دوره 28، شماره 4 - ( 4-1396 )                   جلد 28 شماره 4 صفحات 64-73 | برگشت به فهرست نسخه ها



DOI: 10.18869/acadpub.umj.28.4.64

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Mahmoodi M, Soleimani Mehranjani M. Stereological Study of the Protective Role of Curcumin on Histological Changes of Seminal Vesicle in Mice Following Treatment with Sodium Arsenite. J Urmia Univ Med Sci. 2017; 28 (4) :64-73
URL: http://umj.umsu.ac.ir/article-1-3823-fa.html
Mahmoodi Monireh، Soleimani Mehranjani Malek. Stereological Study of the Protective Role of Curcumin on Histological Changes of Seminal Vesicle in Mice Following Treatment with Sodium Arsenite. مجله پزشکی ارومیه. 1396; 28 (4) :64-73

URL: http://umj.umsu.ac.ir/article-1-3823-fa.html


Arak University ، m-mahmoodi@araku.ac.ir
چکیده:   (145 مشاهده)
Background & Aims: Sodium arsenite causes oxidative stress and endocrine disorders in the reproductive system. The aim was to investigate the protective role of curcumin as an antioxidant on the seminal vesicle tissue in adult mice treated with sodium arsenite.
Materials & Methods: Adult male Naval Medical Research Institute (NMRI) mice were randomly divided into 5 groups (six mice per group) including control, sham (treated with DMSO), Sodium arsenite (5mg/kg/day b.w.), Curcumin (15mg/kg/day b.w.) and Sodium arsenite + Curcumin. After 5 weeks of treatment, the mice were anesthetized and the seminal vesicles were removed and weighed. This followed by evaluating of the mean total volume of seminal vesicle and the mean volume of parenchyma, vesicular fluid, epithelial cells, vessels, connective and muscular tissues using stereological techniques. The results analyzed statistically by one-way ANOVA and Tukey's test and the means were considered significantly different at p<0.05.
Results: A significant reduction in the mean total volume of seminal vesicle and mean volume of vesicular fluid (p<0.001), and a significant increase in the mean volume of connective tissue (p<0.001) were seen in the sodium arsenite group when compared to the control ones. The mentioned parameters were compensated to the control level in the sodium arsenite + curcumin group.
Conclusion: Our results showed that curcumin could prevent the adverse histological changes induced by sodium arsenite treatment on the seminal vesicle in mice.
واژه‌های کلیدی: Sodium arsenite، Curcumin، Seminal vesicles، Stereology، Mice
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نوع مطالعه: پژوهشي(توصیفی- تحلیلی) | موضوع مقاله: بافت شناسی
دریافت: ۱۳۹۵/۱۱/۱۷ | پذیرش: ۱۳۹۶/۲/۱۶ | انتشار: ۱۳۹۶/۵/۴

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