Dr Hossein Nazari , Nasrin Jahanjo, Mehdi Safarieh, Mehdi Taherian, Ali Khaleghian, Dr Abbasali Vafaei, Dr Ahmadreza Bandegi, Dr Hadi Amrollahi, Dr Abuolfazl Mohamadi,
Volume 22, Issue 5 (Biomonthly Dec-Jan 2011)
Abstract
Background & Aims : Man in all historical periods had to use domestic and medicine herbal plants. Over the last half century, the use of synthetic and chemical drugs is highly prevalent. The harmful effect of chemical drugs on human life has increased the tendency to use medicinal plants once more. The aim of this study was to investigate the effect of Avena sativa active ingredients on the wound healing and skin inflammation on the rat model.
Materials & Methods : Extract of water, methanol and ethanol Avena sativa seeds were prepared by water distillation and Soxhlet systems. The components of all samples were determinate using TLC experiment. Thirty male Wistar rats in five groups were used in this experimental study and the rats were anesthetized with Ketamin (1 mg/kg), and standard ulcer (2 cm) was induced on the shaved dorsal by scatter.
Result : The results of this experiment showed that all extracts decreased the time of wound healing significantly in comparison with the controls groups. There was no symptom of colloid even scar
Conclusion : These extracts seem to accelerate the formation of the epidermis and causes wound healing. Total extract of Avena sativa has an important role in wound healing.
Source: Urmia Med J 2011: 22(5): 484 ISSN: 1027-3727
Fatemeh Hajari-Taheri , Mohammad-Hossein Yazdi, Mehdi Mahdavi, Mohammad-Ali Shokrgozar, Mansour Bayat, Mohsen Abolhassani,
Volume 23, Issue 7 (3-2013)
Abstract
Received: 12 Sep, 2012 Accepted: 15 Des, 2012
Abstract
Background & Aims : Candida albicans is one the widespread opportunistic fungal causing disease in human. Probiotics are useful bacteria with immunomodulatory effects on different spectrum of diseases. In this study the protective effect of Lactobacillus acidophilus and Lactobacillus Casei in reducing the Candida albicans infection in BALB/c mice were investigated.
Material & Methods : BALB/c mice were fed orally with 2.4 × 108 probiotics for a month and then were infected systemically with 2 × 10 6 Candida albicans via tail vein. Mice were again fed with probiotics for 2 weeks and then were sacrificed and the spleen cells were isolated and cultured with phytohemaglutinin. In the supernatant, the amount of IL-12, IL-4, TGF-β, and IFN-γ were measured using ELISA.
Results : Our results showed that mice using Lactobacillus Acidophilus had increased IL-4 and IL-12 level. However, the level of TGF-β was increased significantly in all infected mice. The results also show that with the applied dosage, the probiotics are not able to increase lymphocyte proliferation or mice survival.
Conclusion : These results showed that in mice model system with the schedule and dosage we used probiotics can be used as prophylactic but they from immunological point are not effective for treatment of Candida albicans systemic infection.
SOURCE: URMIA MED J 2012: 23(7): 828 ISSN: 1027-3727
Aghil Asa, Abdolhossein Taheri Kalani, Mahmoud Nikseresht,
Volume 30, Issue 11 (February 2020)
Abstract
Background & Aims: Neurotrophic and growth factors are known to have positive effects on neuronal proliferation. However, findings on the effects of exercise training on these factors following brain stroke are limited. Thus, the aim of the present study was to investigate the effect of endurance training on gene expression of nerve growth factor (NGF) and fibroblast growth factor (FGF) in the hippocampus of rats after brain stroke.
Materials & Methods: Twenty and one adult male Wistar rats (weighing 210-252 gr) were purchased and randomly divided into three groups: control, stroke, and stroke+ training groups. Stroke was induced by the occlusion of both common carotid arteries (CCA) for 45 minutes. The rats in the training group were run on a treadmill at speeds ranging from 18 to 30 meters per minute for 20 to 50 minutes per session, 5 days a week for 8 weeks. Forty eight hours after the last training session, rats were sacrificed and gene expression of NGF and FGF in the hippocampus were measured with the Real Time-PCR technique.
Results: In comparison to the control group, stroke led to a significant decrease in gene expression of NGF (p=0.0001) and FGF (p=0.0001). Also, after brain stroke, endurance training resulted in a significant increase in gene expression of NGF (p=0.001) and FGF (p=0.023) in the hippocampus of rats.
Conclusion: Based on the findings of this study, endurance training probably via up-regulation of neurotrophic and angiogenic factors could have therapeutic effects against ischemia-reperfusion induced injuries and decreased impairments induced by cerebral ischemia.
Solmaz Taheri, Farbod Vatan Parast, Bahareh Pourtaji, Bahareh Nazemi Salman,
Volume 31, Issue 7 (October 2020)
Abstract
Background & Aims: Body Mass Index (BMI) is a factor that affects the quality of panoramic images. This study aimed to evaluate the quality of panoramic digital images with Safe Beam Exposure (SBE) and manual dose adjustment among patients with different BMI levels.
Material & Methods: In this cross-sectional study, 200 patients, aged 20-60 years who were prescribed panoramic radiography in the course of their treatment were selected randomly as samples. 50% of the subjects were allocated to the manual dose adjustment group and 50% were distributed randomly to the SBE technology group. After grading quality of the images, scores were entered into the SPSS software.
Results: The mean age of participants was 37.96±11.96. 53.5% of participants were women and 46.5% were men. 87% of the samples fell in BMI of 18.5 ≤to ≥30. The overall quality of the images included noise (p=0.0003), contrast (p=0.0001), density (p=0.0002), and resolution (p=0.0003) and anatomical indicators included Laminadora (p= 0.0003), edge sharpness of teeth (p = 0.0002), mandibular canal walls (p = 0.0001), apex end of upper molar teeth (p= 0.0002), and DEJ limit (p= 0.0002). SBE technology in various categories of BMI was better than manual dose adjustment.
