Volume 31, Issue 7 (October 2020)
Studies in Medical Sciences 2020, 31(7): 539-548 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
shirpoor M, tofighi A, Shirpoor A, chodari L, Pourjabali M. EFFECT OF MODERATE EXERCISES, CURCUMIN AND THEIR COMBINATION ON LEVELS OF LEPTIN AND HEPATIC ENZYMES IN ELDERLY MALE RATS. Studies in Medical Sciences 2020; 31 (7) :539-548
URL: http://umj.umsu.ac.ir/article-1-5269-en.html
URL: http://umj.umsu.ac.ir/article-1-5269-en.html
Department of Exercise Physiology and corrective movements, Faculty of Sport Sciences, Urmia University, Urmia, Iran (Corresponding Author) , a.tofighi@urmia.ac.ir
Abstract: (3662 Views)
Background & Aims: Nonalcoholic fatty liver disease is a common liver disease in the world and most studies show that there is a relationship between aging and the prevalence of this disease.
Regarding the side effect of chemical drugs, it is better to control and treat this disease by changing the lifestyle and diet. In this study, we investigated the effects of 8 weeks of moderate-intensity aerobic exercise training and administration of curcumin supplementation alone and together on levels of leptin and hepatic enzymes in elderly male rats.
Materials & Methods: Thirty-two aged and eight young rats were divided into five groups: young control, aged control, aged-curcumin, aged-exercise, and aged- curcumin-exercise co-treatment.
Results: After eight weeks of treatment, the results revealed a significant decrease in leptin after curcumin administration in compared to aged control but there was no significant changes in amount of hepatic enzymes. Moreover, 8 weeks of exercise training did not have a significant effect on the amounts of leptin and hepatic enzymes compared to aged control group.
Also 8 weeks of treatment with curcumin and exercise together decreased the levels of leptin and hepatic enzymes significantly.
Conclusion: The results of this study showed that consuming curcumin and moderate exercise training has positive effects on the treatment of nonalcoholic fatty liver disease.
Regarding the side effect of chemical drugs, it is better to control and treat this disease by changing the lifestyle and diet. In this study, we investigated the effects of 8 weeks of moderate-intensity aerobic exercise training and administration of curcumin supplementation alone and together on levels of leptin and hepatic enzymes in elderly male rats.
Materials & Methods: Thirty-two aged and eight young rats were divided into five groups: young control, aged control, aged-curcumin, aged-exercise, and aged- curcumin-exercise co-treatment.
Results: After eight weeks of treatment, the results revealed a significant decrease in leptin after curcumin administration in compared to aged control but there was no significant changes in amount of hepatic enzymes. Moreover, 8 weeks of exercise training did not have a significant effect on the amounts of leptin and hepatic enzymes compared to aged control group.
Also 8 weeks of treatment with curcumin and exercise together decreased the levels of leptin and hepatic enzymes significantly.
Conclusion: The results of this study showed that consuming curcumin and moderate exercise training has positive effects on the treatment of nonalcoholic fatty liver disease.
Type of Study: Research |
Subject:
Exercise physiology
References
1. Kim H, Kisseleva T, Brenner DA. Aging and liver disease. Curr Opin Gastroenterol 2015; 31(3): 184-91. [DOI:10.1097/MOG.0000000000000176] [PMID] [PMCID]
2. Gong Z, Tas E, Yakar S, Muzumdar R. Hepatic lipid metabolism and non-alcoholic fatty liver disease in aging. Mol Cell Endocrinol 2017; 455: 115-30. [DOI:10.1016/j.mce.2016.12.022] [PMID]
