دوره 35، شماره 7 - ( مهر 1403 )
جلد 35 شماره 7 صفحات 620-604 |
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Tavakoli Z, Taheri M, Roghani M. THE EFFECT OF DIOSGENIN ON COGNITIVE DEFICITS AND OXIDATIVE STRESS INDUCED BY LIPOPOLYSACCHARIDE IN RATS. Studies in Medical Sciences 2024; 35 (7) :604-620
URL: http://umj.umsu.ac.ir/article-1-6326-fa.html
URL: http://umj.umsu.ac.ir/article-1-6326-fa.html
توکلی زهرا، طاهری مهدیه، روغنی مهرداد. اثر دیوسجنین بر اختلال شناختی و استرس اکسیداتیو القاشده با لیپوپلی ساکارید در موش صحرایی. مجله مطالعات علوم پزشکی. 1403; 35 (7) :604-620
استاد، مرکز تحقیقات نوروفیزیولوژی، دانشگاه شاهد، تهران، ایران (نویسنده مسئول) ، mroghani@shahed.ac.ir
چکیده: (770 مشاهده)
مواد و روش کار: در این مطالعه تجربی 32 موش صحرایی نر نژاد ویستار بر اساس جدول تصادفی اعداد به 4 گروه کنترل، کنترل تحت تیمار با دیوسجنین، لیپوپلی‌ساکارید، و گروه لیپوپلی‌ساکارید تحت تیمار با دیوسجنین تقسیم شدند. موش‌های تحت تیمار میزان 40 میلی‌گرم بر کیلوگرم دیوسجنین را به مدت هفت روز و روزانه و به فرم خوراکی دریافت کردند. برای القا التهاب عصبی، لیپوپلی‌ساکارید حل‌شده در نرمال سالین به میزان 1 میلی‌گرم بر کیلوگرم به فرم داخل صفاقی در اولین روز و یک ساعت قبل از تزریق دیوسجنین تزریق شد. از تست شاتل باکس برای بررسی حافظه و یادگیری استفاده شد. با استفاده از هموژنه بافتی هیپوکامپ، سنجش پارامترهای مولکولی انجام شد. آنالیز آماری داده‌ها با آزمون آنووای یک‌طرفه و تست تعقیبی توکی و سطح معنی‌داری 05/0p˂ انجام شد.
یافته‌ها: میزان تأخیر هنگام عبور در گروه لیپوپلی‌ساکارید دریافت‌کننده دیوسجنین افزایش معنی‌داری در مقایسه با گروه لیپوپلی‌ساکارید داشت (P<0.01). گروه لیپوپلی‌ساکارید دریافت‌کننده دیوسجنین در مقایسه با گروه لیپوپلی‌ساکارید فعالیت کولین‌استراز کاهش (P<0.05) و کاتالاز افزایش (P<0.05) معنی‌داری پیدا کرد و کاهش میزان GFAP (P<0.05) و MDA (P<0.01) نشان داد. میزان GSH در گروه دریافت‌کننده دیوسجنین در مقایسه با گروه کنترل کاهش معنی‌دار (P<0.05) نشان داد. گروه کنترل تحت تیمار با دیوسجنین در فاکتورهای موردبررسی با گروه کنترل تفاوت معنادار نداشت (P>0.05).
بحث و نتیجه‌گیری: داده‌های ما نشان می‌دهد که دیوسجنین با خواص آنتی‌اکسیدانی داروی تقویت‌کننده حافظه است و می‌تواند برای درمان انواع مختلف اختلالات مانند لوسمی و التهاب در آینده مورداستفاده قرار گیرد.
نوع مطالعه: پژوهشي(توصیفی- تحلیلی) |
موضوع مقاله:
فیزیولوژی
فهرست منابع
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