Conclusion: SBE technology could be used as a new technology to obtain images with higher quality and better anatomical resolution in various categories of BMI. As BMI decreases, the diagnostic quality of the different anatomical landmarks examined in the panoramic images increases.
Fatemeh Hatami, Morteza Taheri, Leila Yuzbashi, Khadija Irandoost, Maghsoud Nabilpour,
Volume 33, Issue 8 (November 2022)
Abstract
Background & Aims: Maintaining balance and preventing falls are important concerns for the elderly. Therefore, the aim of the current research was to study the interventional effect of eight weeks of Pilates exercises and soya consumption on knee and ankle joint proprioception of elderly women.
Materials & Methods: This semi-experimental and field-based research was done in a pre-test and post-test design. The statistical population was 45 elderly people over 60 years old from Zanjan city, Iran. Simple random and convenient sampling method was used in this research. For this, after announcing the call among the target community, 40 elderly people were selected based on Cochran's formula and divided into four groups: Pilates (10 people), soya (10 people), Pilates + soya (10 people), and control groups (10 people). To compare research groups, one-way analysis of variance and dependent t-test were used at the significance level of P<0.05.
Results: The Pilates group and the soya group were closer to the measuring criteria in knee flexion, dorsiflexion, and plantar flexion. Also, the Pilates + soya group showed significant improvement compared to all three groups (P<0.05).
Conclusion: Knee flexion, dorsiflexion, and ankle plantar flexion movements are among the movements that play central roles in maintaining body balance and preventing from falls and injuries. Therefore, performing pilates exercises with soybeans can improve physical fitness and maintain balance, and in general, ease daily activities.
Zahra Taheri, Zahra Tanha, Kourosh Amraee, Saba Hassanvand,
Volume 33, Issue 10 (January 2023)
Abstract
Background & Aim: People with diabetes are potentially threatened by other factors such as negative emotions, nervous system defects, and sensitivity to anxiety, which affects whether or not they are affected by diabetes-related wounds. The aim of the study was to investigate the effect of brain-behavioral system on diabetic female patients exposed to psychological vulnerability with the mediating role of anxiety sensitivity, positive and negative emotions and distress tolerance.
Materials & Methods: This research was applied in terms of purpose, and structural in terms of methods. The statistical population consisted of all women with diabetes in the specialized diabetes clinic of Karaj city, Iran in the first half of 2011, which 390 people were selected by purposive sampling method. To collect data, the questionnaires of Carver and White's behavioral brain systems, mental health questionnaire (SCL-25), Taylor and Cox's anxiety sensitivity, Watson, Clark and Telgen's positive and negative emotions, and Simmons and Gaher's distress tolerance were used. Regression equation tests were used to analyze the data. Data analysis was done using SPSS 18 and Amos 23 softwares.
Results: The results showed that the variables of behavioral brain system, anxiety sensitivity, positive and negative emotions and distress tolerance have direct and significant effects on psychological vulnerability. Also, the indirect path of the effect of the brain-behavioral system through the mediation of anxiety sensitivity, positive and negative emotions and distress tolerance on psychological vulnerability was confirmed. In general, the research model was confirmed and the research variables had the ability to predict 69% of the psychological vulnerability variable.
Conclusion: Considering the role of the behavioral brain system, anxiety sensitivity, positive and negative emotions, and distress tolerance on mental vulnerability, it is necessary for therapists to develop programs to reduce the mental damage of the behavioral brain system, anxiety sensitivity, positive and negative emotions, and distress tolerance in order to reduce psychological damage in these patients by changing these variables.
Zahra Tavakoli, Mahdieh Taheri, Mehrdad Roghani,
Volume 35, Issue 7 (October 2024)
Abstract
Background & Aims: Neuroinflammation has been reported as a key factor in the neuropathogenesis of cognitive disorders. Diosgenin, a steroidal sapogenin found in fenugreek, exhibits anti-inflammatory, anti-Alzheimer’s, and antioxidant effects. The aim of this study was to evaluate the effect of Diosgenin on cognitive deficits, cholinesterase activity, and astrogliosis following neuroinflammation induction in rats.
Materials & Methods: In this experimental study, 32 rats were randomly divided into four groups: Control, Control with Diosgenin treatment, Lipopolysaccharide (LPS), and LPS with Diosgenin treatment. Rats in the treatment groups received 40 mg/kg of Diosgenin daily for seven days orally. To induce neuroinflammation, lipopolysaccharide (1 mg/kg dissolved in normal saline) was injected intraperitoneally one hour before Diosgenin administration. Learning and memory were assessed using passive avoidance tasks. After preparing homogenized hippocampal tissue, molecular parameters were evaluated. Data were analyzed using one-way ANOVA followed by Tukey's post-hoc test, with p<0.05 considered statistically significant.
Results: Step-through latency was significantly increased in the LPS+Diosgenin group compared to the LPS group (P<0.01). Decreased acetylcholinesterase (AChE) activity (P<0.05) and increased catalase (CAT) activity (P<0.05), along with reduced GFAP (P<0.05) and malondialdehyde (MDA) levels (P<0.01), were observed in the LPS+Diosgenin group compared to the LPS group. A significant reduction in glutathione (GSH) levels (P<0.05) was noted in the LPS+Diosgenin group compared to the Control group. No significant differences were observed between the Diosgenin-treated Control group and the untreated Control group (P>0.05).
Conclusion: These findings suggest that Diosgenin is a memory-enhancing compound with antioxidant properties and has potential therapeutic applications in the treatment of various disorders, including neuroinflammation and leukemia, in the future.
