Volume 28, Issue 8 (Monthly_Nov 2017)                   Studies in Medical Sciences 2017, 28(8): 8-16 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Gorban nejad M, Gorbanian M T. Effects of male phermoneses on neuronal morphology in the dentate gyrus of hippocampus of female Mice. Studies in Medical Sciences 2017; 28 (8) :8-16
URL: http://umj.umsu.ac.ir/article-1-4044-en.html
Faculty of Biology and Life Sciences, Damghan University, Damghan, Iran , ghorbanian@du.ac.ir
Abstract:   (20241 Views)
Background & Aims: Neurogenesis in the adult mammal brain occurs throughout life. Adult neurogenesis has been clearly demonstrated in the sub granular zone (SGZ) of the dentate gyrus (DG) in the hippocampus. Pheromones that plays an essential role in the development of the central nervous system. The male pheromones are involved in regulating neurogenesis in both the olfactory bulb and hippocampus, which may be important for female reproductive success. The golgi silver impregnation method is a powerful method still routinely used for studying neuronal morphology. The aim of the present study was to investigate the effects of pheromones on the neuronal morphology in the mice hippocampus.
Materials and Methods: Thirty adult NMRI mice 6-8 weeks were used in this study. Adult female animals were divided into four groups. These intact and bilaterally ovariectomized mice and males were placed with and without wire mesh in cage. The animals were sacrificed by cervical dislocation and brain was sectioned (50 μm) and stained with golgi method and observed by microscope.
Results: Neuronal arborization in pheromones group has different with and without pheromones groups. The morphology features of the dentate gyrus neurons of the hippocampus were varied in the exposure to the pheromones as compared to other group.
Conclusion: This study report that the pheromones of males stimulate neurogenesis and neuronal morphology in the hippocampus of female mice.
Full-Text [PDF 460 kb]   (979 Downloads)    
Type of Study: Research | Subject: بافت شناسی

1. Gage FH. Mammalian neural stem cells. Science 2000 25;287(5457): 1433-8. [PubMed]
2. Alvarez-Buylla A, García-Verdugo JM, Tramontin AD. A unified hypothesis on the lineage of neural stem cells: Nat Rev Neurosci 2001;2(4): 287-93. [PubMed]
3. Lie DC, Song H, Colamarino SA, Ming GL, Gage FH. Neurogenesis in the adult brain: new strategies for central nervous system diseases. Annu Rev Pharmacol Toxicol 2004; 44: 399-421. [PubMed]
4. Pawluski JL, Brummelte S, Barha CK, Crozier TM, Galea LA. Effects of steroid hormones on neurogenesis in the hippocampus of the adult female rodent during the estrous cycle, pregnancy, lactation and aging. Front Neuroendocrinol 2009;30(3): 343-57. [PubMed]
5. Van Praag H, Schinder AF, Christie BR, Toni N, Palmer TD, Gage FH. Functional neurogenesis in the adult hippocampus. Nature 2002;415(6875): 1030-4. [Google Scholar]
6. Bonfanti L, Ponti G. Adult mammalian neurogenesis and the New Zealand white rabbit. Vet J 2008;175(3): 310-31. [PubMed]
7. Tanapat P, Hastings NB, Reeves AJ, Gould E. Estrogen stimulates a transient increase in the number of new neurons in the dentate gyrus of the adult female rat. J Neurosci 1999;19(14): 5792-801. [PubMed]
8. Dulac, C. and Torello, A.T. Molecular detection of pheromone signals in mammals: from genes to behaviour. Nat Rev Neurosci 2003;4(7): 551-62. [PubMed]
9. Cardwell J, Stacey N, Lang S, Tan E, McAdam D. Androgen increases olfactory receptor response to a vertebrate sex pheromone. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 1995; 176, 55-61. [Google Scholar]
10. Henningsson S, Hovey D1, Vass K, Walum H, Sandnabba K, Santtila P, Jern P, Westberg L. A missense polymorphism in the putative pheromone receptor gene VN1R1 is associated with sociosexual behavior. Transl Psychiatry 2017 25;7(4): e1102. [PubMed]
11. Lee WS, Smith MS, Hoffman GE. Luteinizing hormone-releasing hormone neurons express Fos protein during the proestrous surge of luteinizing hormone. Proc Natl Acad Sci U S A 1990;87(13): 5163-7. [PubMed]
12. Cohen-Tannoudji J, Lavenet C, Locatelli A, Tillet Y, Signoret JP. Non-involvement of the accessory olfactory system in the LH response of anoestrous ewes to male odour. J Reprod Fertil 1989;86(1): 135-44. [PubMed]
13. Kohl JV, Atzmueller M, Fink B, Grammer K. Human pheromones: integrating neuroendocrinology and ethology. Neuro Endocrinol Lett 2001;22(5): 309-21. [PubMed]
14. Galea LA. Gonadal hormone modulation of neurogenesis in the dentate gyrus of adult male and female rodents. Brain Res Rev 2008;57(2): 332-41. [PubMed]
15. Musso AE, Gries R, Zhai H, Takács S, Gries G. Effect of Male House Mouse Pheromone Components on Behavioral Responses of Mice in Laboratory and Field Experiments. J Chem Ecol 2017;43(3): 215-24. [PubMed]
16. Takács S, Gries R, Gries G. Sex Hormones Function as Sex Attractant Pheromones in House Mice and Brown Rats. Chembiochem 2017;18(14):1391–5. [PubMed]
17. Takács S, Gries R, Zhai H, Gries G. The Sex Attractant Pheromone of Male Brown Rats: Identification and Field Experiment. Angew Chem Int Ed Engl 2016;55(20): 6062-6. [PubMed]
18. Mak GK, Enwere EK, Gregg C, Pakarainen T, Poutanen M, Huhtaniemi I, Weiss S. Male pheromone–stimulated neurogenesis in the adult female brain: possible role in mating behavior. Nat Neurosci 2007;10(8): 1003-11. [PubMed]
19. Gheusi G, Ortega-Perez I, Murray K, Lledo PM. A niche for adult neurogenesis in social behavior. Behav Brain Res 2009; 25;200(2): 315-22. [PubMed]
20. Singh M, Su C. Progesterone and neuroprotection. Horm Behav 2013; 63: 284-90. [PubMed]
21. Dellovade TL, Hunter E, Rissman EF. Interactions with males promote rapid changes in gonadotropin-releasing hormone immunoreactive cells. Neuroendocrinology 1995;62(4): 385-95. [PubMed]

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2023 CC BY-NC 4.0 | Studies in Medical Sciences

Designed & Developed by : Yektaweb