livers of NAFLD patients: a correlation analysis. Int J Clin Exp 2018; 6046-53. [Google Scholar]
21. Ahmad T, Lee IM, Paré G, Chasman DI, Rose L, Ridker PM, Mora S. Lifestyle Interaction with Fat Mass and Obesity-Associated (FTO) Genotype and Risk of Obesity in Apparently Healthy U.S. Women. Diabetes Care 2011;34:675-80. [DOI:10.2337/dc10-0948] [PMID] [PMCID]
22. Song DK, Lee H, Oh JY, Hong YS, Sung YA. FTO Gene Variants Are Associated with PCOS Susceptibility and Hyperandrogenemia in Young Korean Women. Diabetes Metab J 2014;38(4):302-10. [DOI:10.4093/dmj.2014.38.4.302] [PMID] [PMCID]

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Studies in Medical Sciences

Designed & Developed by : Yektaweb