Volume 27, Issue 12 (Monthly-Mar 2017)                   Studies in Medical Sciences 2017, 27(12): 1032-1040 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Tolouei Azar J, Ravasi A, Soori R, Akbarnejad A, Hemati Nafar M. The Effect of 8 Weeks Aerobic Training on Angiogenesis (VEGF) and Angiostatic (ES) Factors In Sedentary Women. Studies in Medical Sciences 2017; 27 (12) :1032-1040
URL: http://umj.umsu.ac.ir/article-1-3608-en.html
Urmia University , j.tolouei@gmail.com
Abstract:   (8011 Views)

Background & Aims: It is more important to know which of physical activities could be the most effective way to cause angiogenesis. In this regards, we have investigated an 8-week aerobic training on vascular endothelial growth factor (VEGF) and Endostatin (ES) in sedentary women.

Materials & Methods: 20 volunteer inactive women were chosen and were randomly divided in 2 groups of aerobic and control. Aerobic training programme consisted of 3 days per week for 8 weeks, each consists of 30 minutes with intensity of 65-70% of maximum heart rate was performed.. Before and after training, we have tested aerobic training and control group after an overnight fast. Blood Samples were used to conduct Enzyme-linked immunosorbent assay (ELISA). Independent and Dependent T-Test t were performed to see the significance level of (P<0.05.

Results: Statistical analysis revealed that aerobic training increased VEGF and decreased ES to a significant level. Consequently, the results of Independent T Test revealed that there is an obvious difference (P<0.05), between the amount of VEGF and ES in control and intervention group.

Conclusion:The results show that the equilibrium between angiogenesis and angiostatic agents. As a result, aerobic training is shifted toward angiogenesis factors. This result helps us to understand the process of angiogenesis consistence with aerobic training activities.

Full-Text [PDF 317 kb]   (3810 Downloads)    
Type of Study: Clinical trials | Subject: Exercise physiology

