Volume 31, Issue 8 (November 2020)                   Studies in Medical Sciences 2020, 31(8): 635-642 | Back to browse issues page

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Mirzaei Z, Khashabi E, Mirzaei L. EVALUATION OF THE CLINICAL EFFECTS OF THE CURCUMIN PACK ON REDUCING BLEEDING AND SWELLING AFTER THIRD MOLAR SURGERY COMPARED TO THE ROUTINE PACKS: RANDOMIZED DOUBLE–BLIND EXPERIMENTAL. Studies in Medical Sciences 2020; 31 (8) :635-642
URL: http://umj.umsu.ac.ir/article-1-4669-en.html
Assistant Professor, Dental and Periodontal Research Center, Faculty of Dentistry, University of Medical Sciences, Urmia, Iran (Corresponding Author) , khashabi.e@yahoo.com
Abstract:   (2375 Views)
Background & Aims: One of the most common causes of the jaw and facial surgery is the third molar called wisdom teeth. Since the presence of swelling and bleeding after extraction of these teeth especially in the mandible is one of the common problems in the patients, we decided to investigate the therapeutic and common effects of the patients. So, we investigated the effects of the cream impregnated with curcumin material on reducing bleeding and also the rate of swelling in patients whose third molar teeth were surgically treated.
Materials & Methods: The experimental study was a randomized double-blinded study using observation technique.48 male and female patients referring to the private clinic were randomly divided into two groups of patients using turmeric powder impregnated as a control group and sterile packaged treatment group. Then, both groups were measured for bleeding in two times: immediately after the removal of the pack (10 minutes later); and half an hour after the removal of the pack. The presence of swelling after surgery was evaluated using the packs and the findings were compared in groups.
Results: Comparison of swelling with the Mann-Whitney test and Wilcoxon signed-rank test showed that z was-3.428 and the p-value was0.001.So the curcumin pack was effective in reducing swelling; however, the results of these tests for bleeding time showed that z was0.292 and p-value was 0.77. In other words, curcumin was not effective in reducing bleeding.
Conclusion: The findings of this study showed that treatment with curcumin impregnated pack was not effective in reducing bleeding while dataturmeric powder impregnated was more effective in reducing swelling for the third molars surgery.
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References
1. Tetsch P, Wagner W. Operative extraction of wisdom teeth. 6th Ed. Wolf Medical Publications Ltd, London1990;Chap5:158-69.
2. Tucker MR, Hupp JR, Ellis E. Contemporary oral and maxillofacial surgery. 5th Ed. St. Louis, Mo.: Mosby Elsevier; 2008. p.198. [URL]
3. Haghighat A, Kaviani N, Mosharrafifar M. Evaluation of celecoxib effect in reducing oral ibuprofen after third molar surgery. J Isfahan Dent Sch 2005; 2(1): 29-33. [Google Scholar]
4. Katzung BG. Basic and clinical pharmacology. 4th ed. London, UK: Appleton & Lange; 1989. p. 635-48. [URL]
5. Grossi GB, Maiorana C, Garramone RA, Borgonovo A, Creminelli L, Santoro F. Assessing postoperative discomfort after third molar surgery: a prospective study. J Oral Maxillofac Surg 2007; 65(5): 901-17. [DOI:10.1016/j.joms.2005.12.046] [PMID]
6. Arteagoitia I, Diez A, Barbier L, Santamaria G, Santamaria J. Efficacy of amoxicillin/clavulanic acid in preventing infectious and inflammatory complications following impacted mandibular third molar extraction. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;100:11-8. [DOI:10.1016/j.tripleo.2005.03.025] [PMID]
7. Rundgren M, Engstrom M. A thromboelastometric evaluation of the effect of hypothermia on the coagulation system. J Anesth Analg 2008:107:1465-68. [DOI:10.1213/ane.0b013e31817ee955] [PMID]
8. Ozmeric N, Mollaoglu N, Elgun S, Devrim E. Impact of chlorhexidine mouth rinse use on postextraction infection via nitric oxide pathway. Inflamm Res 2010; 59(6): 437-41. [DOI:10.1007/s00011-009-0115-6] [PMID]
