Iraj Salimi Kia, Shadi Sheikholeslami, Ali Ghaffarian Bahrmann, Mahsa Mohammadi, Mostafa Darabinejad, Hamidreza Mohammadi,
Volume 35, Issue 7 (October 2024)
Abstract
Background & Aims: Cholemic nephropathy is one of the important and serious complications associated with chronic liver damage and bile duct obstruction. Finding drug solutions to alleviate this complication or prevent its occurrence can be of clinical importance. Since luteolin is an antioxidant and one of the mechanisms of cholemic nephropathy is the induction of oxidative stress, this study was designed to investigate the protective effect of luteolin (LUT) on cholemic nephropathy in cholestatic rats.
Materials & Methods: In this experimental study, 50 male Wistar rats were used. Cholestasis was induced by common bile duct ligation (BDL). Rats were randomly divided into 5 groups of 10 as follows: a control group, a BDL group, and groups that received different doses of LUT (15, 5, and 30 mg/kg/day) daily by gavage for 14 days in addition to BDL. After the end of this intervention, the effect of cholestasis induction and the protective effects of LUT on serum, urine, and kidney tissue oxidative stress indices were examined.
Results: The present study showed that the levels of serum BUN and Cr, oxidative stress (MDA and ROS) indices in cholestatic rats were significantly increased compared to the control group (P < 0.001). Also, the activity of antioxidant enzymes (CAT, SOD, GPx) in cholestatic rats was significantly decreased compared to the control group (P < 0.001).
Conclusion: It seems that LUT can be a promising candidate for the prevention and treatment of renal damage caused by cholestasis by reducing oxidative stress and improving the activity of antioxidant enzymes.