1. Dufaux B, Assmann G, Hollmann W. Plasma lipoproteins and physical activity: a review. Int J Sports Med 1982;3(3): 123-36. [PubMed]
2. Helmrich SP, Ragland DR, Leung RW, Paffenbarger Jr RS. Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N Engl J Med 1991;325(3): 147-52. [PubMed]
3. Fagard R. Exercise is good for your blood pressure: effects of endurance training and resistance training. Clin Exp Pharmacol Physiol 2006;33(9): 853-6. [PubMed]
4. Tang K, Xia FC, Wagner PD, Breen EC. Exercise-induced VEGF transcriptional activation in brain, lung and skeletal muscle. Respir Physiol Neurobiol 2010;170(1): 16-22. [PubMed]
5. Suhr F, Brixius K, de Marées M, Bölck B, Kleinöder H, Achtzehn S, et al. Effects of short-term vibration and hypoxia during high-intensity cycling exercise on circulating levels of angiogenic regulators in humans. J Appl Physiol (1985) 2007;103(2): 474-83. [PubMed]
6. Brown M, Hudlicka O. Modulation of physiological angiogenesis in skeletal muscle by mechanical forces: involvement of VEGF and metalloproteinases. Angiogenesis 2003;6(1): 1-14. [PubMed]
7. Richardson R, Wagner H, Mudaliar S, Saucedo E, Henry R, Wagner P. Exercise adaptation attenuates VEGF gene expression in human skeletal muscle. Am J Physiol Heart Circ Physiol 2000;279(2): H772-H8. [PubMed]
8. Felmeden D, Blann A, Lip G. Angiogenesis: basic pathophysiology and implications for disease. Eur Heart J 2003;24(7): 586-603. [PubMed]
9. Huber-Abel FA, Gerber M, Hoppeler H, Baum O. Exercise-induced angiogenesis correlates with the up-regulated expression of neuronal nitric oxide synthase (nNOS) in human skeletal muscle. European J Appl Physiol (1985) 2012;112(1): 155-62. [PubMed]
10. Gavin T, Drew J, Kubik C, Pofahl W, Hickner R. Acute resistance exercise increases skeletal muscle angiogenic growth factor expression. Acta Physiol 2007;191(2): 139-46. [PubMed]
11. Zachary I, Gliki G. Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. Cardiovasc Res 2001;49(3): 568-81. [PubMed]
12. Ranjit Pm, Anuradha C, Vishnupriya S, Girijasankar G, Girish K, Chowdary Y. Endogenous Angiogenesis Inhibitor Endostatin: An Overview. Liver 2012;13: 14. [Google Scholar]
13. Bloor CM. Angiogenesis during exercise and training. Angiogenesis 2005;8(3): 263-71. [Google Scholar]
14. Ravasi AA, Yadegari M, Choobineh S. Comparison of two types of physical activity on response serum VEGF-A, non-athletic men. J Sport Biosciences 2014;6(1): 41-56. [Google Scholar]
15. Nourshahi M. BA, Bigdeli M. R.,Ghasemi B. M.. The Effect of Six Weeks of Resistance Training on Tumor Tissue VEGF and Endostatin in Mice with Breast Cancer. J Sport Biosciences 2013;5(2): 27-46. [Google Scholar]
16. Rojas Vega S, Knicker A, Hollmann W, Bloch W, Strüder HK. Effect of resistance exercise on serum levels of growth factors in humans. Horm Metab Res 2010;42(13):982–6. [Google Scholar]
17. Nourshahi Maryam., Ghasemi B. M., Ayyub B., Zoheyr H., F. S. Effect of Six Weeks Continuous Aerobic Training on Tumoral Tissue Expression of Vascular Endothelial Growth Factor (VEGF) and Endostatin in Mice with Breast Cancer. J Tabriz Univ Med Sci 2012;34(6): 82-9. [Google Scholar]
18. Shekarchizadeh P, Khazaei M, Gharakhanlou R, Karimian J. The Effects of Resistance Training on Plasma Angiogenic Factors in Normal Rats. J Isfahan Med School 2012;30(176): 1-9. [Google Scholar]
19. Ranjbar K., Nourshahi M., Hedayati M., H. TC. Effect of Gender and Physical Activity on Serum Vascular Endothelial Growth Factor at Rest and Response to Submaximal Exercise. Iran J Endocrinol Metab 2011; 13(3): 294-300. [Google Scholar]
20. Gustafsson T, Rundqvist H, Norrbom J, Rullman E, Jansson E, Sundberg CJ. The influence of physical training on the angiopoietin and VEGF-A systems in human skeletal muscle. J Appl Physiol (1985) 2007;103(3): 1012-20. [PubMed]
21. Gustafsson T, Puntschart A, Kaijser L, Jansson E, Sundberg CJ. Exercise-induced expression of angiogenesis-related transcription and growth factors in human skeletal muscle. Am J Physiol Heart Circ Physiol 1999;276(2): H679-H85. [PubMed]
22. Gavin TP, Robinson CB, Yeager RC, England JA, Nifong LW, Hickner RC. Angiogenic growth factor response to acute systemic exercise in human skeletal muscle. J Appl Physiol (1985) 2004;96(1): 19-24. [PubMed]
23. Hoier B, Nordsborg N, Andersen S, Jensen L, Nybo L, Bangsbo J, et al. Pro‐and anti‐angiogenic factors in human skeletal muscle in response to acute exercise and training. J Physiol 2012;590(3): 595-606. [PubMed]
24. Brixius K, Schoenberger S, Ladage D, Knigge H, Falkowski G, Hellmich M, et al. Long-term endurance exercise decreases antiangiogenic endostatin signalling in overweight men aged 50–60 years. Br J Sports Med 2008;42(2): 126-9. [PubMed]
25. Hudlicka O, Brown M, Egginton S. Angiogenesis in skeletal and cardiac muscle. Physiol Rev 1992;72(2): 369-417. [Google Scholar]
26. Sundberg C, Kaijser L. Effects of graded restriction of perfusion on circulation and metabolism in the working leg; quantification of a human ischaemia‐model. Acta Physiol Scand 1992;146(1): 1-9. [PubMed]
27. Hudlicka O, Brown MD. Adaptation of skeletal muscle microvasculature to increased or decreased blood flow: role of shear stress, nitric oxide and vascular endothelial growth factor. J Vasc Res 2008;46(5): 504-12. [Google Scholar]
28. Gavin TP. Basal and exercise-induced regulation of skeletal muscle capillarization. Exerc Sport Sci Rev 2009;37(2): 86-92. [PubMed]
29. Yang HT, Prior BM, Lloyd PG, Taylor JC, Li Z, Laughlin MH, et al. Training-induced vascular adaptations to ischemic muscle. J Physiol Pharmacol 2008;59 Suppl 7:57–70. [PubMed]
30. Ohno H, Shirato K, Sakurai T, Ogasawara J, Sumitani Y, Sato S, et al. Effect of exercise on HIF-1 and VEGF signaling. J Physical Fitness Sport Med 2012;1(1): 5-16. [Google Scholar]
31. Wickström SA, Alitalo K, Keski-Oja J. Endostatin associates with integrin α5β1 and caveolin-1, and activates Src via a tyrosyl phosphatase-dependent pathway in human endothelial cells. Cancer Res 2002;62(19): 5580-9. [PubMed]
32. Hanai J-i, Dhanabal M, Karumanchi SA, Albanese C, Waterman M, Chan B, et al. Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1. J Biological Chemistry 2002;277(19): 16464-9. [PubMed]
33. Urbich C, Reissner A, Chavakis E, Dernbach E, Haendeler J, Fleming I, et al. Dephosphorylation of endothelial nitric oxide synthase contributes to the anti-angiogenic effects of endostatin. FASEB J 2002;16(7):706–8. [PubMed]
34. Rullman E, Rundqvist H, Wågsäter D, Fischer H, Eriksson P, Sundberg CJ, et al. A single bout of exercise activates matrix metalloproteinase in human skeletal muscle. J Appl Physiol (1985) 2007;102(6): 2346-51. [PubMed]
35. Bernfield M, Götte M, Park PW, Reizes O, Fitzgerald ML, Lincecum J, et al. Functions of cell surface heparan sulfate proteoglycans. Annu Rev Biochem 1999;68(1): 729-77. [Google Scholar]
36. Ferreras M, Felbor U, Lenhard T, Olsen BR, Delaissé J-M. Generation and degradation of human endostatin proteins by various proteinases. FEBS letters 2000;486(3): 247-51. [Google Scholar]
37. Noris M, Morigi M, Donadelli R, Aiello S, Foppolo M, Todeschini M, et al. Nitric oxide synthesis by cultured endothelial cells is modulated by flow conditions. Circ Res 1995;76(4): 536-43. [PubMed]

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Studies in Medical Sciences

Designed & Developed by : Yektaweb