9. Venkatesh Babu NS, Vivek DK, Ambika G. Comparative evaluation of chlorhexidine mouthrinse versus cacao bean husk extract mouthrinse as antimicrobial agents in children. Eur Arch Paediatr Dent 2011; 12(5): 245-9. [DOI:10.1007/BF03262816] [PMID]
10. Ghorbani Z, Hekmatdoost A, Mirmiran P. Anti-Hyperglycemic and Insulin Sensitizer Effects of Turmeric and Its Principle Constituent Curcumin. Int J Endocrinol Metab 2014; 12: e. 18081. [DOI:10.5812/ijem.18081] [PMID] [PMCID]
11. Gupta SC, Sung B, Kim JH, Prasad S, Li S, Aggarwal BB. Multitargeting by turmeric, the golden spice: From kitchen to clinic. Mol Nutr Food Res 2013; 1510: 28-57. [DOI:10.1002/mnfr.201100741] [PMID]
12. Hasani-Ranjbar S, Larijani B, Abdollahi M. A systematic review of the potential herbal sources of future drugs effective in oxidant-related diseases. Inflamm Allergy Drug Targets 2009; 8(1): 2-10 [DOI:10.2174/187152809787582561] [PMID]
13. Aggarwal BB, Sundaram C, Malani N, Ichikawa H. Curcumin: the Indian solid gold. Adv Exp Med Biol 2007;595:1-75. [DOI:10.1007/978-0-387-46401-5_1] [PMID]
14. Bhagavathula N, Warner RL, DaSilva M, McClintock SD, Barron A, Aslam MN and et al. A combination of curcumin and ginger extract improves abrasion wound healing in corticosteroid-impaired hairless rat skin. Wound Repair Regen 2009; 360: 6-17 [DOI:10.1111/j.1524-475X.2009.00483.x] [PMID] [PMCID]
15. Kotwal GJ, Curcumin. A Versatile Nutraceutical and an Inhibitor of Complement, in Handbook of Nutraceuticals. Pathak Y, Editor. CRC Press: Boca Raton. 2010, pp: 217-220. [DOI:10.1201/9781420082227-c13]
16. Cheppudira B, Fowler M, McGhee L, Greer A, Mares A, Petz L, et al. Curcumin: a novel therapeutic for burn pain and wound healing. Expert Opin Investig Drugs 2013;22(10):1295-303. [DOI:10.1517/13543784.2013.825249] [PMID]
17. Srinivasan K. Plant foods in the management of diabetes mellitus: spices as beneficial antidiabetic food adjuncts. Int J Food Sci Nutr 2005;56(6):399414. [DOI:10.1080/09637480500512872] [PMID]
18. Gupta SC, Kismali G, and Aggarwal BB. Curcumin, a component of turmeric: from farm to pharmacy. Biofactors 2013; 2: 13-39 [DOI:10.1002/biof.1079] [PMID]
19. Tilak JC, Banerjee M, Mohan H and Devasagayam TP. Antioxidant availability of turmeric in relation to its medicinal and culinary uses. Phytother Res 2004; 18: 798-804. [DOI:10.1002/ptr.1553] [PMID]
20. Hupp JR, Ellis E, Tucker MR, Editors. Contemoporary oral and maxilla a facial surgery. 5th ed. New York: Mosby; 2008. p.44-45 [URL]
21. Maradana MR, Thomas R and O'Sullivan BJ. Targeted delivery of curcumin for treating type 2 diabetes. Mol Nutr Food Res 2013; 1550: 6-57. [DOI:10.1002/mnfr.201200791] [PMID]
22. Kaufmann FN, Gazal M, Bastos CR, Kaster MP, Ghisleni G. Curcumin in depressive disorders: An overview of Potential mechanisms, preclinical and clinical findings. Eur J Pharmacol 2016; 784:192-8. [DOI:10.1016/j.ejphar.2016.05.026] [PMID]
23. Yan H, Yuan Y, Xi ZH, Kun ZH, Shaohua CH, Zhiyun D. Curcumin, Inflammation, and Chronic Diseases How Are They Linked? Molecules 2015; 20: 9183-213 [DOI:10.3390/molecules20059183] [PMID] [PMCID]
24. Sanivarapu R, Vallabhaneni V, Verma V. The Potential of Curcumin in Treatment of Spinal Cord Injury. Neurol Res Int 2016; 2016: 9468193. [DOI:10.1155/2016/9468193] [PMID] [PMCID]
25. Akyuz S, Turan F, Gurbuzler L, Arici A, Sogut E, Ozkan O. The Anti-Inflammatory and Antioxidant Effects of Curcumin in Middle Ear Infection. J Craniofac Surg 2016; 27(5): 494-7. [DOI:10.1097/SCS.0000000000002810] [PMID]
26. Heng MC. Wound healing in adult skin: aiming for perfect regeneration. Int J Dermatol 2011; 1058: 50-66. [DOI:10.1111/j.1365-4632.2011.04940.x] [PMID]
27. Grandjean-Laquerriere A, Gangloff SC, Le Naour R, Trentesaux C, Hornebeck W, Guenounou M. Relative contribution of NF-kappaB and AP-1 in the modulation by curcumin and pyrrolidine dithiocarbamate of the UVB-induced cytokine expression by keratinocytes. Cytokine 2002;18(3):168-77. [DOI:10.1006/cyto.2002.0888] [PMID]
28. Ainechi Y, Herbal Materia Medica and Iran. Tehran: Publishing and Printing Institute of Tehran University; 1991.p.20-56.