3. Angrish MM, Kaiser JP, McQueen CA, Chorley BN. Tipping the Balance: Hepatotoxicity and the 4Apical Key Events of Hepatic Steatosis. Toxicol Sci 2016; 150(2): 261-8. [DOI:10.1093/toxsci/kfw018] [PMID]
4. Orman ES, Odena G, Bataller R. Alcoholic liver disease: pathogenesis, management, and noveltargets for therapy. J Gastroenterol Hepatol 2013; 28: 77-84. [DOI:10.1111/jgh.12030] [PMID] [PMCID]
5. Reddy JK, Sambasiva Rao M. Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation. Am J Physiol Gastrointest Liver Physiol 2006; 290(5): G852-8. [DOI:10.1152/ajpgi.00521.2005] [PMID]
6. Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002; 346(16): 1221-31. [DOI:10.1056/NEJMra011775] [PMID]
7. Chang Y, Ryu S, Sung E, Jang Y. Higher concentrations of alanine aminotransferase within the reference interval predict nonalcoholic fatty liver disease. Clin Chem 2007; 53(4):686-92. [DOI:10.1373/clinchem.2006.081257] [PMID]
8. Adolph TE, Grander C, Grabherr F, Tilg H. Adipokines and Non-Alcoholic Fatty Liver Disease: Multiple Interactions. Int J Mol Sci 2017; 18(8): 1649. [DOI:10.3390/ijms18081649] [PMID] [PMCID]
9. Polyzos SA, Kountouras J, Mantzoros CS. Leptin in nonalcoholic fatty liver disease: a narrative review. Metabolism 2015; 64(1): 60-78. [DOI:10.1016/j.metabol.2014.10.012] [PMID]
10. Wang Y, Zhou M, Lam KS, Xu A. Protective roles of adiponectin in obesity-related fatty liver diseases: mechanisms and therapeutic implications. Arq Bras Endocrinol Metabol 2009; 53(2): 201-12. [DOI:10.1590/S0004-27302009000200012] [PMID]
11. Lee Y, Wang MY, Kakuma T, Wang ZW, Babcock E, McCorkle K, et al. Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia. J Biol Chem 2001; 276(8): 5629-35. [DOI:10.1074/jbc.M008553200] [PMID]
12. Whitsett M, VanWagner LB. Physical activity as a treatment of non-alcoholic fatty liver disease: A systematic review. World J Hepatol 2015; 7(16): 2041-52. [DOI:10.4254/wjh.v7.i16.2041] [PMID] [PMCID]
13. Shamsoddini A, Sobhani V, Chehreh ME, Alavian SM, Zaree A. Effect of Aerobic and Resistance Exercise Training on Liver Enzymes and Hepatic Fat in Iranian Men With Nonalcoholic Fatty Liver Disease. Hepat Mon 2015; 15(10):e31434. [DOI:10.5812/hepatmon.31434] [PMID] [PMCID]
14. Kawanishi N, Yano H, Mizokami T, Takahashi M, Oyanagi E, Suzuki K. Exercise training attenuates hepatic inflammation, fibrosis and macrophage infiltration during diet induced-obesity in mice. Brain Behav Immun 2012; 26(6): 931-41. [DOI:10.1016/j.bbi.2012.04.006] [PMID]
15. Barzegarzadeh-Zarandi H, Dabidy-Roshan V. Changes in some liver enzymes and blood lipid levelfollowing interval and continuous regular aerobic training in old rats. J Shahrekord Univ Med Sci 2012; 14(5): 13-23. [Google Scholar]
16. Stickel F, Schuppan D. Herbal medicine in the treatment of liver diseases. Dig Liver Dis 2007; 39(4): 293-304. [DOI:10.1016/j.dld.2006.11.004] [PMID]
17. Schuppan D, Jia JD, Brinkhaus B, Hahn EG. Herbal products for liver diseases: a therapeutic challenge for the new millennium. Hepatology 1999; 30(4): 1099-104. [DOI:10.1002/hep.510300437] [PMID]
18. Kunchandy E, Rao MN. Oxygen radical scavenging activity of curcumin. Int J Pharm 1990; 58(3): 237-40. [DOI:10.1016/0378-5173(90)90201-E]
19. Zhou H, S Beevers C, Huang S. The targets of curcumin. Curr Drug Targets 2011; 12(3): 332-47. [DOI:10.2174/138945011794815356] [PMID] [PMCID]
20. Ahren BO, Mansson S, Gingerich RL, Havel PJ. Regulation of plasma leptin in mice: influence of age, high-fat diet, and fasting. Am J Physiol 1997; 273(1):R113-20. [DOI:10.1152/ajpregu.1997.273.1.R113] [PMID]
21. Wang ZW, Pan WT, Lee Y, Kakuma T, Zhou YT, Unger RH. The role of leptin resistance in the lipid abnormalities of aging. FASEB J 2001; 15(1): 108-14. [DOI:10.1096/fj.00-0310com] [PMID]
22. Kraemer RR, Kraemer GR, Acevedo EO, Hebert EP, Temple E, Bates M, et al. Effects of aerobic exercise on serum leptin levels in obese women. Eur J Appl Physiol 1999; 80: 154-8. [DOI:10.1007/s004210050572] [PMID]
23. Houmard JA, Cox JH, MacLean PS, Barakat HA. Effect of short-term exercise training on leptin and insulin action. Metabolism 2000; 49(7): 858-61. [DOI:10.1053/meta.2000.6751] [PMID]
24. Hayase H, Nomura S, Abe T, Izawa T. Relation between fat distributions andseveral plasma adipocytokines alter exercise training in premenopausal and postmenopausal women. J Physiol Anthropol 2002; 21(2): 105-13. [DOI:10.2114/jpa.21.105] [PMID]
25. Miyatake N, Takahashi K, Wada J, Nishikawa H, Morishita A, Suzuki H, et al. Changes in serum leptin concentrations in overweight Japanese men after exercise. Diabetes Obes Metab 2004; 6(5): 332-7. [DOI:10.1111/j.1462-8902.2004.00351.x] [PMID]
26. Song WY, Choi JH. Korean Curcuma longa L. induces lipolysis and regulates leptin in adipocyte cells and rats. Nutr Res Pract 2016; 10(5): 487-93. [DOI:10.4162/nrp.2016.10.5.487] [PMID] [PMCID]
27. Navekar R, Rafraf M, Ghaffari A, Asghari-Jafarabadi M, Khoshbaten M. Turmeric Supplementation Improves Serum Glucose Indices and Leptin Levels in Patients with Nonalcoholic Fatty Liver Diseases. J Am Coll Nutr 2017; 36(4): 261-7. [DOI:10.1080/07315724.2016.1267597] [PMID]
28. Moradi Kelardeh B, Azarbayjani M A, Peeri M, Matin Homaee H. Effect of curcumin supplementation and resistance TRAinING in patients with nonalcoholic fatty liver disease. Journal of Medicinal Plants 2016; 15 (60):161-172. [Google Scholar]
29. 29 Panahi Y, Kianpour P, Mohtashami R, Jafari R, Simental-Mendía LE, Sahebkar A. Efficacy and safety of phytosomal curcumin in non-alcoholic fatty liver disease: a randomized controlled trial. Drug Res 2017; 67: 244-51. [DOI:10.1055/s-0043-100019] [PMID]
30. Kim HY, Park EJ, Joe EH, Jou I. Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microglia. J Immunol 2003; 171(11): 6072-9. [DOI:10.4049/jimmunol.171.11.6072] [PMID]
31. Kumar A, Dhawan S, Hardegen NJ, Aggarwal BB. Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappaB activation. Biochem Pharmacol 1998; 55(6): 775-83. [DOI:10.1016/S0006-2952(97)00557-1]
32. Abe Y, Hashimoto SH, Horie T. Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages. Pharmacol Res 1999; 39(1): 41-7. [DOI:10.1006/phrs.1998.0404] [PMID]
33. Suzuki A, Abdelmalek MF. Nonalcoholic fattyliver disease in women. Womens Health (Lond) 2009; 5(2): 191 - 203. [DOI:10.2217/17455057.5.2.191] [PMID]
34. Frith J, Jones D, Newton JL. Chronic liver disease in an ageing population. Age Ageing 2009; 38(1): 11-8. [DOI:10.1093/ageing/afn242] [PMID]
35. Mikami T, Sumida S, Ishibashi Y, Ohta S. Endurance exercise training inhibits activity of plasma GOT and liver caspase-3 of mice (correction of rats) exposed to stress by induction of heat shock protein 70. J Appl Physiol 2004;96(5):1776-81. [DOI:10.1152/japplphysiol.00795.2002] [PMID]
36. Haus JM, Solomon TP, Kelly KR, Fealy CE, Kullman EL, Scelsi AR,, et al. Improved hepatic lipid composition following short-term exercise in nonalcoholic Fatty liver disease. J Clin Endocrinol Metab 2013; 98(7): 1181-8. [DOI:10.1210/jc.2013-1229] [PMID] [PMCID]
37. Hallsworth K, Avery L, Trenell MI. Targeting lifestyle behavior change in adults with NAFLD during a 20-min consultation: summary of the dietary and exercise literature. Curr Gastroenterol Rep 2016; 18(3): 11.1-7. [DOI:10.1007/s11894-016-0485-1] [PMID] [PMCID]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