29. Laureano Filho JR, Maurette PE, Allais M, Cotinho M, Fernandes C. Clinical comparative study of the effectiveness of two dosages of Dexamethasone to control postoperative swelling, trismus and pain after the surgical extraction of mandibular impacted third molars. Med Oral Patol Oral Cir Bucal 2008; 13(2): E129-E132. [Google Scholar]
30. Peterson LJ. Contemporary oral And maxillofacial surgery. 4th ed. Philadelphia, PA: Mosby; 2003. p. 84-220. [URL]
31. Mali A, Behal R, Gilda S. Comparative evaluation of 0.1% turmeric mouthwash with0.2% chlorhexidine gluconate in prevention of plaque and gingivitis: A clinical and microbiological study. J Indian Soc Periodontal 2012; 16(3): 386-91. [DOI:10.4103/0972-124X.100917] [PMID] [PMCID]
32. Kant V, Gopal A, Pathak NN, Kumar P, Tandan SK, Kumar D. Antioxidant and antiinflammatory potential of curcumin accelerated the cutaneouswound healing in streptozotocin-induced diabetic rats. Int Immunopharmacol 2014; 322:20-30. [DOI:10.1016/j.intimp.2014.03.009] [PMID]
33. Brunicardi F, Andersen D, Billiar T, Dunn D, Hunter J, Pollock RE, Editors. Schwartz principles of general surgery. 9th ed. Philadelphia: McGraw-Hill Professional; 2010. p.158-338. [URL]
34. Danda AK, Krishna Tatiparthi M, Narayanan V, Siddareddi A. Influence of primary and secondary closure of surgical wound after impacted mandibular third molar removal on postoperative pain and swelling--a comparative and split mouth study. J Oral Maxillofac Surg 2010;68(2): 309-12. [DOI:10.1016/j.joms.2009.04.060] [PMID]
35. Chandra D, Gupta S. Anti-inflammatory and antiarthritic activity of volatile oil of Curcuma longa (Haldi). Ind J Med Res 1972; 60: 138 - 42. [URL]
36. Cheppudira B, Fowler M, McGhee L, Greer A, Mares A, Petz L, et al. Curcumin: a novel therapeutic for burn pain and wound healing. Expert Opin Investig Drugs 2013;22(10):1295-303. [DOI:10.1517/13543784.2013.825249] [PMID]
37. Jagetia GC, Rajanikant GK. Acceleration of wound repair by curcumin in the excision wound of mice exposed to different doses of fractionated gamma radiation. Int Wound J 2012; 76: 9-92. [DOI:10.1111/j.1742-481X.2011.00848.x] [PMID] [PMCID]
38. Mills S, Bone K. Principle and practice of phytotherapy. 1st ed. London: Churchil; 2000 p. 199. [URL]
39. khosrojerdi A, Mashayekhi K, Zare Marzouni H. Curcumin (Extracted from Tumeric) and its Therapeutic Effects. Jorjani Biomed J. 2016; 4 (2):1-20 [URL]
40. Bayat M, Melkomian L, Roushani Faraahani Z. Evaluation of administration of chlorhexidine rinse and antibiotic in decrease of mandibular third molar post extraction complications. J Dent Sch Shahid Beheshti Univ Med Sci 2007;24(4): 429-34. [Google Scholar]
41. khosrojerdi A, Mashayekhi K, Zare Marzouni H. Curcumin (Extracted from Tumeric) and its Therapeutic Effects. Jorjani Biomedicine Journal 2016; 4 (2):1-20. [URL]
42. Ghorbani Z, Khadem E. Therapeutic Applications of Turmeric and Its Principle Constituent Curcumin in Wound Healing and Skin Regeneration from the Perspective of Conventional Medicine and Iranian Traditional Medicine (ITM). J Med Plants 2017; 16 (64):12-21 [Google Scholar]
43. Gholami Arjenak V, Miandeh Mozhgani, Narges Miandeh HR, Janani AR, Ajorloo M, Zavareh AR,et al. Evaluation of the effect of temperature on bleeding duration after tooth extraction. Research in Medicine 2013; 36 (4):173-5.
44. Naderi G, Dinani NJ, Nejabat N, Kelardasht M, Dehkordi AJ, Asgary S, et al. In vitro fibrinolytic activity by polyphenolic extract of Zataria moltiflora Boiss., Curcuma domestica Valet., Heracleum persicum Desf. Ex Fischer and Cinnamomum verum J. Presl. Iranian Journal of Medicinal and Aromatic Plants 2010;25(4):572-80. [URL]

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